ATE395975T1 - Mehrfachprobenfermentor und verfahren zu dessen verwendung - Google Patents

Mehrfachprobenfermentor und verfahren zu dessen verwendung

Info

Publication number
ATE395975T1
ATE395975T1 AT02707750T AT02707750T ATE395975T1 AT E395975 T1 ATE395975 T1 AT E395975T1 AT 02707750 T AT02707750 T AT 02707750T AT 02707750 T AT02707750 T AT 02707750T AT E395975 T1 ATE395975 T1 AT E395975T1
Authority
AT
Austria
Prior art keywords
fermentation
array
cannula
sample
vessel
Prior art date
Application number
AT02707750T
Other languages
English (en)
Inventor
Robert Downs
Scott Lesley
James Mainquist
Daniel Mcmullan
Andrew Meyer
Marc Nasoff
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Application granted granted Critical
Publication of ATE395975T1 publication Critical patent/ATE395975T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/08—Flask, bottle or test tube
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/48—Holding appliances; Racks; Supports
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B01J2219/00493—Means for mixing reactants or products in the reaction vessels by sparging or bubbling with gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/802—Logarithmic growth phase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/808—Optical sensing apparatus
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/813—Continuous fermentation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/818—Aeration or oxygen transfer technique

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Sustainable Development (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Thermal Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Steroid Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02707750T 2001-02-08 2002-02-08 Mehrfachprobenfermentor und verfahren zu dessen verwendung ATE395975T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/780,591 US6635441B2 (en) 2001-02-08 2001-02-08 Multi-sample fermentor and method of using same

Publications (1)

Publication Number Publication Date
ATE395975T1 true ATE395975T1 (de) 2008-06-15

Family

ID=25120024

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02707750T ATE395975T1 (de) 2001-02-08 2002-02-08 Mehrfachprobenfermentor und verfahren zu dessen verwendung

Country Status (7)

Country Link
US (3) US6635441B2 (de)
EP (1) EP1362115B1 (de)
JP (1) JP2004536567A (de)
AT (1) ATE395975T1 (de)
CA (1) CA2435814A1 (de)
DE (1) DE60226705D1 (de)
WO (1) WO2002063027A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6869792B2 (en) 2001-03-16 2005-03-22 Irm, Llc Method and apparatus for performing multiple processing steps on a sample in a single vessel
US6659142B2 (en) 2001-03-27 2003-12-09 Irm, Llc Apparatus and method for preparing fluid mixtures
ES2208127B1 (es) * 2002-11-28 2005-09-01 Universitat Politecnica De Catalunya Sistema modular de multiples minibiorreactores automatizados para screenning multifuncional (hts) en biotecnologia.
DE10304855A1 (de) * 2003-02-06 2004-08-26 Hte Ag The High Throughput Experimentation Company Vorrichtung und Verfahren zum simultanen Agitieren von Reaktionsmischungen
EP1516920A1 (de) * 2003-09-19 2005-03-23 The Automation Partnership Zellkulturgefäss für die automatische Verarbeitung von Zellkulturen
US7374725B2 (en) * 2004-02-11 2008-05-20 Gener8, Inc. Well plate reactor
FI118192B (fi) * 2004-11-03 2007-08-15 Medicel Oy Reaktorilaite
WO2006102416A2 (en) * 2005-03-22 2006-09-28 Irm Llc Compound profiling devices, systems, and related methods
JP5150837B2 (ja) * 2006-04-11 2013-02-27 ウイリアム エー．クック オーストラリア ピティワイ、リミティド． 培養状態監視装置
DE102006040562B8 (de) * 2006-08-30 2014-09-04 Pieter Van Weenen & Co. Gmbh The House Of Innovation Begasungssystem und -verfahren
DE202007002538U1 (de) 2007-02-21 2007-06-06 Krebs, Torsten Begasungsvorrichtung und -system
DE102008028867B3 (de) * 2008-06-19 2009-11-12 Huppmann Gmbh Austrebereinrichtug für einen Läuterbottich
EP2270129B1 (de) * 2009-07-01 2017-11-29 The Automation Partnership (Cambridge) Limited Bioreaktorsystem und zugehörige verfahren zur verarbeitung von bioreaktorgefässen
EP2564190A4 (de) * 2010-04-30 2013-12-25 Merck Sharp & Dohme Mehrlochplattenreaktor und system dafür
US10545494B2 (en) * 2010-06-18 2020-01-28 Rockwell Automation Technologies, Inc. Determining performance characteristics of a fermenter batch of a biofuel production plant
US8673224B2 (en) 2010-10-12 2014-03-18 Wildcat Discovery Technologies, Inc. Apparatus for synthesis and assaying of materials
US8183035B1 (en) 2011-09-07 2012-05-22 Therapeutic Proteins International, LLC Single container manufacturing of biological product
ITBO20130257A1 (it) * 2013-05-24 2014-11-25 Enologica Lucchi S R L Apparecchiatura per la gestione della fermentazione alcolica di prodotti vegetali
WO2015175943A1 (en) * 2014-05-16 2015-11-19 Saint-Gobain Performance Plastics Corporation Manufacturing article
KR101654559B1 (ko) * 2014-12-30 2016-09-22 (주)씨엔에스 세포 배양장치
CN106318854B (zh) * 2015-06-26 2018-12-25 中国石油化工股份有限公司 一种便于观测和取样的微生物反应装置及使用方法

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3843809A (en) 1972-08-23 1974-10-22 E Luck Manufacture of alcoholic beverages
US4033825A (en) 1973-05-31 1977-07-05 Instrumentation Laboratory, Inc. Cell culture system
US3997396A (en) 1973-07-02 1976-12-14 Monsanto Company Method for the in vitro propagation and maintenance of cells
US4201845A (en) 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
US4519984A (en) * 1982-01-18 1985-05-28 Phillips Petroleum Company Apparatus for carrying out sparged reaction
FR2565598B1 (fr) 1984-06-06 1986-10-03 Inst Nat Sante Rech Med Appareil modulaire pour la culture cellulaire
JPH078231B2 (ja) 1985-03-25 1995-02-01 株式会社日立製作所 培養制御方法及び培養制御装置
US4771187A (en) * 1985-05-17 1988-09-13 Nec Corporation Bistable circuit
US4680266A (en) 1985-11-21 1987-07-14 Contraves Ag Cell culture chamber with means for automatic replenishment of nutrient
DE3612453A1 (de) 1986-04-14 1987-10-15 Diessel Gmbh & Co Vorrichtung zur kultivierung von zellkulturen
DE3707368A1 (de) * 1987-03-07 1988-09-15 Hoechst Ag Vorrichtung zum thermostatisieren und mischen des inhaltes von gefaessen einer mikrotitrationsplatte
DE3739650C1 (de) 1987-11-23 1989-05-24 Immuno Ag Fermenter zum Zuechten von Zellkulturen
JPH01206989A (ja) 1988-02-16 1989-08-21 Snow Brand Milk Prod Co Ltd 細胞培養槽
US5416022A (en) 1988-08-10 1995-05-16 Cellex Biosciences, Inc. Cell culture apparatus
JPH02109966A (ja) 1988-10-20 1990-04-23 Kirin Brewery Co Ltd ラジアルフロー式充填層型バイオリアクタ
WO1991002049A1 (en) 1989-08-04 1991-02-21 Peter Grandics An integrated cell culture-protein purification system for the automated production and purification of cell culture products
IL102189A (en) * 1992-06-12 1995-07-31 Univ Ben Gurion Device for growing microorganisms
US5702672A (en) * 1992-10-08 1997-12-30 Warner-Lambert Company Apparatus and method for multiple simultaneous synthesis
US5443985A (en) 1993-07-22 1995-08-22 Alberta Research Council Cell culture bioreactor
WO1996005285A1 (en) * 1994-08-16 1996-02-22 Powell Biological Machines Ltd. Cell culture apparatus
AU4253996A (en) 1994-12-13 1996-07-03 Kjaergaard Industri-Automatic A/S A method and an apparatus for identifying foreign bodies in packaged beverages, as well as use of the apparatus
US6146534A (en) * 1996-08-19 2000-11-14 Reilly Industries, Inc. Thermally-managed separation and dewatering processes for recovering acid products
US5622819A (en) 1995-03-28 1997-04-22 Kinetic Biosystems, Inc. Centrifugal fermentation process
DE19529099C2 (de) * 1995-08-08 1997-12-04 Forschungszentrum Juelich Gmbh Vorrichtung zur Serien-Kultivierung von Mikroorganismen bzw. Zellen in begasten Flüssigkeitssäulen
WO1997022002A1 (de) * 1995-12-08 1997-06-19 Reimann Hans Juergen Verfahren und vorrichtung zur in-vitro diagnose allergischer erkrankungen
US5686304A (en) 1995-12-15 1997-11-11 Avecor Cardiovascular, Inc. Cell culture apparatus and method
IL119310A (en) * 1996-09-26 1999-07-14 Metabogal Ltd Cell/tissue culturing device and method
US6008010A (en) 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
EP0990142A4 (de) * 1996-12-31 2000-09-27 Genometrix Genomics Inc Molekulares multiplexanalyse verfahren und vorrichtung dazu
DE19712575C2 (de) * 1997-03-26 2000-05-11 Desaga Gmbh C Inkubationsvorrichtung
US5989913A (en) 1998-07-02 1999-11-23 Charles Daniel Anderson Culture vessel for growing or culturing cells, cellular aggregates, tissues and organoids and methods for using the same

Also Published As

Publication number Publication date
WO2002063027A1 (en) 2002-08-15
US20030157591A1 (en) 2003-08-21
US20040157322A1 (en) 2004-08-12
EP1362115B1 (de) 2008-05-21
DE60226705D1 (de) 2008-07-03
CA2435814A1 (en) 2002-08-15
US6723555B2 (en) 2004-04-20
JP2004536567A (ja) 2004-12-09
EP1362115A4 (de) 2004-06-23
US20020146818A1 (en) 2002-10-10
US6635441B2 (en) 2003-10-21
EP1362115A1 (de) 2003-11-19

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