ATE371736T1 - Modifizierte steroid-hormon rezeptoren - Google Patents
Modifizierte steroid-hormon rezeptorenInfo
- Publication number
- ATE371736T1 ATE371736T1 AT97949348T AT97949348T ATE371736T1 AT E371736 T1 ATE371736 T1 AT E371736T1 AT 97949348 T AT97949348 T AT 97949348T AT 97949348 T AT97949348 T AT 97949348T AT E371736 T1 ATE371736 T1 AT E371736T1
- Authority
- AT
- Austria
- Prior art keywords
- steroid hormone
- present
- provides
- hormone receptor
- hormone receptors
- Prior art date
Links
- 108020003113 steroid hormone receptors Proteins 0.000 title abstract 5
- 102000005969 steroid hormone receptors Human genes 0.000 title abstract 5
- 238000000034 method Methods 0.000 abstract 3
- 229940123486 Hormone receptor agonist Drugs 0.000 abstract 2
- 102000008300 Mutant Proteins Human genes 0.000 abstract 2
- 108010021466 Mutant Proteins Proteins 0.000 abstract 2
- 239000013612 plasmid Substances 0.000 abstract 2
- 239000003274 steroid hormone receptor blocking agent Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000006274 endogenous ligand Substances 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 239000000698 hormone receptor stimulating agent Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8237—Externally regulated expression systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8237—Externally regulated expression systems
- C12N15/8238—Externally regulated expression systems chemically inducible, e.g. tetracycline
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
- G01N2333/723—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2996496P | 1996-10-29 | 1996-10-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE371736T1 true ATE371736T1 (de) | 2007-09-15 |
Family
ID=21851806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97949348T ATE371736T1 (de) | 1996-10-29 | 1997-10-28 | Modifizierte steroid-hormon rezeptoren |
Country Status (8)
Country | Link |
---|---|
US (3) | US20020147327A1 (de) |
EP (1) | EP0935657B1 (de) |
JP (1) | JP2001504690A (de) |
AT (1) | ATE371736T1 (de) |
AU (1) | AU6908998A (de) |
CA (1) | CA2269642A1 (de) |
DE (1) | DE69738072T2 (de) |
WO (1) | WO1998018925A2 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000031286A1 (en) * | 1998-11-20 | 2000-06-02 | Valentis, Inc. | Adenoviral vector-mediated delivery of modified steroid hormone receptors and related products and methods |
DE19933075C2 (de) * | 1999-07-19 | 2001-11-29 | Deutsches Krebsforsch | Nicht-menschliches Säugetier mit gewebespezifisch verändertem Glukokortikoidrezeptor |
US7329728B1 (en) * | 1999-10-25 | 2008-02-12 | The Scripps Research Institute | Ligand activated transcriptional regulator proteins |
US7011972B2 (en) | 2000-07-18 | 2006-03-14 | The Scripps Research Institute | Fusion polypeptide comprising two ligand binding domains |
NZ523649A (en) * | 2000-07-18 | 2005-02-25 | Novartis Ag | Regulation of gene expression using single-chain, monomeric, ligand dependent polypeptide switches |
WO2002024899A2 (en) * | 2000-09-25 | 2002-03-28 | Valentis, Inc. | Improved system for regulation of transgene expression |
DE60228082D1 (de) | 2001-05-31 | 2008-09-18 | Novartis Ag | Nten und neue liganden und pharmazeutische zusammensetzungen |
US20040086946A1 (en) * | 2002-11-05 | 2004-05-06 | Murphy Andrew J. | Methods of isolation of active compounds and activated targets |
US20070087346A1 (en) * | 2003-10-24 | 2007-04-19 | Gennaro Ciliberto | Orthogonal gene switches |
