ATE36166T1 - Antimikrobische disulfide pro-arzneimittel. - Google Patents
Antimikrobische disulfide pro-arzneimittel.Info
- Publication number
- ATE36166T1 ATE36166T1 AT83303060T AT83303060T ATE36166T1 AT E36166 T1 ATE36166 T1 AT E36166T1 AT 83303060 T AT83303060 T AT 83303060T AT 83303060 T AT83303060 T AT 83303060T AT E36166 T1 ATE36166 T1 AT E36166T1
- Authority
- AT
- Austria
- Prior art keywords
- antimicrobic
- disulfid
- pro
- drug
- antimicrobial
- Prior art date
Links
- 229940002612 prodrug Drugs 0.000 title abstract 2
- 239000000651 prodrug Substances 0.000 title abstract 2
- 230000003377 anti-microbal effect Effects 0.000 title 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 2
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003412 L-alanyl group Chemical group [H]N([H])[C@@](C([H])([H])[H])(C(=O)[*])[H] 0.000 abstract 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/29—Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/386,365 US4427582A (en) | 1982-06-08 | 1982-06-08 | Antimicrobial disulfide prodrugs |
| EP83303060A EP0128249B1 (de) | 1982-06-08 | 1983-05-27 | Antimikrobische disulfide Pro-Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE36166T1 true ATE36166T1 (de) | 1988-08-15 |
Family
ID=23525295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83303060T ATE36166T1 (de) | 1982-06-08 | 1983-05-27 | Antimikrobische disulfide pro-arzneimittel. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4427582A (de) |
| EP (1) | EP0128249B1 (de) |
| JP (1) | JPS595150A (de) |
| AT (1) | ATE36166T1 (de) |
| AU (1) | AU562703B2 (de) |
| DE (1) | DE3377578D1 (de) |
| DK (1) | DK261283A (de) |
| ES (1) | ES8504692A1 (de) |
| GR (1) | GR77483B (de) |
| IE (1) | IE55428B1 (de) |
| PT (1) | PT76786B (de) |
| ZA (1) | ZA833350B (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU563196B2 (en) * | 1982-05-18 | 1987-07-02 | Smithkline Beckman Corporation | Peptide prodrug transport system |
| AU605214B2 (en) * | 1986-10-24 | 1991-01-10 | Fresenius Kabi Ab | N,n'-bis-amino acid-l-cystine-peptide-containing amino acid preparations for oral and parenteral administration |
| US6423519B1 (en) * | 1998-07-15 | 2002-07-23 | Gpc Biotech Inc. | Compositions and methods for inhibiting fungal growth |
| US20070219250A1 (en) * | 2003-11-28 | 2007-09-20 | Romi Singh | Pharmaceutical Compositions of Nateglinide |
| FR2976944A1 (fr) * | 2011-06-21 | 2012-12-28 | Centre Nat Rech Scient | Prodrogues peptidiques |
| GB2529356B (en) * | 2013-04-28 | 2020-12-23 | Genequantum Healthcare Co Ltd | Novel linkers, coupling intermediates, conjugates, preparation method and application thereof |
| CN117042806A (zh) | 2021-03-08 | 2023-11-10 | 启德医药科技（苏州）有限公司 | 抗体-免疫激动剂缀合物及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE448631B (sv) | 1978-04-28 | 1987-03-09 | Toyo Jozo Kk | Disulfidforening av en berare med s-s-utbytesreaktivitet |
| US4258193A (en) | 1978-07-13 | 1981-03-24 | Toyo Jozo Kabushiki Kaisha | Disulfide derivatives having S--S exchange reactivity |
| US4284624A (en) | 1980-05-02 | 1981-08-18 | E. R. Squibb & Sons, Inc. | Mixed disulfides |
-
1982
- 1982-06-08 US US06/386,365 patent/US4427582A/en not_active Expired - Fee Related
-
1983
- 1983-05-10 ZA ZA833350A patent/ZA833350B/xx unknown
- 1983-05-11 AU AU14462/83A patent/AU562703B2/en not_active Ceased
- 1983-05-27 EP EP83303060A patent/EP0128249B1/de not_active Expired
- 1983-05-27 AT AT83303060T patent/ATE36166T1/de not_active IP Right Cessation
- 1983-05-27 DE DE8383303060T patent/DE3377578D1/de not_active Expired
- 1983-05-31 PT PT76786A patent/PT76786B/pt unknown
- 1983-06-02 GR GR71543A patent/GR77483B/el unknown
- 1983-06-07 ES ES523048A patent/ES8504692A1/es not_active Expired
- 1983-06-07 IE IE1330/83A patent/IE55428B1/en unknown
- 1983-06-07 JP JP58102533A patent/JPS595150A/ja active Pending
- 1983-06-08 DK DK261283A patent/DK261283A/da unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US4427582A (en) | 1984-01-24 |
| IE55428B1 (en) | 1990-09-12 |
| JPS595150A (ja) | 1984-01-12 |
| ES523048A0 (es) | 1985-04-16 |
| DK261283A (da) | 1983-12-09 |
| PT76786A (en) | 1983-06-01 |
| AU1446283A (en) | 1983-12-15 |
| EP0128249A2 (de) | 1984-12-19 |
| DE3377578D1 (en) | 1988-09-08 |
| DK261283D0 (da) | 1983-06-08 |
| AU562703B2 (en) | 1987-06-18 |
| GR77483B (de) | 1984-09-24 |
| EP0128249A3 (en) | 1985-10-09 |
| EP0128249B1 (de) | 1988-08-03 |
| IE831330L (en) | 1983-12-08 |
| PT76786B (en) | 1985-12-13 |
| ZA833350B (en) | 1984-04-25 |
| ES8504692A1 (es) | 1985-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |