ATE381616T1 - Regulation der upa gen-expression durch methylierte nukleotide - Google Patents

Regulation der upa gen-expression durch methylierte nukleotide

Info

Publication number
ATE381616T1
ATE381616T1 AT01953714T AT01953714T ATE381616T1 AT E381616 T1 ATE381616 T1 AT E381616T1 AT 01953714 T AT01953714 T AT 01953714T AT 01953714 T AT01953714 T AT 01953714T AT E381616 T1 ATE381616 T1 AT E381616T1
Authority
AT
Austria
Prior art keywords
sequence
target
regulation
oligonucleotide sequence
gene expression
Prior art date
Application number
AT01953714T
Other languages
German (de)
English (en)
Inventor
Shafaat Rabbani
Clarke Slemon
Original Assignee
Quebepharma Rech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quebepharma Rech Inc filed Critical Quebepharma Rech Inc
Application granted granted Critical
Publication of ATE381616T1 publication Critical patent/ATE381616T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21073—Serine endopeptidases (3.4.21) u-Plasminogen activator (3.4.21.73), i.e. urokinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT01953714T 2000-07-13 2001-07-13 Regulation der upa gen-expression durch methylierte nukleotide ATE381616T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA002312051A CA2312051A1 (en) 2000-07-13 2000-07-13 Methylated nucleotide regulation of gene expression

Publications (1)

Publication Number Publication Date
ATE381616T1 true ATE381616T1 (de) 2008-01-15

Family

ID=4166531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01953714T ATE381616T1 (de) 2000-07-13 2001-07-13 Regulation der upa gen-expression durch methylierte nukleotide

Country Status (9)

Country Link
US (1) US7316900B2 (enExample)
EP (1) EP1303599B1 (enExample)
JP (1) JP2004504028A (enExample)
AT (1) ATE381616T1 (enExample)
AU (2) AU7620501A (enExample)
CA (1) CA2312051A1 (enExample)
DE (1) DE60131973T2 (enExample)
ES (1) ES2298243T3 (enExample)
WO (1) WO2002006462A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2589986A1 (en) * 2004-12-07 2006-06-15 Releaf Security and storage system and method
FR2886946B1 (fr) * 2005-06-09 2007-08-10 Biomerieux Sa Procede pour le diagnoctic/pronostic du cancer du sein
US9023819B2 (en) * 2008-06-09 2015-05-05 National Chung Cheng University Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification
US20100161039A1 (en) 2008-12-23 2010-06-24 Vipul Dave Adhesion promoting temporary mask for coated surfaces
TWI393779B (zh) * 2009-10-16 2013-04-21 Nat Univ Chung Cheng 用於哺乳動物細胞的三元件基因表現報導系統及其應用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5000000A (en) * 1988-08-31 1991-03-19 University Of Florida Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes
US5840497A (en) 1993-06-11 1998-11-24 The Commonwealth Of Australia Commonwealth Scientific And Industrial Research Organization Method for specific silencing of genes by DNA methylation
US5552390A (en) * 1993-12-09 1996-09-03 The Board Of Regents Of The University Of Nebraska Phosphorothioate inhibitors of metastatic breast cancer
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5874416A (en) 1997-11-07 1999-02-23 Sheikhnejad; Gholamreza RAS antisense inhibition
US6812339B1 (en) * 2000-09-08 2004-11-02 Applera Corporation Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
US6900016B1 (en) * 2000-09-08 2005-05-31 Applera Corporation Polymorphisms in known genes associated with inflammatory autoimmune disease, methods of detection and uses thereof

Also Published As

Publication number Publication date
CA2312051A1 (en) 2002-01-13
AU2001276205B2 (en) 2006-02-16
DE60131973D1 (de) 2008-01-31
WO2002006462A2 (en) 2002-01-24
US7316900B2 (en) 2008-01-08
US20040053259A1 (en) 2004-03-18
WO2002006462A3 (en) 2002-10-24
EP1303599B1 (en) 2007-12-19
ES2298243T3 (es) 2008-05-16
JP2004504028A (ja) 2004-02-12
AU7620501A (en) 2002-01-30
DE60131973T2 (de) 2008-12-04
EP1303599A2 (en) 2003-04-23

Similar Documents

Publication Publication Date Title
DK1068311T3 (da) Fremgangsmåder og midler til opnåelse af modificerede fænotyper
SI1546174T1 (sl) Metode in sestavki za rna interferenco
NZ521698A (en) Targeted chromosomal genomic alterations with modified single stranded oligonucleotides
DE69125374D1 (en) Endonukleasen
BR112020026246A2 (pt) composições, sistemas e métodos de amplificação com base em nickase dupla crispr
NZ522406A (en) Single copy genomic hybridization probes and method of generating same
DE60207275D1 (de) Identifizierung von eukaryotischen internal ribosome entry site elementen (ires)
Bestor Cytosine methylation and the unequal developmental potentials of the oocyte and sperm genomes
GB2589246A (en) Methods and systems for guide RNA design and use
Prokhorova et al. Natural nucleoside modifications in guide RNAs can modulate the activity of the CRISPR-Cas9 system in vitro
Adams et al. The effect of 5-azadeoxycytidine on cell growth and DNA methylation
Herdewijn Oligonucleotide synthesis: methods and applications
Zhang et al. Regulatory roles of Alu transcript on gene expression
ATE381616T1 (de) Regulation der upa gen-expression durch methylierte nukleotide
Qin et al. Programmable base editing in zebrafish using a modified CRISPR-Cas9 system
Lau et al. In vitro evolution of coenzyme-independent variants from the glmS ribozyme structural scaffold
Sheng et al. Engineered delta ribozymes can simultaneously knock down the expression of the genes encoding uracil phosphoribosyltransferase and hypoxanthine–xanthine–guanine phosphoribosyltransferase in Toxoplasma gondii
DE69840862D1 (de) Dna fragmente die das biotinsynthasegen enthalten und deren verwendung
Joardar et al. Box C/D RNA-guided 2′-O methylations and the intron of tRNATrp are not essential for the viability of Haloferax volcanii
Young et al. The end groups of T7 mRNA
Čuljković et al. Poly (A) tailing of ancient DNA: a method for reproducible microsatellite genotyping
ATE381615T1 (de) Nukleinsäure-enzym zur spaltung von rna
Kapadia Measurement of Ribozyme Cleavage Reaction Using Toehold Mediated Strand Displacement; Design, Validation and Possible Applications
ATE159048T1 (de) Modifizierung des zellmetabolismus durch extrazellulöse nukleasen
ATE437226T1 (de) Selektiv-abtöten von zellen durch aktivierung der doppelsträngiges rns abhängigen proteinkinase - pkr

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties