ATE398451T1 - Festes, teilchenförmiges tadalafil mit bimodaler teilchengrössenverteilung - Google Patents

Festes, teilchenförmiges tadalafil mit bimodaler teilchengrössenverteilung

Info

Publication number
ATE398451T1
ATE398451T1 AT06802484T AT06802484T ATE398451T1 AT E398451 T1 ATE398451 T1 AT E398451T1 AT 06802484 T AT06802484 T AT 06802484T AT 06802484 T AT06802484 T AT 06802484T AT E398451 T1 ATE398451 T1 AT E398451T1
Authority
AT
Austria
Prior art keywords
size distribution
tadalafil
solid
particle
shaped
Prior art date
Application number
AT06802484T
Other languages
English (en)
Inventor
Judith Aronhime
Guy Samburski
Yhoshoa Ovadya
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of ATE398451T1 publication Critical patent/ATE398451T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Packages (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Secondary Cells (AREA)
AT06802484T 2005-08-29 2006-08-29 Festes, teilchenförmiges tadalafil mit bimodaler teilchengrössenverteilung ATE398451T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US71258905P 2005-08-29 2005-08-29

Publications (1)

Publication Number Publication Date
ATE398451T1 true ATE398451T1 (de) 2008-07-15

Family

ID=37809413

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06802484T ATE398451T1 (de) 2005-08-29 2006-08-29 Festes, teilchenförmiges tadalafil mit bimodaler teilchengrössenverteilung

Country Status (13)

Country Link
US (1) US20070098804A1 (de)
EP (1) EP1843770B1 (de)
JP (1) JP2008518041A (de)
KR (1) KR20070067173A (de)
AT (1) ATE398451T1 (de)
BR (1) BRPI0606122A2 (de)
CA (1) CA2610668A1 (de)
DE (1) DE602006001510D1 (de)
ES (1) ES2308750T3 (de)
IL (1) IL185938A0 (de)
PL (1) PL1843770T3 (de)
PT (1) PT1843770E (de)
WO (1) WO2007027612A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638138B2 (en) 2003-02-21 2009-12-29 Translational Research, Ltd. Compositions for nasal administration of pharmaceuticals
AU2003220808B2 (en) 2003-03-27 2008-08-21 Bioactis Limited Powder medicine applicator for nasal cavity
CN101668544B (zh) 2006-12-26 2013-04-24 株式会社新日本科学 经鼻投用制剂
GB0712316D0 (en) * 2007-06-26 2007-08-01 Entripneur Ltd A novel powder and its method of manufacture
EP2238979A1 (de) 2009-04-06 2010-10-13 LEK Pharmaceuticals d.d. Auf einem festen Träger adsorbierter pharmazeutischer Wirkstoff
EP2429495A4 (de) * 2009-05-15 2014-01-22 Shin Nippon Biomedical Lab Ltd Intranasale pharmazeutische zusammensetzung mit verbesserter pharmakokinetik
WO2011013003A2 (en) * 2009-07-31 2011-02-03 Shin Nippon Biomedical Laboratories, Ltd. Intranasal granisetron and nasal applicator
WO2011030351A2 (en) 2009-09-03 2011-03-17 Rubicon Research Private Limited Taste - masked pharmaceutical compositions
WO2013109223A1 (en) * 2012-01-18 2013-07-25 Mahmut Bilgic Particulate formulations of tadalafil in effervescent form
WO2014092661A1 (en) * 2012-01-18 2014-06-19 Mahmut Bilgic Particulate formulations of tadalafil in effervescent form
US20160136282A1 (en) 2014-11-18 2016-05-19 Genovate Biotechnology Co., Ltd. Novel formulation of cilostazol, a quinolinone-derivative used for alleviating the symptom of intermittent claudication in patients with peripheral vascular disease
MX2016002581A (es) * 2016-02-26 2017-08-25 Apotex Tech Inc Formulaciones farmaceuticas novedosas que comprenden un inhibidor de pde5.
CA3018191C (en) * 2016-03-31 2022-01-25 ImMutriX Therapeutics, Inc. Method for extracorporeal treatment of preeclampsia and related disorders
US11744967B2 (en) 2017-09-26 2023-09-05 Shin Nippon Biomedical Laboratories, Ltd. Intranasal delivery devices

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI223598B (en) * 1998-06-22 2004-11-11 Pfizer Ireland Pharmaceuticals An intranasal pharmaceutical composition for the treatment of male erectile dysfunction or female sexual disorders, an intranasal delivery system or device and sildenafil mesylate
US6821975B1 (en) * 1999-08-03 2004-11-23 Lilly Icos Llc Beta-carboline drug products
US6465465B1 (en) * 2000-03-14 2002-10-15 Arzneimittelwerk Dresden Gmbh Process for the treatment of erectile dysfunction and product therefor
CN1638739A (zh) * 2000-08-18 2005-07-13 法玛西雅厄普约翰美国公司 治疗成瘾性障碍的化合物
CA2420597C (en) * 2000-08-31 2011-05-17 Rtp Pharma Inc. Milled particles
AU2002310086B2 (en) * 2001-05-24 2008-09-04 Alexza Pharmaceuticals, Inc. Delivery of erectile dysfunction drugs through an inhalation route
EA006213B1 (ru) * 2001-07-31 2005-10-27 Х. Лундбекк А/С Кристаллическая композиция, содержащая эсциталопрам
US20050042177A1 (en) * 2003-07-23 2005-02-24 Elan Pharma International Ltd. Novel compositions of sildenafil free base

Also Published As

Publication number Publication date
JP2008518041A (ja) 2008-05-29
WO2007027612A2 (en) 2007-03-08
CA2610668A1 (en) 2007-03-08
KR20070067173A (ko) 2007-06-27
EP1843770A2 (de) 2007-10-17
EP1843770B1 (de) 2008-06-18
ES2308750T3 (es) 2008-12-01
US20070098804A1 (en) 2007-05-03
BRPI0606122A2 (pt) 2009-06-02
DE602006001510D1 (de) 2008-07-31
WO2007027612A3 (en) 2007-08-02
IL185938A0 (en) 2008-08-07
PL1843770T3 (pl) 2008-10-31
PT1843770E (pt) 2008-08-05

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Legal Events

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