ATE353649T1 - Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivität - Google Patents
Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivitätInfo
- Publication number
- ATE353649T1 ATE353649T1 AT04726520T AT04726520T ATE353649T1 AT E353649 T1 ATE353649 T1 AT E353649T1 AT 04726520 T AT04726520 T AT 04726520T AT 04726520 T AT04726520 T AT 04726520T AT E353649 T1 ATE353649 T1 AT E353649T1
- Authority
- AT
- Austria
- Prior art keywords
- anxiology
- antidepressant
- imidazole
- phenyl
- substituted
- Prior art date
Links
- GBANLFWFVPIRMO-UHFFFAOYSA-N 4-(1h-imidazol-2-yl)-4-phenylpiperidine Chemical class C1CNCCC1(C=1C=CC=CC=1)C1=NC=CN1 GBANLFWFVPIRMO-UHFFFAOYSA-N 0.000 title 1
- 229940127450 Opioid Agonists Drugs 0.000 title 1
- 230000001430 anti-depressive effect Effects 0.000 title 1
- 239000000935 antidepressant agent Substances 0.000 title 1
- 229940005513 antidepressants Drugs 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP0303879 | 2003-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE353649T1 true ATE353649T1 (de) | 2007-03-15 |
Family
ID=33154992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04726520T ATE353649T1 (de) | 2003-04-11 | 2004-04-08 | Substituierte 4-phenyl-4-(1h-imidazol-2-yl)- piperidinderivate und deren verwendung als selektive nicht-peptidische delta-opioid- agonisten mit antidepressiver und angstlösender aktivität |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20060287345A1 (https=) |
| EP (1) | EP1615644B1 (https=) |
| JP (1) | JP2006522775A (https=) |
| AR (1) | AR044010A1 (https=) |
| AT (1) | ATE353649T1 (https=) |
| AU (1) | AU2004228960A1 (https=) |
| CA (1) | CA2521186A1 (https=) |
| CL (1) | CL2004000754A1 (https=) |
| DE (1) | DE602004004771T2 (https=) |
| ES (1) | ES2282858T3 (https=) |
| TW (1) | TW200509913A (https=) |
| WO (1) | WO2004089372A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1390848B1 (it) | 2008-07-31 | 2011-10-19 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| EP2149370A1 (en) | 2008-07-31 | 2010-02-03 | Neuroscienze Pharmaness S.C. A R.L. | Diazabicyclic compounds and microemulsions thereof |
| JP2011030565A (ja) * | 2009-07-06 | 2011-02-17 | Yokohama City Univ | 社会的隔離モデル動物 |
| IT1396951B1 (it) | 2009-12-18 | 2012-12-20 | Neuroscienze Pharmaness S C A R L | Composti farmaceutici |
| CA2911231C (en) * | 2013-05-24 | 2021-12-07 | Alkermes Pharma Ireland Limited | Morphan and morphinan analogues, and methods of use |
| CN113292559B (zh) | 2015-03-17 | 2024-04-02 | 日本化学药品株式会社 | 吗啡喃衍生物 |
| US20210371422A1 (en) | 2016-08-09 | 2021-12-02 | Nippon Chemiphar Co., Ltd. | Morphinan derivative |
| US11633392B2 (en) | 2016-09-16 | 2023-04-25 | Nippon Chemiphar Co., Ltd. | Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease |
| MA52482B1 (fr) | 2018-05-01 | 2024-12-31 | Merck Sharp & Dohme Llc | Dérivés de spiropipéridine en tant que modulateurs allostériques des récepteurs nicotiniques de l'acétylcholine |
| AU2020385852A1 (en) | 2019-11-22 | 2022-06-02 | Nippon Chemiphar Co., Ltd. | Pyrazolomorphinan derivative |
| CA3211977A1 (en) | 2021-02-26 | 2022-09-01 | Tokyo University Of Science Foundation | Pharmaceutical composition for treatment or prevention of stress-related disorders |
| US20220305020A1 (en) * | 2021-03-26 | 2022-09-29 | Ingenious Ingredients, LP | The use of paraxanthine to reduce exercise-induced mental fatigue |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5354863A (en) * | 1992-01-21 | 1994-10-11 | G. D. Searle & Co. | Opioid agonist compounds |
| DE19805370A1 (de) * | 1997-03-14 | 1998-09-17 | Gruenenthal Gmbh | Substituierte Aminoverbindungen und ihre Verwendung als analgetisch wirksame Substanzen |
| HN1999000149A (es) * | 1998-09-09 | 2000-01-12 | Pfizer Prod Inc | Derivados de 4,4-biarilpiperidina |
| EP1038872A1 (en) * | 1999-02-22 | 2000-09-27 | Pfizer Products Inc. | 4-Phenyl-4-heteroarylpiperdine derivatives as opioid receptor ligands |
| DE19939044A1 (de) * | 1999-08-18 | 2001-03-15 | Gruenenthal Gmbh | Verwendung von Morphinanderivaten als Arzneimittel |
| SE0101767D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | Novel compounds |
| BR0213325A (pt) * | 2001-10-15 | 2004-10-13 | Janssen Pharmaceutica Nv | Derivados de 4-fenil-4-[1h-imidazol-2-il]-piperidina substituìda para a redução de dano isquêmico |
| EA006507B1 (ru) * | 2001-10-15 | 2005-12-29 | Янссен Фармацевтика Н.В. | Новые замещенные 4-фенил-4-[1h-имидазол-2-ил] пиперидиновые производные и их применение в качестве селективных непептидных агонистов дельта-опиоидов |
-
2004
- 2004-04-07 CL CL200400754A patent/CL2004000754A1/es unknown
- 2004-04-07 AR ARP040101193A patent/AR044010A1/es not_active Application Discontinuation
- 2004-04-08 DE DE602004004771T patent/DE602004004771T2/de not_active Expired - Fee Related
- 2004-04-08 ES ES04726520T patent/ES2282858T3/es not_active Expired - Lifetime
- 2004-04-08 EP EP04726520A patent/EP1615644B1/en not_active Expired - Lifetime
- 2004-04-08 US US10/552,527 patent/US20060287345A1/en not_active Abandoned
- 2004-04-08 AU AU2004228960A patent/AU2004228960A1/en not_active Abandoned
- 2004-04-08 CA CA002521186A patent/CA2521186A1/en not_active Abandoned
- 2004-04-08 JP JP2006505540A patent/JP2006522775A/ja not_active Withdrawn
- 2004-04-08 WO PCT/EP2004/050492 patent/WO2004089372A1/en not_active Ceased
- 2004-04-08 AT AT04726520T patent/ATE353649T1/de not_active IP Right Cessation
- 2004-04-09 TW TW093109827A patent/TW200509913A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200509913A (en) | 2005-03-16 |
| AR044010A1 (es) | 2005-08-24 |
| ES2282858T3 (es) | 2007-10-16 |
| DE602004004771D1 (de) | 2007-03-29 |
| EP1615644B1 (en) | 2007-02-14 |
| DE602004004771T2 (de) | 2007-12-06 |
| JP2006522775A (ja) | 2006-10-05 |
| EP1615644A1 (en) | 2006-01-18 |
| AU2004228960A1 (en) | 2004-10-21 |
| US20060287345A1 (en) | 2006-12-21 |
| CL2004000754A1 (es) | 2005-02-25 |
| WO2004089372A1 (en) | 2004-10-21 |
| CA2521186A1 (en) | 2004-10-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |