ATE344089T1 - 2-amino-6-(2,4,5-substituierte-phenyl)-pyridine zur verwendung als stickoxid-synthase-hemmer - Google Patents

2-amino-6-(2,4,5-substituierte-phenyl)-pyridine zur verwendung als stickoxid-synthase-hemmer

Info

Publication number
ATE344089T1
ATE344089T1 AT02775016T AT02775016T ATE344089T1 AT E344089 T1 ATE344089 T1 AT E344089T1 AT 02775016 T AT02775016 T AT 02775016T AT 02775016 T AT02775016 T AT 02775016T AT E344089 T1 ATE344089 T1 AT E344089T1
Authority
AT
Austria
Prior art keywords
pyridines
phenyl
amino
substituted
nitrogen oxide
Prior art date
Application number
AT02775016T
Other languages
English (en)
Inventor
John A Lowe Iii
Robert A Volkmann
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE344089T1 publication Critical patent/ATE344089T1/de

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
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    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
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    • A61P27/02Ophthalmic agents
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
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  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
AT02775016T 2001-10-10 2002-09-24 2-amino-6-(2,4,5-substituierte-phenyl)-pyridine zur verwendung als stickoxid-synthase-hemmer ATE344089T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US32825301P 2001-10-10 2001-10-10

Publications (1)

Publication Number Publication Date
ATE344089T1 true ATE344089T1 (de) 2006-11-15

Family

ID=23280189

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02775016T ATE344089T1 (de) 2001-10-10 2002-09-24 2-amino-6-(2,4,5-substituierte-phenyl)-pyridine zur verwendung als stickoxid-synthase-hemmer

Country Status (36)

Country Link
EP (1) EP1434624B1 (de)
JP (1) JP2005506337A (de)
KR (1) KR20040053157A (de)
CN (1) CN1568207A (de)
AP (1) AP2004003003A0 (de)
AR (1) AR036763A1 (de)
AT (1) ATE344089T1 (de)
BG (1) BG108669A (de)
BR (1) BR0213193A (de)
CA (1) CA2463364A1 (de)
CZ (1) CZ2004450A3 (de)
DE (1) DE60215837T2 (de)
DO (1) DOP2002000467A (de)
EA (1) EA007074B1 (de)
EC (1) ECSP045055A (de)
EE (1) EE200400085A (de)
ES (1) ES2275917T3 (de)
GT (1) GT200200206A (de)
HN (1) HN2002000289A (de)
HR (1) HRP20040260A2 (de)
HU (1) HUP0401678A3 (de)
IL (1) IL161089A0 (de)
IS (1) IS7171A (de)
MA (1) MA27074A1 (de)
MX (1) MXPA04002313A (de)
NO (1) NO20041411L (de)
NZ (1) NZ531591A (de)
OA (1) OA12664A (de)
PA (1) PA8556101A1 (de)
PE (1) PE20030478A1 (de)
PL (1) PL369454A1 (de)
SK (1) SK1642004A3 (de)
TN (1) TNSN04057A1 (de)
UY (1) UY27476A1 (de)
WO (1) WO2003030993A1 (de)
ZA (1) ZA200401747B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232739A1 (en) * 2001-08-15 2003-12-18 Pfizer Inc. Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist
US20080070952A1 (en) * 2005-02-21 2008-03-20 Proximagen Ltd., Inhibition or Treatment of Dyskinesia
WO2012084711A1 (en) * 2010-12-24 2012-06-28 Msd Oss B.V. N-substituted azetidine derivatives
RU2637503C1 (ru) * 2016-12-30 2017-12-05 Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский государственный университет" (ТГУ, НИ ТГУ) Способ получения n2-метилдезоксигуанозина

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0891332T3 (da) * 1996-03-29 2004-07-05 Pfizer 6-phenylpyridyl-2-aminderivater
JP3505189B2 (ja) * 1997-02-10 2004-03-08 ファイザー・プロダクツ・インク 2−アミノ−6−(2−置換−4−フェノキシ)−置換ピリジン
EE200100611A (et) * 1999-05-21 2003-02-17 Pfizer Products Inc. NOS inhibiitorite uued farmatseutilised kombinatsioonid

Also Published As

Publication number Publication date
EA007074B1 (ru) 2006-06-30
AP2004003003A0 (en) 2004-03-31
UY27476A1 (es) 2003-05-30
DE60215837T2 (de) 2007-05-16
EP1434624B1 (de) 2006-11-02
NO20041411L (no) 2004-04-02
AR036763A1 (es) 2004-09-29
ZA200401747B (en) 2005-03-03
MA27074A1 (fr) 2004-12-20
DE60215837D1 (de) 2006-12-14
BR0213193A (pt) 2004-08-31
OA12664A (en) 2006-06-19
BG108669A (en) 2005-03-31
HUP0401678A3 (en) 2007-05-02
HN2002000289A (es) 2002-12-03
EA200400321A1 (ru) 2004-08-26
MXPA04002313A (es) 2005-04-08
WO2003030993A1 (en) 2003-04-17
PA8556101A1 (es) 2003-07-28
EE200400085A (et) 2004-08-16
HRP20040260A2 (en) 2004-12-31
PE20030478A1 (es) 2003-06-06
EP1434624A1 (de) 2004-07-07
ECSP045055A (es) 2004-05-28
PL369454A1 (en) 2005-04-18
CZ2004450A3 (cs) 2005-03-16
SK1642004A3 (sk) 2005-04-01
CA2463364A1 (en) 2003-04-17
KR20040053157A (ko) 2004-06-23
ES2275917T3 (es) 2007-06-16
CN1568207A (zh) 2005-01-19
IL161089A0 (en) 2004-08-31
TNSN04057A1 (fr) 2006-06-01
DOP2002000467A (es) 2003-04-15
JP2005506337A (ja) 2005-03-03
GT200200206A (es) 2003-05-23
IS7171A (is) 2004-03-04
NZ531591A (en) 2006-04-28
HUP0401678A2 (hu) 2004-12-28

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