ATE375T1 - FLU VIRUS VACCINE AND METHOD OF PRODUCTION. - Google Patents

FLU VIRUS VACCINE AND METHOD OF PRODUCTION.

Info

Publication number
ATE375T1
ATE375T1 AT79102214T AT79102214T ATE375T1 AT E375 T1 ATE375 T1 AT E375T1 AT 79102214 T AT79102214 T AT 79102214T AT 79102214 T AT79102214 T AT 79102214T AT E375 T1 ATE375 T1 AT E375T1
Authority
AT
Austria
Prior art keywords
strain
influenza
virus
vaccine
production
Prior art date
Application number
AT79102214T
Other languages
German (de)
Inventor
Michele Loebmann
Gerard Florent
Original Assignee
Smith Kline - Rit Societe Anonyme Dite:
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline - Rit Societe Anonyme Dite: filed Critical Smith Kline - Rit Societe Anonyme Dite:
Application granted granted Critical
Publication of ATE375T1 publication Critical patent/ATE375T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain. The new strain, which is the CNCM I-062 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/Alaska/5/77 virus strain. The vaccine is prepared by allowing the CNCM I-062 strain to grow in the allantoic cavity of fertile hen's eggs, harvesting and freeze-drying the yielded virus material. The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H3N2) virus strains.
AT79102214T 1978-07-12 1979-07-02 FLU VIRUS VACCINE AND METHOD OF PRODUCTION. ATE375T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/923,846 US4318903A (en) 1978-07-12 1978-07-12 Live influenza virus vaccine and the preparation thereof
EP79102214A EP0007467B1 (en) 1978-07-12 1979-07-02 Anti-influenza vaccine and process for its preparation

Publications (1)

Publication Number Publication Date
ATE375T1 true ATE375T1 (en) 1981-11-15

Family

ID=25449347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102214T ATE375T1 (en) 1978-07-12 1979-07-02 FLU VIRUS VACCINE AND METHOD OF PRODUCTION.

Country Status (5)

Country Link
US (1) US4318903A (en)
EP (1) EP0007467B1 (en)
JP (1) JPS5527178A (en)
AT (1) ATE375T1 (en)
DE (1) DE2961311D1 (en)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278662A (en) * 1979-10-16 1981-07-14 Smith Kline - Rit Attenuated influenza type A virus vaccine
US4554159A (en) * 1981-11-12 1985-11-19 Institute Merieux Vaccine and method of immunizing against herpes simplex virus (types 1 and 2)
US4683137A (en) * 1982-04-16 1987-07-28 Cornell Research Foundation, Inc. Temperature sensitive reassortant viruses and a vaccine against equine influenza
US5866383A (en) * 1982-11-30 1999-02-02 The United States Of America As Represented By The Department Of Health And Human Services In vitro ligation of foreign DNA into large eukaryotic viruses
US4552757A (en) * 1983-12-20 1985-11-12 St. Jude Children's Research Hospital Use in an animal host and precursors for vaccines utilizing avian-human reassortants to combat influenza A virus
US4552758A (en) * 1983-12-20 1985-11-12 St. Jude Children's Research Hospital Human use of avian-human reassortants as vaccines for influenza A virus
IT1198745B (en) * 1983-12-21 1988-12-21 Marcello Giuliani ROTATING CLEANER FOR COTTON AND LANIERA CARDA IN GENERAL
US4783411A (en) * 1984-10-22 1988-11-08 Janis Gabliks Influenza-A virus vaccine from fish cell cultures
NZ224422A (en) * 1987-05-05 1990-11-27 Molecular Eng Ass Composition adapted for intranasal immunisation against viral infection comprising a glycoprotein complexed with a lipid
US5299414A (en) * 1992-07-24 1994-04-05 Ryobi Motor Products Corp. Mulching lawn mower blade and housing assembly
US7468187B2 (en) * 2005-10-18 2008-12-23 Iowa State University Research Foundation, Inc. Canine influenza virus and related compositions and methods of use
EP2411049B1 (en) 2009-03-27 2020-01-15 Academia Sinica Methods and compositions for immunization against virus
WO2010144797A2 (en) 2009-06-12 2010-12-16 Vaccine Technologies, Incorporated Influenza vaccines with enhanced immunogenicity and uses thereof
TWI537385B (en) * 2010-11-04 2016-06-11 中央研究院 Methods for producing virus particles with simplified glycosylation of surface proteins

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4009258A (en) * 1972-09-25 1977-02-22 The Mount Sinai School Of Medicine Of The City University Of New York Influenza vaccine containing a recombinant, antigenically hybridized virus and method of using the same
US3953592A (en) * 1973-09-27 1976-04-27 Recherche Et Industrie Therapeutiques (R.I.T.) Live influenza virus vaccines and preparation thereof
GB1488800A (en) * 1973-11-29 1977-10-12 Wellcome Found Influenza vaccines
US3962423A (en) * 1974-02-04 1976-06-08 Recherche Et Industrie Therapeutiques (R.I.T.) Live influenza type B virus vaccines and preparation thereof
FR2354778A2 (en) * 1976-06-18 1978-01-13 Rit Rech Ind Therapeut LIVE VIRAL INFLUENZA VACCINES AND THEIR PREPARATION METHOD
BE843093A (en) * 1976-06-18 1976-12-20 LIVE INFLUENZA VACCINE

Also Published As

Publication number Publication date
DE2961311D1 (en) 1982-01-14
EP0007467A1 (en) 1980-02-06
US4318903A (en) 1982-03-09
JPS5527178A (en) 1980-02-27
EP0007467B1 (en) 1981-11-11

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee
REN Ceased due to non-payment of the annual fee