ATE397593T1 - Verfahren zur herstellung einer vorstufe von vitamin b1 - Google Patents
Verfahren zur herstellung einer vorstufe von vitamin b1Info
- Publication number
- ATE397593T1 ATE397593T1 AT06704494T AT06704494T ATE397593T1 AT E397593 T1 ATE397593 T1 AT E397593T1 AT 06704494 T AT06704494 T AT 06704494T AT 06704494 T AT06704494 T AT 06704494T AT E397593 T1 ATE397593 T1 AT E397593T1
- Authority
- AT
- Austria
- Prior art keywords
- vitamin
- precursor
- producing
- grewe
- hydrolyzing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002243 precursor Substances 0.000 title 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- OZOHTVFCSKFMLL-UHFFFAOYSA-N 4-amino-5-aminomethyl-2-methylpyrimidine Chemical compound CC1=NC=C(CN)C(N)=N1 OZOHTVFCSKFMLL-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910001854 alkali hydroxide Inorganic materials 0.000 abstract 1
- 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05001859 | 2005-01-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE397593T1 true ATE397593T1 (de) | 2008-06-15 |
Family
ID=36118080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06704494T ATE397593T1 (de) | 2005-01-28 | 2006-01-24 | Verfahren zur herstellung einer vorstufe von vitamin b1 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9108925B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1841745B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5191237B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101277352B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101111484B (cg-RX-API-DMAC7.html) |
| AT (1) | ATE397593T1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE602006001394D1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2308715T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2006079504A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007104442A2 (en) * | 2006-03-15 | 2007-09-20 | Dsm Ip Assets B.V. | Process for the manufacture of a precursor of vitamin b1 |
| JP5618306B2 (ja) * | 2008-07-22 | 2014-11-05 | ディーエスエム アイピー アセッツ ビー．ブイ． | 置換４−アミノ−ピリミジンの新規合成 |
| CN103896935B (zh) * | 2012-12-27 | 2016-08-10 | 江西天新药业有限公司 | 3-[(4-氨基-5-嘧啶基)甲基]-5-(2-羟乙基)-4-甲基噻唑硝酸盐的制备方法 |
| CN104326989B (zh) * | 2014-11-26 | 2016-04-27 | 江西天新药业有限公司 | 2-甲基-4-氨基-5-(氨基甲基)嘧啶的制备方法 |
| US9682216B2 (en) | 2014-12-05 | 2017-06-20 | Anchor Endovascular, Inc. | Anchor device for use with catheters |
| CN108546249B (zh) * | 2018-02-28 | 2021-10-01 | 东北制药集团股份有限公司 | 一种制备双胺嘧啶的方法 |
| CN109467553B (zh) * | 2018-12-24 | 2021-02-12 | 江苏兄弟维生素有限公司 | 一种甲酰嘧啶的提纯方法以及维生素b1合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2775592A (en) * | 1956-12-25 | Z-methyl - | ||
| EP0001760B1 (de) * | 1977-10-27 | 1981-01-07 | BASF Aktiengesellschaft | Alpha-aminomethylen-beta-formylaminopropionitril, Verfahren zu seiner Herstellung sowie Verwendung zur Herstellung von 2-Methyl-4-amino-5-formylaminomethyl-pyrimidin |
| JPS5576084A (en) * | 1978-12-01 | 1980-06-07 | Takeda Chem Ind Ltd | Method and apparatus for production of vitamin b1 and intermediate thereof |
| DE3511273A1 (de) * | 1985-03-28 | 1986-10-09 | Basf Ag, 6700 Ludwigshafen | Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin |
| DE10015470A1 (de) * | 2000-03-29 | 2001-10-11 | Basf Ag | Verfahren zur Herstellung von 2-Methyl-4-amino-5-aminomethyrimidin |
-
2006
- 2006-01-24 DE DE200660001394 patent/DE602006001394D1/de active Active
- 2006-01-24 AT AT06704494T patent/ATE397593T1/de not_active IP Right Cessation
- 2006-01-24 WO PCT/EP2006/000600 patent/WO2006079504A2/en not_active Ceased
- 2006-01-24 KR KR1020077017242A patent/KR101277352B1/ko active Active
- 2006-01-24 EP EP20060704494 patent/EP1841745B1/en active Active
- 2006-01-24 JP JP2007552562A patent/JP5191237B2/ja not_active Expired - Fee Related
- 2006-01-24 US US11/795,957 patent/US9108925B2/en active Active
- 2006-01-24 CN CN2006800034976A patent/CN101111484B/zh active Active
- 2006-01-24 ES ES06704494T patent/ES2308715T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008528529A (ja) | 2008-07-31 |
| CN101111484A (zh) | 2008-01-23 |
| ES2308715T3 (es) | 2008-12-01 |
| WO2006079504A2 (en) | 2006-08-03 |
| DE602006001394D1 (de) | 2008-07-17 |
| EP1841745B1 (en) | 2008-06-04 |
| JP5191237B2 (ja) | 2013-05-08 |
| CN101111484B (zh) | 2013-07-24 |
| US9108925B2 (en) | 2015-08-18 |
| WO2006079504A3 (en) | 2007-02-15 |
| KR20070098888A (ko) | 2007-10-05 |
| EP1841745A2 (en) | 2007-10-10 |
| US20080242863A1 (en) | 2008-10-02 |
| KR101277352B1 (ko) | 2013-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2009001816A (es) | Procedimiento para la produccion de acido d,l-2-hidroxi-4-alquilti o butirico. | |
| NZ600035A (en) | Method for preparing pyrrolobenzodiazepines, particularly zc-423 | |
| NZ592497A (en) | Derivatives of 1-amino-2-cyclobutylethylboronic acid | |
| AR063710A1 (es) | Proceso para la preparacion de acido 6-(3-cloro-2-fluorbencil)-1-[(s)-1-hidroximetil-2-metilpropil]-7-metoxi-4-oxo-1, 4-dihidroquinolon-3-carboxilico como inhibidores de integrasa del hiv e intermediarios de sintesis del mismo y composiciones que lo comprenden. | |
| NZ600119A (en) | Process and intermediates for the preparation of 5-biphenyl-4-yl-2-methylpentanoic acid derivatives | |
| ATE478043T1 (de) | Verfahren zur herstellung von acylperoxiden | |
| MX2009003823A (es) | Nueva difenilazetidinona sustituida con acido piperazina-1-sulfonico y que tiene propiedades farmacologicas mejoradas. | |
| CL2004000687A1 (es) | Procedimiento para la preparacion de telmisartan. | |
| WO2008108409A1 (ja) | 第四級アンモニウム塩をゲスト化合物とする包接水和物 | |
| ATE520649T1 (de) | Verfahren zur herstellung von nebenproduktarmen methylglycin-n,n-diessigsäure- trialkalimetallsalzen | |
| NZ601040A (en) | Method of producing acrylic and methacrylic acid | |
| ATE397593T1 (de) | Verfahren zur herstellung einer vorstufe von vitamin b1 | |
| EP1950208A4 (en) | Process for producing 6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one | |
| ATE512994T1 (de) | Hocheffizientes verfahren zur herstellung von polyalkylenoxidcarbonsäuren | |
| DE602007007824D1 (de) | Verfahren zur herstellung von abacavir | |
| DE602007005077D1 (de) | Verfahren zur Herstellung von Pyridinmethylsulphinylverbindungen | |
| AR057345A1 (es) | Proceso para preparar sales de acido cianhidrico | |
| ATE517890T1 (de) | Verfahren zur herstellung von reinem irbesartan | |
| DE602005013007D1 (de) | Verfahren zur herstellung von lactonen | |
| AR054874A1 (es) | Metodo para producir un derivado de 5- hidroxi -1-alquilpirazol | |
| EP1666440A4 (en) | METHOD FOR PRODUCING AN AROMATICALLY UNSATURATED COMPOUND | |
| BR112012015708A2 (pt) | novo processo para produção de 4-aminobut-2-enolidas a partir de 4-alcoxifuran-2 (5h) -ona ou 4-arilalcoxfuran-2 (5h) -ona | |
| DE602004030091D1 (de) | Verfahren zur reduktiven deshalogenierung | |
| ATE337842T1 (de) | Verfahren zur herstellung einer spezifischen kristallmodifikation von 2-(2-chlor-4-mesyl- benzoyl)-cyclohexan-1,3-dion | |
| ATE465999T1 (de) | Verfahren zur herstellung substituierter pyrimidine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |