ATE351914T1 - Verfahren zur erzeugung von schnell mutierender hefe - Google Patents

Verfahren zur erzeugung von schnell mutierender hefe

Info

Publication number
ATE351914T1
ATE351914T1 AT01911013T AT01911013T ATE351914T1 AT E351914 T1 ATE351914 T1 AT E351914T1 AT 01911013 T AT01911013 T AT 01911013T AT 01911013 T AT01911013 T AT 01911013T AT E351914 T1 ATE351914 T1 AT E351914T1
Authority
AT
Austria
Prior art keywords
repair system
mismatch repair
yeast
producing rapidly
rapidly mutating
Prior art date
Application number
AT01911013T
Other languages
English (en)
Inventor
Nicholas C Nicolaides
Philip M Sass
Luigi Grasso
Bert Vogelstein
Kenneth W Kinzler
Original Assignee
Univ Johns Hopkins
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Morphotek Inc filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE351914T1 publication Critical patent/ATE351914T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AT01911013T 2000-02-23 2001-02-21 Verfahren zur erzeugung von schnell mutierender hefe ATE351914T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18433600P 2000-02-23 2000-02-23

Publications (1)

Publication Number Publication Date
ATE351914T1 true ATE351914T1 (de) 2007-02-15

Family

ID=22676473

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01911013T ATE351914T1 (de) 2000-02-23 2001-02-21 Verfahren zur erzeugung von schnell mutierender hefe

Country Status (8)

Country Link
US (4) US6656736B2 (de)
EP (1) EP1259628B1 (de)
AT (1) ATE351914T1 (de)
AU (1) AU2001238558A1 (de)
CA (1) CA2399191C (de)
DE (1) DE60126065T2 (de)
DK (1) DK1259628T5 (de)
WO (1) WO2001062945A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2398094C (en) * 2000-02-11 2013-01-08 The Johns Hopkins University Methods for generating hypermutable microbes
DK1259628T5 (da) * 2000-02-23 2018-06-14 Univ Johns Hopkins Fremgangsmåde til dannelse af hypermutabel gær
WO2001088192A2 (en) * 2000-05-12 2001-11-22 The Johns Hopkins University A method for generating hypermutable organisms
IL154099A0 (en) * 2000-07-27 2003-07-31 Univ Delaware A method and kit for enhancing oligonucleotide-mediated gene alteration
CA2473741C (en) * 2002-01-18 2015-12-22 Morphotek, Inc. A method for generating engineered cells for locus specific gene regulation and analysis
US20030165468A1 (en) * 2002-02-21 2003-09-04 Luigi Grasso Regulated vectors for controlling DNA hypermutability in eukaryotic cells
AU2003248361B2 (en) * 2002-02-21 2008-07-03 Morphotek, Inc. Methods of making hypermutable cells using PMSR homologs
AU2003233719A1 (en) 2002-06-06 2003-12-22 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Modifying the dna recombination potential in eukaryotes
EP2115127A4 (de) * 2007-01-17 2010-04-07 Life Technologies Corp Verfahren und zusammensetzungen zur verbesserung der zellgesundheit in kulturen
CA2678451A1 (en) * 2007-02-20 2008-08-28 Robert A. Horlick Somatic hypermutation systems
US20150307876A1 (en) * 2012-02-10 2015-10-29 Regents Of The University Of Minnesota Dna assimilation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
US5587290A (en) * 1995-06-26 1996-12-24 The Regents Of The University Of California Stress tolerant yeast mutants
US5843757A (en) 1995-08-24 1998-12-01 The Johns Hopkins University Human JTV1 gene overlaps PMS2 gene
US5907079A (en) 1996-01-18 1999-05-25 Amgen Canada Inc. MSH2 disrupted mice develop lymphomas
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
DK1259628T5 (da) * 2000-02-23 2018-06-14 Univ Johns Hopkins Fremgangsmåde til dannelse af hypermutabel gær

Also Published As

Publication number Publication date
DE60126065D1 (de) 2007-03-08
EP1259628A1 (de) 2002-11-27
CA2399191A1 (en) 2001-08-30
US20020123149A1 (en) 2002-09-05
US6656736B2 (en) 2003-12-02
AU2001238558A1 (en) 2001-09-03
EP1259628B1 (de) 2007-01-17
DK1259628T3 (da) 2007-05-21
US20080176329A1 (en) 2008-07-24
DK1259628T5 (da) 2018-06-14
DE60126065T2 (de) 2007-08-30
US6921666B2 (en) 2005-07-26
US20050272140A1 (en) 2005-12-08
WO2001062945A1 (en) 2001-08-30
US20040092021A1 (en) 2004-05-13
CA2399191C (en) 2010-12-14
US7759121B2 (en) 2010-07-20
US7514216B2 (en) 2009-04-07

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