EP2179044A4 (de) * | 2007-07-06 | 2012-06-06 | Temasek Life Sciences Lab Ltd | Mit einer chemikalie auf lexa-basis induzierbares genexpressionssystem zur verwendung in transgenen tieren |
HUE024479T2 (en) * | 2007-10-08 | 2016-01-28 | Intrexon Corp | Genetically altered dendritic cells and uses for cancer treatment |
MX340972B (es) | 2008-10-08 | 2016-08-02 | Intrexon Corp | Celulas manipuladas por ingenieria que expresan multiples inmunomoduladores, y uso de las mismas. |
WO2010114143A1 (ja) * | 2009-03-30 | 2010-10-07 | 国立大学法人岡山大学 | 特異的プロモーターの活性を上昇させるシステム及び該システムを保持したベクター |
MX362513B (es) * | 2010-03-23 | 2019-01-22 | Intrexon Corp | Vectores que expresan de manera condicional proteinas terapeuticas, celulas hospedadoras que comprenden vectores, y usos de los mismos. |
EP4196493A1 (de) | 2020-08-13 | 2023-06-21 | A2 Biotherapeutics, Inc. | Genfusionen zur kontrolle genetisch modifizierter zellen |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4736866A (en) * | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
US5217867A (en) * | 1988-11-30 | 1993-06-08 | The Salk Institute For Biological Studies | Receptors: their identification, characterization, preparation and use |
AU633045B2 (en) * | 1988-12-23 | 1993-01-21 | Salk Institute For Biological Studies, The | Receptor transcription-repression activity compositions and methods |
CA2057049A1 (en) * | 1989-05-26 | 1990-11-27 | Ronald M. Evans | Dominant negative members of the steroid/thyroid superfamily of receptors |
US5215916A (en) * | 1991-06-19 | 1993-06-01 | The United States Of America As Represented By The Department Of Health & Human Services | Super glucocorticoid receptors: receptors with increased affinity and specificity for glucocorticoid steriods |
US5298422A (en) * | 1991-11-06 | 1994-03-29 | Baylor College Of Medicine | Myogenic vector systems |
AU685054C (en) * | 1992-05-14 | 2003-02-27 | Baylor College Of Medicine | Mutated steroid hormone receptors, methods for their use and molecular switch for gene therapy |
US5364791A (en) * | 1992-05-14 | 1994-11-15 | Elisabetta Vegeto | Progesterone receptor having C. terminal hormone binding domain truncations |
US6416998B1 (en) * | 1992-09-02 | 2002-07-09 | Baylor College Of Medicine | Plasmid encoding a modified steroid hormone |
-
1997
- 1997-10-28 AT AT97949348T patent/ATE371736T1/de active
- 1997-10-28 JP JP52072398A patent/JP2001504690A/ja active Pending
- 1997-10-28 WO PCT/US1997/019607 patent/WO1998018925A2/en active IP Right Grant
- 1997-10-28 CA CA002269642A patent/CA2269642A1/en not_active Abandoned
- 1997-10-28 EP EP97949348A patent/EP0935657B1/de not_active Expired - Lifetime
- 1997-10-28 AU AU69089/98A patent/AU6908998A/en not_active Abandoned
- 1997-10-28 DE DE69738072T patent/DE69738072T2/de not_active Expired - Lifetime
-
2001
- 2001-07-25 US US09/916,145 patent/US20020147327A1/en not_active Abandoned
-
2002
- 2002-04-16 US US10/124,741 patent/US20030109683A1/en not_active Abandoned
- 2002-04-16 US US10/124,739 patent/US20020182698A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1998018925A3 (en) | 1998-10-15 |
DE69738072T2 (de) | 2008-05-21 |
US20020147327A1 (en) | 2002-10-10 |
DE69738072D1 (de) | 2007-10-11 |
CA2269642A1 (en) | 1998-05-07 |
US20030109683A1 (en) | 2003-06-12 |
EP0935657B1 (de) | 2007-08-29 |
AU6908998A (en) | 1998-05-22 |
EP0935657A2 (de) | 1999-08-18 |
WO1998018925A2 (en) | 1998-05-07 |
US20020182698A1 (en) | 2002-12-05 |
JP2001504690A (ja) | 2001-04-10 |
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