ATE354087T1 - Die verwendung der familie der rev-erb receptoren im screening - Google Patents

Die verwendung der familie der rev-erb receptoren im screening

Info

Publication number
ATE354087T1
ATE354087T1 AT99928010T AT99928010T ATE354087T1 AT E354087 T1 ATE354087 T1 AT E354087T1 AT 99928010 T AT99928010 T AT 99928010T AT 99928010 T AT99928010 T AT 99928010T AT E354087 T1 ATE354087 T1 AT E354087T1
Authority
AT
Austria
Prior art keywords
rev
substances
screening
iii
useful
Prior art date
Application number
AT99928010T
Other languages
English (en)
Inventor
Eric Raspe
Yves Bonhomme
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE354087T1 publication Critical patent/ATE354087T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders
    • G01N2800/044Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
AT99928010T 1998-06-25 1999-06-21 Die verwendung der familie der rev-erb receptoren im screening ATE354087T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9808093A FR2780512B1 (fr) 1998-06-25 1998-06-25 Utilisation de recepteurs de la famille rev-erb pour le criblage de substances utiles dans le traitement des dysfonctionnements du metabolisme lipidique
PCT/EP1999/004286 WO1999067637A1 (en) 1998-06-25 1999-06-21 Use of rev-erb family of receptors in screening

Publications (1)

Publication Number Publication Date
ATE354087T1 true ATE354087T1 (de) 2007-03-15

Family

ID=9527876

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99928010T ATE354087T1 (de) 1998-06-25 1999-06-21 Die verwendung der familie der rev-erb receptoren im screening

Country Status (11)

Country Link
US (1) US7691628B1 (de)
EP (1) EP1090292B1 (de)
JP (1) JP2003524755A (de)
AT (1) ATE354087T1 (de)
AU (1) AU4515599A (de)
CA (1) CA2336009C (de)
ES (1) ES2283118T3 (de)
FR (1) FR2780512B1 (de)
NZ (1) NZ507935A (de)
TW (1) TW577984B (de)
WO (1) WO1999067637A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL151355A0 (en) * 2000-03-03 2003-04-10 Smithkline Beecham Biolog Vaccine for the treatment of artherosclerosis
US6579686B2 (en) 2000-03-23 2003-06-17 Smithkline Beecham Corporation Constitutive androstane receptor
FR2834996B1 (fr) * 2002-01-18 2004-12-03 Genfit S A Methode d'identification de substances capables de moduler la differenciation adipocytaire
JP2005516605A (ja) * 2002-02-01 2005-06-09 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 心血管疾患を処置するための方法および組成物
AU2003227071A1 (en) * 2002-03-14 2003-09-22 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung Cg8327, cg10823, cg18418, cg15862, cg3768, cg11447 and cg16750 homologous proteins involved in the regulation of energy homeostasis
AU2003274715A1 (en) * 2002-06-10 2003-12-22 Develogen Aktiengesellschaft Fur Entwicklungsbiologische Forschung L(2)44 dea, wunen-2, grapes, cg2221, cg1172, rutabaga, cg11940, facl involved in the regulation of energy homeostasis
JPWO2004053124A1 (ja) * 2002-12-06 2006-04-13 塩野義製薬株式会社 糖尿病治療剤又は予防剤のスクリーニング方法
EP1572227B1 (de) * 2002-12-16 2012-02-15 DeveloGen Aktiengesellschaft Pik4cb involviert in der regulierung des energiestoffwechsels
AU2012314501B2 (en) 2011-09-27 2017-02-16 Genfit Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2222562A1 (en) * 1995-06-07 1996-12-19 Jeffrey N. Miner Method for screening for receptor agonists and antagonists
US5906920A (en) * 1995-08-29 1999-05-25 The Salk Institute For Biological Studies Methods for the detection of ligands for retinoid X receptors
DK0873295T3 (da) * 1995-10-06 2003-07-14 Ligand Pharm Inc Dimer-selektive RXR-modulatorer og fremgangsmåder til deres anvendelse
CA2266543C (en) * 1996-09-24 2003-12-09 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
WO1998052968A1 (en) * 1997-05-21 1998-11-26 The Salk Institute For Biological Studies Method for identification of modified receptor ligands and methods of use therefor

Also Published As

Publication number Publication date
ES2283118T3 (es) 2007-10-16
US7691628B1 (en) 2010-04-06
EP1090292A1 (de) 2001-04-11
NZ507935A (en) 2003-10-31
EP1090292B1 (de) 2007-02-14
WO1999067637A1 (en) 1999-12-29
AU4515599A (en) 2000-01-10
FR2780512B1 (fr) 2003-10-17
JP2003524755A (ja) 2003-08-19
TW577984B (en) 2004-03-01
CA2336009A1 (en) 1999-12-29
CA2336009C (en) 2009-02-10
FR2780512A1 (fr) 1999-12-31

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