ATE387197T1 - Cyanoalkylamino-derivate als protease-hemmer - Google Patents

Cyanoalkylamino-derivate als protease-hemmer

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Publication number
ATE387197T1
ATE387197T1 AT02789611T AT02789611T ATE387197T1 AT E387197 T1 ATE387197 T1 AT E387197T1 AT 02789611 T AT02789611 T AT 02789611T AT 02789611 T AT02789611 T AT 02789611T AT E387197 T1 ATE387197 T1 AT E387197T1
Authority
AT
Austria
Prior art keywords
cyanoalkylamino
derivatives
protease inhibitors
compounds
cysteine protease
Prior art date
Application number
AT02789611T
Other languages
German (de)
English (en)
Inventor
Cameron Black
Sheldon Crane
Dana Davis
Eduardo Setti
Original Assignee
Merck Frosst Canada Ltd
Axys Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Frosst Canada Ltd, Axys Pharm Inc filed Critical Merck Frosst Canada Ltd
Application granted granted Critical
Publication of ATE387197T1 publication Critical patent/ATE387197T1/de

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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AT02789611T 2001-11-13 2002-11-13 Cyanoalkylamino-derivate als protease-hemmer ATE387197T1 (de)

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US7371747B2 (en) 2008-05-13
US20050014941A1 (en) 2005-01-20
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WO2003041649A3 (en) 2003-07-31
JP4343690B2 (ja) 2009-10-14
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AU2002352663B2 (en) 2007-06-21
EP1446115A2 (en) 2004-08-18

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