ATE397251T1 - Verfahren für das entwerfen von kleinen erythropoietin mimetika - Google Patents

Verfahren für das entwerfen von kleinen erythropoietin mimetika

Info

Publication number
ATE397251T1
ATE397251T1 AT97922545T AT97922545T ATE397251T1 AT E397251 T1 ATE397251 T1 AT E397251T1 AT 97922545 T AT97922545 T AT 97922545T AT 97922545 T AT97922545 T AT 97922545T AT E397251 T1 ATE397251 T1 AT E397251T1
Authority
AT
Austria
Prior art keywords
epo
erythropoietin
designing small
erythropoietin mimetics
mimetics
Prior art date
Application number
AT97922545T
Other languages
English (en)
Inventor
Ian Wilson
Oded Livnah
Enrico Stura
Dana Johnson
Linda Jolliffe
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE397251T1 publication Critical patent/ATE397251T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/746—Erythropoetin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S707/00—Data processing: database and file management or data structures
    • Y10S707/99941—Database schema or data structure
    • Y10S707/99943—Generating database or data structure, e.g. via user interface

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97922545T 1996-04-26 1997-04-28 Verfahren für das entwerfen von kleinen erythropoietin mimetika ATE397251T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/641,071 US5835382A (en) 1996-04-26 1996-04-26 Small molecule mimetics of erythropoietin

Publications (1)

Publication Number Publication Date
ATE397251T1 true ATE397251T1 (de) 2008-06-15

Family

ID=24570833

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97922545T ATE397251T1 (de) 1996-04-26 1997-04-28 Verfahren für das entwerfen von kleinen erythropoietin mimetika

Country Status (13)

Country Link
US (4) US5835382A (de)
EP (1) EP1012741B1 (de)
JP (1) JP2000509393A (de)
KR (1) KR100458755B1 (de)
CN (1) CN1114876C (de)
AT (1) ATE397251T1 (de)
AU (1) AU709679B2 (de)
CA (1) CA2251842C (de)
DE (1) DE69738739D1 (de)
IL (1) IL126566A (de)
NZ (2) NZ332181A (de)
RU (1) RU2200347C2 (de)
WO (1) WO1997041526A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI0833934T2 (sl) 1995-06-15 2013-04-30 Crucell Holland B.V. Pakirni sistemi za humani rekombinantni adenovirus za uporabo v genski terapiji
US5835382A (en) * 1996-04-26 1998-11-10 The Scripps Research Institute Small molecule mimetics of erythropoietin
US6221608B1 (en) * 1997-01-22 2001-04-24 Ortho Pharmaceutical Corporation Methods for identifying erythropoietin receptor binding protein
PT1073623E (pt) * 1998-04-20 2007-05-31 Ortho Mcneil Pharm Inc Aminoácidos substituídos como miméticos da eritropoietina.
AUPP660698A0 (en) * 1998-10-21 1998-11-12 University Of Queensland, The A method of protein engineering
US7345019B1 (en) 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US7410941B1 (en) 1999-04-13 2008-08-12 The Kenneth S. Warren Institute, Inc. Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US6855544B1 (en) * 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
US8236561B2 (en) * 1999-04-15 2012-08-07 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
US20050170463A1 (en) * 1999-04-15 2005-08-04 Abraham Bout Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus E1A and E1B proteins
US7604960B2 (en) * 1999-04-15 2009-10-20 Crucell Holland B.V. Transient protein expression methods
US20050164386A1 (en) * 1999-04-15 2005-07-28 Uytdehaag Alphonsus G. Overexpression of enzymes involved in post-translational protein modifications in human cells
US7527961B2 (en) * 1999-11-26 2009-05-05 Crucell Holland B.V. Production of vaccines
US7521220B2 (en) 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
US7192759B1 (en) * 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
US20020037832A1 (en) * 2000-05-02 2002-03-28 Soren Nielsen Use of alpha-MSH and EPO for preventing or treating ischemic conditions
AUPR030900A0 (en) 2000-09-22 2000-10-12 Queensland University Of Technology Growth factor complex
WO2002046392A2 (en) 2000-12-09 2002-06-13 The Regents Of The University Of California X ray crystal structures at 5.5 a resolution of functional complexes of the bacterial ribosome containing transfer rna and model messenger rnas
US20030072737A1 (en) 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
US7767643B2 (en) * 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
PA8536201A1 (es) 2000-12-29 2002-08-29 Kenneth S Warren Inst Inc Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina
US6531121B2 (en) * 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
KR100979025B1 (ko) * 2001-12-07 2010-08-30 크루셀 홀란드 비.브이. 바이러스, 바이러스 단리물 및 백신의 생산
US7300915B2 (en) 2002-06-05 2007-11-27 The Regents Of The University Of California Use of erythropoietin and erythropoietin mimetics for the treatment of neuropathic pain
CA2491567A1 (en) * 2002-07-01 2004-01-08 The Kenneth S. Warren Institute, Inc. Recombinant tissue protective cytokines and encoding nucleic acids thereof for protection, restoration, and enhancement of responsive cells, tissues, and organs
AU2003900481A0 (en) 2003-02-05 2003-02-20 Queensland University Of Technology Synthetic modulators of cell migration and growth
US20100143442A1 (en) 2003-02-05 2010-06-10 Queensland University Of Technology Growth factor complexes and modulation of cell migration and growth
CN100383238C (zh) * 2003-05-09 2008-04-23 克鲁塞尔荷兰公司 E1-永生化的细胞培养物及培养所述细胞以提高从中获取的产物产量的方法
EP1626992B1 (de) * 2003-05-23 2010-06-02 Crucell Holland B.V. Herstellung von rekombinanten igm in den per.c6 zellen
BRPI0414887A (pt) * 2003-09-29 2006-12-12 Warren Pharmaceuticals Inc E T métodos de tratamento, prevenção, retardo do inìcio ou redução dos efeitos de citocinas pró-inflamatórias em um mamìfero e de tratamento, prevenção, retardo do inìcio de uma condição associada com um efeito de citocinas pró-inflamatórias em um mamìfero, e, composição farmacêutica
WO2005037304A1 (en) * 2003-10-17 2005-04-28 Crucell Holland B.V. Treatment and prevention of decubitus
EP1833964B1 (de) 2004-12-17 2013-05-22 Monash University Regulation der metalloproteasespaltung von zelloberflächenproteinen durch adam10
RU2285300C1 (ru) * 2005-02-02 2006-10-10 ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук (НИИ фармакологии ТНЦ СО РАН) Способ коррекции нарушений эритропоэза при экспериментальной гипоксии
WO2008057537A2 (en) * 2006-11-08 2008-05-15 Maine Medical Center Research System and method for identifying erythropoietin-responsive genes
EP2121017A2 (de) * 2006-12-19 2009-11-25 Nokad Verfahren zur unterdrückung der expression von endogenem erythropoetin (epo)
WO2008154456A2 (en) * 2007-06-06 2008-12-18 Nationwide Children's Hospital, Inc. Methods and compositions relating to viral fusion proteins
WO2009088975A2 (en) * 2008-01-04 2009-07-16 Biotrofix, Inc. Methods and compositions for non-covalently enhanced receptor binding
WO2009094172A2 (en) 2008-01-22 2009-07-30 Araim Pharmaceuticals, Inc. Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
WO2010099019A1 (en) 2009-02-24 2010-09-02 Alexion Pharmaceuticals, Inc. Antibodies containing therapeutic tpo/epo mimetic peptides
EP2253715A1 (de) 2009-05-14 2010-11-24 RWTH Aachen Neue Targets zur Krebstherapie und/oder -diagnose
RU2012127364A (ru) 2009-11-30 2014-01-10 Квинсленд Юниверсити Оф Текнолоджи Химеры фибронектин: фактор роста

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4674066A (en) 1983-02-18 1987-06-16 Houghton Mifflin Company Textual database system using skeletonization and phonetic replacement to retrieve words matching or similar to query words
US5265030A (en) * 1990-04-24 1993-11-23 Scripps Clinic And Research Foundation System and method for determining three-dimensional structures of proteins
US5292654A (en) * 1990-12-13 1994-03-08 Whitehead Institute For Biomedical Research Mutant EPO receptor and uses therefor
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JP3417558B2 (ja) * 1991-05-10 2003-06-16 ジェネンテク，インコーポレイテッド 配位子作用薬および拮抗薬の選択
AU2408292A (en) * 1991-07-11 1993-02-11 Regents Of The University Of California, The A method to identify protein sequences that fold into a known three-dimensional structure
US5386507A (en) * 1991-07-18 1995-01-31 Teig; Steven L. Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5453937A (en) * 1993-04-28 1995-09-26 Immunex Corporation Method and system for protein modeling
HUT73876A (en) * 1993-04-29 1996-10-28 Abbott Lab Erythropoietin analog compositions and methods
US5434796A (en) * 1993-06-30 1995-07-18 Daylight Chemical Information Systems, Inc. Method and apparatus for designing molecules with desired properties by evolving successive populations
GB2298941B (en) 1993-10-22 1998-02-04 Fdc Inc Database using table rotation and bimapped queries
US5767078A (en) * 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
US5835382A (en) * 1996-04-26 1998-11-10 The Scripps Research Institute Small molecule mimetics of erythropoietin

Also Published As

Publication number Publication date
EP1012741A4 (de) 2001-09-12
NZ332181A (en) 2000-05-26
CA2251842A1 (en) 1997-11-06
AU2818797A (en) 1997-11-19
EP1012741A1 (de) 2000-06-28
US7272508B2 (en) 2007-09-18
JP2000509393A (ja) 2000-07-25
US20090119019A1 (en) 2009-05-07
US20100250600A1 (en) 2010-09-30
KR20000065004A (ko) 2000-11-06
CN1114876C (zh) 2003-07-16
RU2200347C2 (ru) 2003-03-10
NZ513454A (en) 2004-12-24
AU709679B2 (en) 1999-09-02
CN1223732A (zh) 1999-07-21
WO1997041526A1 (en) 1997-11-06
US5835382A (en) 1998-11-10
EP1012741B1 (de) 2008-05-28
IL126566A (en) 2006-12-31
US20060064252A1 (en) 2006-03-23
IL126566A0 (en) 1999-08-17
DE69738739D1 (de) 2008-07-10
KR100458755B1 (ko) 2005-06-20
CA2251842C (en) 2008-09-09

Similar Documents

Publication Publication Date Title
ATE397251T1 (de) Verfahren für das entwerfen von kleinen erythropoietin mimetika
ATE246361T1 (de) Verfahren zur bestimmung von ige
ATE278805T1 (de) Verfahren zur quantifizierung von cholesterol in lipoproteinen und quantifizierungsreagenzien
ATE332368T1 (de) Selektion von proteinen mittels rns-protein fusionen
FI915150A7 (fi) Menetelmät, reagenssit ja testikäyttöpakkaukset biologisten yksiköiden alapopulaatioiden määrittämiseksi
BR9808313A (pt) Métodos para determinar a predisposição de um paciente à doença arterial coronariana e kit para previsão de doença arterial coronariana
PT807691E (pt) Metodo para a pesquisa quanto a presenca de um defeito genetico associado a trombose e/ou fraca resposta anticoagulante a proteina c activada
DE69823985D1 (de) Nachweis der krankheitsbedingten konformation eines proteins
DE69837015D1 (de) Verfahren zur Stabilisierung und Messung von Troponinkomplexen
DE69434942D1 (de) Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben
CY1112101T1 (el) Νευροτροφικοι παραγοντες
DK0590071T3 (da) Hovedsagelig rene receptor-lignende TGF-BETA-1 bindende molekyler samt anvendelse deraf
EP1687283A4 (de) Für die bestimmung von fk506 geeignetes verfahren und zusammensetzung
DE69433301D1 (de) Methoden zur erhöhung der biologischen aktivität von chemokinen
ES2047334T3 (es) Metodo de analisis optico.
ATE473294T1 (de) Verfahren und zusammensetzungen zur verwendung von mhc-klasse ii-invariante-kette-polypeptid als rezeptor für makrophagenwanderung-hemmfaktor
DK0975800T3 (da) Analyse af nukleotider i opløsning under anvendelse af PNA-prober
DE69822392D1 (de) System zur Beurteilung eines Merkmales einer optischen Faser und rechnerlesbares Aufzeichnungsmittel für das Aufzeichnen des vom System benutzten Rechnerprogramms
SE8505458L (sv) Bakteriofager som igenkennings- och identifieringsmedel
DE69821246D1 (de) Testverfahren für collagenpeptid
PT879296E (pt) Marcadores de adn para o tamanho da ninhada no suino
BR9007969A (pt) Processo para diagnosticar a presenca de um disturbio de anormalidade de metabolismo,composicao contendo anticorpo,anti-corpo monocloral,linha de celula imortalizada,processo para produzir anti-corpo monocloral,kit para determinacao de imuno-ensaio,e processo para determinar ruptura de tecido conjuntivo
DE69831229D1 (de) Schnelle bestimmung des verhältnisses von biologischen molekülen
DE69428278D1 (de) Leukozytadhaesiontest
ATE265533T1 (de) Saeugetierchemokine

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties