ATE397251T1 - Verfahren für das entwerfen von kleinen erythropoietin mimetika - Google Patents

Verfahren für das entwerfen von kleinen erythropoietin mimetika

Info

Publication number
ATE397251T1
ATE397251T1 AT97922545T AT97922545T ATE397251T1 AT E397251 T1 ATE397251 T1 AT E397251T1 AT 97922545 T AT97922545 T AT 97922545T AT 97922545 T AT97922545 T AT 97922545T AT E397251 T1 ATE397251 T1 AT E397251T1
Authority
AT
Austria
Prior art keywords
epo
erythropoietin
designing small
erythropoietin mimetics
mimetics
Prior art date
Application number
AT97922545T
Other languages
English (en)
Inventor
Ian Wilson
Oded Livnah
Enrico Stura
Dana Johnson
Linda Jolliffe
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE397251T1 publication Critical patent/ATE397251T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/746—Erythropoetin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S707/00—Data processing: database and file management or data structures
    • Y10S707/99941—Database schema or data structure
    • Y10S707/99943—Generating database or data structure, e.g. via user interface

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97922545T 1996-04-26 1997-04-28 Verfahren für das entwerfen von kleinen erythropoietin mimetika ATE397251T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/641,071 US5835382A (en) 1996-04-26 1996-04-26 Small molecule mimetics of erythropoietin

Publications (1)

Publication Number Publication Date
ATE397251T1 true ATE397251T1 (de) 2008-06-15

Family

ID=24570833

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97922545T ATE397251T1 (de) 1996-04-26 1997-04-28 Verfahren für das entwerfen von kleinen erythropoietin mimetika

Country Status (13)

Country Link
US (4) US5835382A (de)
EP (1) EP1012741B1 (de)
JP (1) JP2000509393A (de)
KR (1) KR100458755B1 (de)
CN (1) CN1114876C (de)
AT (1) ATE397251T1 (de)
AU (1) AU709679B2 (de)
CA (1) CA2251842C (de)
DE (1) DE69738739D1 (de)
IL (1) IL126566A (de)
NZ (2) NZ332181A (de)
RU (1) RU2200347C2 (de)
WO (1) WO1997041526A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT833934E (pt) 1995-06-15 2005-02-28 Crucell Holland Bv Sistemas de empacotamento para adenovivrus recombinente humano destinados a terapia genetica
US5835382A (en) * 1996-04-26 1998-11-10 The Scripps Research Institute Small molecule mimetics of erythropoietin
US6221608B1 (en) * 1997-01-22 2001-04-24 Ortho Pharmaceutical Corporation Methods for identifying erythropoietin receptor binding protein
WO1999054279A1 (en) * 1998-04-20 1999-10-28 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
AUPP660698A0 (en) 1998-10-21 1998-11-12 University Of Queensland, The A method of protein engineering
US7410941B1 (en) 1999-04-13 2008-08-12 The Kenneth S. Warren Institute, Inc. Methods for treatment of neurodegenerative conditions by peripherally administered erythropoietin
US7345019B1 (en) 1999-04-13 2008-03-18 The Kenneth S. Warren Institute, Inc. Modulation of excitable tissue function by peripherally administered erythropoietin
US8236561B2 (en) * 1999-04-15 2012-08-07 Crucell Holland B.V. Efficient production of IgA in recombinant mammalian cells
US20050170463A1 (en) * 1999-04-15 2005-08-04 Abraham Bout Recombinant protein production in permanent amniocytic cells that comprise nucleic acid encoding adenovirus E1A and E1B proteins
US7604960B2 (en) * 1999-04-15 2009-10-20 Crucell Holland B.V. Transient protein expression methods
US20050164386A1 (en) * 1999-04-15 2005-07-28 Uytdehaag Alphonsus G. Overexpression of enzymes involved in post-translational protein modifications in human cells
US6855544B1 (en) * 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
US7527961B2 (en) * 1999-11-26 2009-05-05 Crucell Holland B.V. Production of vaccines
US7192759B1 (en) * 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
US7521220B2 (en) * 1999-11-26 2009-04-21 Crucell Holland B.V. Production of vaccines
US20020037832A1 (en) * 2000-05-02 2002-03-28 Soren Nielsen Use of alpha-MSH and EPO for preventing or treating ischemic conditions
AUPR030900A0 (en) 2000-09-22 2000-10-12 Queensland University Of Technology Growth factor complex
WO2002046392A2 (en) 2000-12-09 2002-06-13 The Regents Of The University Of California X ray crystal structures at 5.5 a resolution of functional complexes of the bacterial ribosome containing transfer rna and model messenger rnas
PA8536201A1 (es) 2000-12-29 2002-08-29 Kenneth S Warren Inst Inc Protección y mejoramiento de células, tejidos y órganos que responden a la eritropoyetina
US7767643B2 (en) * 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
US6531121B2 (en) 2000-12-29 2003-03-11 The Kenneth S. Warren Institute, Inc. Protection and enhancement of erythropoietin-responsive cells, tissues and organs
US20030072737A1 (en) * 2000-12-29 2003-04-17 Michael Brines Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs
EP1465987B1 (de) * 2001-12-07 2008-01-23 Crucell Holland B.V. Herstellung von viren, virusisolaten, und impfstoffen
US7300915B2 (en) 2002-06-05 2007-11-27 The Regents Of The University Of California Use of erythropoietin and erythropoietin mimetics for the treatment of neuropathic pain
EA010200B1 (ru) * 2002-07-01 2008-06-30 Дзе Кеннет С. Уоррен Инститьют, Инк. Рекомбинантные тканезащитные цитокины и кодирующие их нуклеиновые кислоты для защиты, восстановления и усиления чувствительных клеток, тканей и органов
AU2003900481A0 (en) 2003-02-05 2003-02-20 Queensland University Of Technology Synthetic modulators of cell migration and growth
US20100143442A1 (en) 2003-02-05 2010-06-10 Queensland University Of Technology Growth factor complexes and modulation of cell migration and growth
CA2520891C (en) * 2003-05-09 2014-07-08 Crucell Holland B.V. Cultures of e1-immortalized cells and processes for culturing the same to increase product yields therefrom
CA2521490C (en) * 2003-05-23 2013-07-30 Crucell Holland B.V. Production of recombinant igm in per.c6 cells
AU2004277954A1 (en) * 2003-09-29 2005-04-14 The Kenneth S Warren Institute, Inc. Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
WO2005037304A1 (en) * 2003-10-17 2005-04-28 Crucell Holland B.V. Treatment and prevention of decubitus
WO2006063415A1 (en) 2004-12-17 2006-06-22 Monash University Regulation of metalloprotease cleavage of cell surface proteins
RU2285300C1 (ru) * 2005-02-02 2006-10-10 ГУ Научно-исследовательский институт фармакологии Томского научного центра Сибирского отделения Российской академии медицинских наук (НИИ фармакологии ТНЦ СО РАН) Способ коррекции нарушений эритропоэза при экспериментальной гипоксии
WO2008057537A2 (en) * 2006-11-08 2008-05-15 Maine Medical Center Research System and method for identifying erythropoietin-responsive genes
US20100115638A1 (en) * 2006-12-19 2010-05-06 Amina Abina Method for inhibiting the expression of endogenous erythropoietin (epo)
US20100261155A1 (en) * 2007-06-06 2010-10-14 Nationwide Children's Hospital, Inc. Methods and compositions relating to viral fusion proteins
CN101978266A (zh) * 2008-01-04 2011-02-16 拜尔特菲克斯有限公司 用于非共价增强受体结合的方法和组合物
NZ621196A (en) 2008-01-22 2015-08-28 Araim Pharmaceuticals Inc Tissue protective peptides and peptide analogs for preventing and treating diseases and disorders associated with tissue damage
KR20110122846A (ko) 2009-02-24 2011-11-11 알렉시온 파마슈티칼스, 인코포레이티드 치료용 ｔｐｏ/ｅｐｏ 모방 펩티드를 포함하는 항체
EP2253715A1 (de) 2009-05-14 2010-11-24 RWTH Aachen Neue Targets zur Krebstherapie und/oder -diagnose
NZ600454A (en) 2009-11-30 2014-10-31 Univ Queensland Fibronectin: growth factor chimeras

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4674066A (en) 1983-02-18 1987-06-16 Houghton Mifflin Company Textual database system using skeletonization and phonetic replacement to retrieve words matching or similar to query words
US5265030A (en) * 1990-04-24 1993-11-23 Scripps Clinic And Research Foundation System and method for determining three-dimensional structures of proteins
US5292654A (en) * 1990-12-13 1994-03-08 Whitehead Institute For Biomedical Research Mutant EPO receptor and uses therefor
US5331573A (en) * 1990-12-14 1994-07-19 Balaji Vitukudi N Method of design of compounds that mimic conformational features of selected peptides
JP3417558B2 (ja) * 1991-05-10 2003-06-16 ジェネンテク，インコーポレイテッド 配位子作用薬および拮抗薬の選択
AU2408292A (en) * 1991-07-11 1993-02-11 Regents Of The University Of California, The A method to identify protein sequences that fold into a known three-dimensional structure
US5386507A (en) * 1991-07-18 1995-01-31 Teig; Steven L. Computer graphics system for selectively modelling molecules and investigating the chemical and physical properties thereof
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
US5453937A (en) * 1993-04-28 1995-09-26 Immunex Corporation Method and system for protein modeling
FI955128L (fi) * 1993-04-29 1995-10-27 Abbott Lab Erytropoietiinianalogikoostumuksia ja menetelmä niiden valmistamiseksi ja käyttämiseksi
US5434796A (en) * 1993-06-30 1995-07-18 Daylight Chemical Information Systems, Inc. Method and apparatus for designing molecules with desired properties by evolving successive populations
WO1995011487A1 (en) 1993-10-22 1995-04-27 Fdc, Inc. Database using table rotation and bimapped queries
US5767078A (en) * 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
US5835382A (en) * 1996-04-26 1998-11-10 The Scripps Research Institute Small molecule mimetics of erythropoietin

Also Published As

Publication number Publication date
IL126566A (en) 2006-12-31
KR20000065004A (ko) 2000-11-06
US5835382A (en) 1998-11-10
CN1223732A (zh) 1999-07-21
RU2200347C2 (ru) 2003-03-10
NZ513454A (en) 2004-12-24
AU709679B2 (en) 1999-09-02
DE69738739D1 (de) 2008-07-10
CA2251842A1 (en) 1997-11-06
IL126566A0 (en) 1999-08-17
EP1012741A4 (de) 2001-09-12
US7272508B2 (en) 2007-09-18
WO1997041526A1 (en) 1997-11-06
EP1012741A1 (de) 2000-06-28
US20100250600A1 (en) 2010-09-30
CA2251842C (en) 2008-09-09
KR100458755B1 (ko) 2005-06-20
AU2818797A (en) 1997-11-19
NZ332181A (en) 2000-05-26
CN1114876C (zh) 2003-07-16
EP1012741B1 (de) 2008-05-28
US20090119019A1 (en) 2009-05-07
US20060064252A1 (en) 2006-03-23
JP2000509393A (ja) 2000-07-25

Similar Documents

Publication Publication Date Title
ATE397251T1 (de) Verfahren für das entwerfen von kleinen erythropoietin mimetika
ATE246361T1 (de) Verfahren zur bestimmung von ige
ATE278805T1 (de) Verfahren zur quantifizierung von cholesterol in lipoproteinen und quantifizierungsreagenzien
ATE332368T1 (de) Selektion von proteinen mittels rns-protein fusionen
FI915150A7 (fi) Menetelmät, reagenssit ja testikäyttöpakkaukset biologisten yksiköiden alapopulaatioiden määrittämiseksi
BR9808313A (pt) Métodos para determinar a predisposição de um paciente à doença arterial coronariana e kit para previsão de doença arterial coronariana
ATE540319T1 (de) Verfahren für die bestimmung von fk506
DE69823985D1 (de) Nachweis der krankheitsbedingten konformation eines proteins
ATE353138T1 (de) Verfahren zur stabilisierung und messung von troponinkomplexen
DE69434942D1 (de) Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben
FI954855A0 (fi) Menetelmä tromboosiin ja/tai huonoon antikoagulanttivasteeseen aktivoituun proteiini C:hen liittyvän geenivirheen läsnäolon seulomiseksi
DK0590071T3 (da) Hovedsagelig rene receptor-lignende TGF-BETA-1 bindende molekyler samt anvendelse deraf
ATE98773T1 (de) Verfahren zur optischen analyse.
DE69433301D1 (de) Methoden zur erhöhung der biologischen aktivität von chemokinen
DE68918103D1 (de) Verfahren zur überwachung des kollagenabbaus.
ATE473294T1 (de) Verfahren und zusammensetzungen zur verwendung von mhc-klasse ii-invariante-kette-polypeptid als rezeptor für makrophagenwanderung-hemmfaktor
DK0975800T3 (da) Analyse af nukleotider i opløsning under anvendelse af PNA-prober
ATE258310T1 (de) Testverfahren für collagenpeptid
SE8505458L (sv) Bakteriofager som igenkennings- och identifieringsmedel
DE69822392D1 (de) System zur Beurteilung eines Merkmales einer optischen Faser und rechnerlesbares Aufzeichnungsmittel für das Aufzeichnen des vom System benutzten Rechnerprogramms
PT879296E (pt) Marcadores de adn para o tamanho da ninhada no suino
ATE302413T1 (de) Schnelle bestimmung des verhältnisses von biologischen molekülen
DE69428278D1 (de) Leukozytadhaesiontest
DE69032329D1 (de) Für c.difficile spezifische oligonukleotide
DK1051491T3 (da) Equin Fc Epsilon receptor-alfa-kæde-nukleinsyremolekyler, korresponderende proteiner og anvendelse heraf

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties