ATE39251T1 - 3-(4-piperidyl)-1,2-benzisoxazole, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. - Google Patents
3-(4-piperidyl)-1,2-benzisoxazole, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.Info
- Publication number
- ATE39251T1 ATE39251T1 AT82110318T AT82110318T ATE39251T1 AT E39251 T1 ATE39251 T1 AT E39251T1 AT 82110318 T AT82110318 T AT 82110318T AT 82110318 T AT82110318 T AT 82110318T AT E39251 T1 ATE39251 T1 AT E39251T1
- Authority
- AT
- Austria
- Prior art keywords
- piperidyl
- preparation
- benzisoxazole
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
- C07D211/28—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms to which a second hetero atom is attached
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/319,871 US4355037A (en) | 1981-11-12 | 1981-11-12 | 3-(4-Piperidyl)-1,2-benzisoxales |
EP82110318A EP0080104B1 (de) | 1981-11-12 | 1982-11-09 | 3-(4-Piperidyl)-1,2-benzisoxazole, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE39251T1 true ATE39251T1 (de) | 1988-12-15 |
Family
ID=23243957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT82110318T ATE39251T1 (de) | 1981-11-12 | 1982-11-09 | 3-(4-piperidyl)-1,2-benzisoxazole, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4355037A (de) |
EP (1) | EP0080104B1 (de) |
JP (1) | JPS5890582A (de) |
KR (1) | KR880002012B1 (de) |
AT (1) | ATE39251T1 (de) |
AU (2) | AU567865B2 (de) |
CA (1) | CA1215066A (de) |
DE (1) | DE3279282D1 (de) |
ES (3) | ES8405791A1 (de) |
IE (1) | IE54857B1 (de) |
ZA (1) | ZA828281B (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5835177A (ja) * | 1981-08-26 | 1983-03-01 | Dainippon Pharmaceut Co Ltd | 2−環状アミノ−2−(1,2−ベンズイソキサゾ−ル−3−イル)酢酸エステル類並びにその酸付加塩類および第4級アンモニウム塩類 |
US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
US4408054A (en) * | 1981-11-12 | 1983-10-04 | Hoechst-Roussel Pharmaceuticals Inc. | Oximes of 4-benzoyl-piperidines |
US4528376A (en) * | 1982-08-11 | 1985-07-09 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(4-Piperidyl)-1,2-benzisoxazoles |
US4458076A (en) * | 1983-05-31 | 1984-07-03 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidinyl)-1,2-benzisothiazoles |
US4528292A (en) * | 1984-04-23 | 1985-07-09 | Hoechst-Roussel Pharmaceuticals Inc. | Antihypertensive 1,2-benzisothiazole piperidines |
US4590196A (en) * | 1984-08-23 | 1986-05-20 | Bristol-Myers Company | Analgesic 1,2-benzisothiazol-3-ylpiperazine derivatives |
ATE61054T1 (de) * | 1985-01-23 | 1991-03-15 | Hoechst Roussel Pharma | 3-piperidinyl- 1h-indazole, verfahren zu deren herstellung und deren anwendung als arzneimittel. |
US5057611A (en) * | 1985-04-22 | 1991-10-15 | Hoechst-Roussel Pharmaceuticals Inc. | Benzoylpiperidines |
EP0243184A3 (de) * | 1986-04-25 | 1989-05-10 | Roussel-Uclaf | Pestizide Verbindungen |
JPS63185141A (ja) * | 1987-01-27 | 1988-07-30 | Daikin Ind Ltd | 空気調和機のデ−タ伝送方式 |
CA1335289C (en) * | 1987-10-26 | 1995-04-18 | Fujio Antoku | Piperidinyl benzisoxazole derivatives, their production and pharmaceutical use |
GR1000667B (el) * | 1988-03-21 | 1992-09-25 | Janssen Pharmaceutica Nv | Μεθοδος παρασκευης 3-πιπεριδινυλο-1,2-βενζισοξαζολων. |
FR2641278B1 (fr) * | 1989-01-05 | 1991-03-22 | Lipha | Piperidines, procedes de preparation et medicaments les contenant |
US5561128A (en) * | 1989-05-19 | 1996-10-01 | Hoechst-Roussel Pharmaceuticals, Inc. | N-[(4-(heteroaryl)-1-piperidinyl)alkyl]-10,11-dihydro-5H-dibenz[B,F]azepines and related compounds and their therapeutic utility |
ATE126512T1 (de) * | 1989-05-19 | 1995-09-15 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und - heteroarylpiperazine, verfahren zu ihrer herstellung und ihre verwendung als medikamente. |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5776963A (en) * | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
FR2654104B1 (fr) * | 1989-11-07 | 1992-01-03 | Adir | Nouveaux derives du 1,2-benzisoxazole, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
NZ236501A (en) * | 1989-12-21 | 1992-12-23 | Merrell Dow Pharma | Piperidine derivatives and antithrombotic compositions |
FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
JP2800953B2 (ja) * | 1990-07-06 | 1998-09-21 | 住友製薬株式会社 | 新規なイミド誘導体 |
US5055476A (en) * | 1990-08-13 | 1991-10-08 | Hoechst-Roussel Pharmaceuticals Incorporated | 3-(1,2-benzisoxazol-3-yl)-4-pyridinamines and derivatives |
US7091199B1 (en) | 1999-09-14 | 2006-08-15 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4 antagonists |
US7253165B2 (en) * | 1999-09-14 | 2007-08-07 | Aventis Pharmaceuticals Inc. | Benzisoxazolyl-, pyridoisoxazolyl-and benzthienyl-phenoxy derivatives useful as D4 antagonists |
US7125903B1 (en) | 1999-09-14 | 2006-10-24 | Aventis Pharmaceuticals Inc. | Thienoisoxazolyl-and thienylpyrrazolyl-phenoxy substituted propyl derivatives useful as D4 antagonists |
DE60009959T2 (de) | 2000-05-05 | 2005-03-31 | Rpg Life Sciences Limited | Verfahren zur herstellung von antipsychotischem 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-on |
CN111518019B (zh) * | 2019-02-01 | 2023-10-24 | 江苏豪森药业集团有限公司 | 一种棕榈酸帕里哌酮中间体的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2517695A (en) * | 1945-07-13 | 1950-08-08 | Ciba Pharm Prod Inc | Production of 1-alkyl 4-phenylpiperidyl 4-ketones |
JPS5545545B2 (de) * | 1972-03-17 | 1980-11-18 | ||
DE2245971A1 (de) * | 1972-07-13 | 1974-03-14 | Merck Patent Gmbh | Isoxazolderivate und verfahren zu ihrer herstellung |
US4217349A (en) * | 1974-07-01 | 1980-08-12 | Sumitomo Chemical Company, Limited | Benzisoxazole derivatives |
US4335127A (en) * | 1979-01-08 | 1982-06-15 | Janssen Pharmaceutica, N.V. | Piperidinylalkyl quinazoline compounds, composition and method of use |
US4342870A (en) * | 1980-03-28 | 1982-08-03 | Janssen Pharmaceutica N.V. | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
US4352811A (en) * | 1981-11-12 | 1982-10-05 | Hoechst-Roussel Pharmaceuticals Inc. | 3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles |
-
1981
- 1981-11-12 US US06/319,871 patent/US4355037A/en not_active Expired - Lifetime
-
1982
- 1982-11-09 DE DE8282110318T patent/DE3279282D1/de not_active Expired
- 1982-11-09 AT AT82110318T patent/ATE39251T1/de not_active IP Right Cessation
- 1982-11-09 EP EP82110318A patent/EP0080104B1/de not_active Expired
- 1982-11-10 CA CA000415352A patent/CA1215066A/en not_active Expired
- 1982-11-10 KR KR8205082A patent/KR880002012B1/ko active
- 1982-11-10 ES ES517245A patent/ES8405791A1/es not_active Expired
- 1982-11-11 JP JP57196885A patent/JPS5890582A/ja active Granted
- 1982-11-11 IE IE2684/82A patent/IE54857B1/en not_active IP Right Cessation
- 1982-11-11 AU AU90390/82A patent/AU567865B2/en not_active Ceased
- 1982-11-11 ZA ZA828281A patent/ZA828281B/xx unknown
-
1984
- 1984-02-01 ES ES529369A patent/ES8601193A1/es not_active Expired
- 1984-02-01 ES ES529370A patent/ES529370A0/es active Granted
-
1988
- 1988-02-08 AU AU11385/88A patent/AU612621B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU612621B2 (en) | 1991-07-18 |
DE3279282D1 (en) | 1989-01-19 |
ES8507519A1 (es) | 1985-09-01 |
IE54857B1 (en) | 1990-02-28 |
AU9039082A (en) | 1983-05-19 |
EP0080104A2 (de) | 1983-06-01 |
EP0080104A3 (en) | 1983-08-24 |
IE822684L (en) | 1983-05-12 |
KR840002377A (ko) | 1984-06-25 |
ES517245A0 (es) | 1984-06-16 |
ZA828281B (en) | 1983-09-28 |
CA1215066A (en) | 1986-12-09 |
US4355037A (en) | 1982-10-19 |
ES529370A0 (es) | 1985-09-01 |
JPH0411546B2 (de) | 1992-02-28 |
ES529369A0 (es) | 1985-09-16 |
AU567865B2 (en) | 1987-12-10 |
KR880002012B1 (ko) | 1988-10-12 |
JPS5890582A (ja) | 1983-05-30 |
EP0080104B1 (de) | 1988-12-14 |
ES8405791A1 (es) | 1984-06-16 |
ES8601193A1 (es) | 1985-09-16 |
AU1138588A (en) | 1988-05-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |