ATE335732T1 - 4-imidazol-1-ylmethylpyrimidinderivate als liganden für gabaa-rezeptoren - Google Patents
4-imidazol-1-ylmethylpyrimidinderivate als liganden für gabaa-rezeptorenInfo
- Publication number
- ATE335732T1 ATE335732T1 AT03810562T AT03810562T ATE335732T1 AT E335732 T1 ATE335732 T1 AT E335732T1 AT 03810562 T AT03810562 T AT 03810562T AT 03810562 T AT03810562 T AT 03810562T AT E335732 T1 ATE335732 T1 AT E335732T1
- Authority
- AT
- Austria
- Prior art keywords
- sub
- receptors
- ligands
- gaba
- cns
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 3
- 102000027484 GABAA receptors Human genes 0.000 title 1
- 108091008681 GABAA receptors Proteins 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 4
- 229960003692 gamma aminobutyric acid Drugs 0.000 abstract 3
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 abstract 3
- 241001465754 Metazoa Species 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- MIQCQUJDYOHTOK-UHFFFAOYSA-N 4-(imidazol-1-ylmethyl)pyrimidine Chemical compound C1=CN=CN1CC1=CC=NC=N1 MIQCQUJDYOHTOK-UHFFFAOYSA-N 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42494502P | 2002-11-08 | 2002-11-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE335732T1 true ATE335732T1 (de) | 2006-09-15 |
Family
ID=32312901
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03810562T ATE335732T1 (de) | 2002-11-08 | 2003-11-04 | 4-imidazol-1-ylmethylpyrimidinderivate als liganden für gabaa-rezeptoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6951864B2 (enExample) |
| EP (1) | EP1560822B1 (enExample) |
| JP (1) | JP2006508102A (enExample) |
| AT (1) | ATE335732T1 (enExample) |
| AU (1) | AU2003276514A1 (enExample) |
| CA (1) | CA2495708A1 (enExample) |
| DE (1) | DE60307499T2 (enExample) |
| ES (1) | ES2268488T3 (enExample) |
| WO (1) | WO2004041808A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100579579C (zh) | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
| US7351826B2 (en) | 2003-02-19 | 2008-04-01 | Neurogen Corporation | Aryl acid pyrimidinyl methyl amides, pyridazinyl methyl amides and related compounds |
| EP1619948A4 (en) * | 2003-05-05 | 2007-02-14 | Neurogen Corp | SUBSTITUTED IMIDAZOLOPYRAZINE AND TRIAZOLOPYRAZINE DERIVATIVES: GABAA RECEPTOR LIGANDS |
| EP1648899B1 (en) | 2003-07-25 | 2007-01-03 | Neurogen Corporation | Imidazo-pyrimidines and triazolo-pyrimidines: benzodiazepine receptor ligands |
| US7576221B2 (en) | 2004-06-18 | 2009-08-18 | Novartis Vaccines And Diagnostics, Inc. | Substituted imidazole derivatives |
| JP2010515687A (ja) | 2007-01-05 | 2010-05-13 | ノバルティス アーゲー | キネシンスピンドルタンパク質阻害剤（ｅｇ−５）としてのイミダゾール誘導体 |
| US20150374705A1 (en) | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PA8535601A1 (es) * | 2000-12-21 | 2002-11-28 | Pfizer | Derivados benzimidazol y piridilimidazol como ligandos para gabaa |
| JP2004531499A (ja) * | 2001-03-23 | 2004-10-14 | メルク シャープ エンド ドーム リミテッド | Ｇａｂａ受容体用リガンドとしてのイミダゾ−ピリミジン誘導体 |
| CN100579579C (zh) * | 2002-10-01 | 2010-01-13 | 诺华疫苗和诊断公司 | 抗癌及抗感染性疾病组合物及其使用方法 |
-
2003
- 2003-11-04 AU AU2003276514A patent/AU2003276514A1/en not_active Abandoned
- 2003-11-04 WO PCT/IB2003/004978 patent/WO2004041808A1/en not_active Ceased
- 2003-11-04 JP JP2004549490A patent/JP2006508102A/ja active Pending
- 2003-11-04 EP EP03810562A patent/EP1560822B1/en not_active Expired - Lifetime
- 2003-11-04 CA CA002495708A patent/CA2495708A1/en not_active Abandoned
- 2003-11-04 AT AT03810562T patent/ATE335732T1/de not_active IP Right Cessation
- 2003-11-04 DE DE60307499T patent/DE60307499T2/de not_active Expired - Fee Related
- 2003-11-04 ES ES03810562T patent/ES2268488T3/es not_active Expired - Lifetime
- 2003-11-06 US US10/702,629 patent/US6951864B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60307499T2 (de) | 2007-02-01 |
| AU2003276514A1 (en) | 2004-06-07 |
| ES2268488T3 (es) | 2007-03-16 |
| JP2006508102A (ja) | 2006-03-09 |
| EP1560822A1 (en) | 2005-08-10 |
| US6951864B2 (en) | 2005-10-04 |
| US20040102457A1 (en) | 2004-05-27 |
| DE60307499D1 (de) | 2006-09-21 |
| EP1560822B1 (en) | 2006-08-09 |
| CA2495708A1 (en) | 2004-05-21 |
| WO2004041808A1 (en) | 2004-05-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1560822 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |