ATE334671T1 - Wortmanninanaloge und verfahren zu deren verwendung - Google Patents
Wortmanninanaloge und verfahren zu deren verwendungInfo
- Publication number
- ATE334671T1 ATE334671T1 AT02766286T AT02766286T ATE334671T1 AT E334671 T1 ATE334671 T1 AT E334671T1 AT 02766286 T AT02766286 T AT 02766286T AT 02766286 T AT02766286 T AT 02766286T AT E334671 T1 ATE334671 T1 AT E334671T1
- Authority
- AT
- Austria
- Prior art keywords
- analogs
- wordman
- inhibiting
- mammals
- subject
- Prior art date
Links
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 abstract 1
- 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000005740 tumor formation Effects 0.000 abstract 1
- QDLHCMPXEPAAMD-QAIWCSMKSA-N wortmannin Chemical class C1([C@]2(C)C3=C(C4=O)OC=C3C(=O)O[C@@H]2COC)=C4[C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O QDLHCMPXEPAAMD-QAIWCSMKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Pyrane Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Distillation Of Fermentation Liquor, Processing Of Alcohols, Vinegar And Beer (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32214301P | 2001-09-14 | 2001-09-14 | |
| US32213901P | 2001-09-14 | 2001-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE334671T1 true ATE334671T1 (de) | 2006-08-15 |
Family
ID=26983283
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02766286T ATE334671T1 (de) | 2001-09-14 | 2002-09-16 | Wortmanninanaloge und verfahren zu deren verwendung |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1435941B8 (OSRAM) |
| JP (1) | JP4540986B2 (OSRAM) |
| AT (1) | ATE334671T1 (OSRAM) |
| AU (1) | AU2002330029B2 (OSRAM) |
| CA (1) | CA2458318C (OSRAM) |
| DE (1) | DE60213633T2 (OSRAM) |
| MX (1) | MXPA04002445A (OSRAM) |
| WO (1) | WO2003024183A2 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7081475B2 (en) * | 2001-09-14 | 2006-07-25 | Prolx Pharmaceuticals Corp. | Wortmannin analogs and methods of using same |
| DE10219545A1 (de) * | 2002-04-26 | 2003-11-06 | Lang Florian | Regulation der Apoptose |
| US7230139B2 (en) | 2002-12-05 | 2007-06-12 | Gemin X Biotechnologies | Diterpenoid compounds, compositions thereof and their use as anti-cancer or anti-fungal agents |
| MXPA05011248A (es) * | 2003-04-23 | 2005-12-14 | Wyeth Corp | Derivados de wortmanina solubles en agua. |
| DE102004043463A1 (de) * | 2004-06-09 | 2006-02-09 | Heinz Voigt | Mittel zur Krebsbekämpfung unter Verwendung von Schimmelpilzextrakten |
| JP5371426B2 (ja) | 2004-07-09 | 2013-12-18 | プロルックス ファーマシューティカルズ コープ． | ワートマニン類似体及び化学療法薬と組み合わせた同一物を使用する方法 |
| AR051388A1 (es) * | 2004-10-13 | 2007-01-10 | Wyeth Corp | Analogos de 17-hidroxiwortmanina como inhibidores de pi3k |
| WO2006132675A2 (en) * | 2004-12-20 | 2006-12-14 | University Of South Florida | Xiap-targeted prostate cancer therapy |
| CA2620855A1 (en) * | 2005-09-01 | 2007-08-02 | Beth Israel Deaconess Medical Center | Wortmannin conjugates and uses thereof |
| US20070116736A1 (en) * | 2005-11-23 | 2007-05-24 | Argentieri Dennis C | Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury |
| EP1965790B1 (en) * | 2005-12-30 | 2011-12-07 | Arizona Board of Regents, Acting on Behalf of The University of Arizona | Metabolites of wortmannin analogs and methods of using the same |
| EP2012794B1 (en) * | 2006-04-13 | 2014-09-17 | The Trustees of Columbia University in the City of New York | Compositions and intraluminal devices for inhibiting vascular stenosis |
| AU2011261243A1 (en) * | 2010-06-04 | 2012-12-20 | Oncothyreon Inc. | Combination cancer therapies with wortmannin analogs |
| JP2013527248A (ja) * | 2010-06-04 | 2013-06-27 | オンコシレオン インク． | ウォルトマンニンアナログによる癌の処置 |
| US11197854B1 (en) | 2018-11-14 | 2021-12-14 | National Technology & Engineering Solutions Of Sandia, Llc | Inhibitors for targeting flaviviruses |
| KR20210107069A (ko) | 2018-12-21 | 2021-08-31 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 컨쥬게이트와 키나아제 저해제의 조합 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2302021A (en) * | 1996-10-16 | 1997-01-08 | Lilly Co Eli | Inhibiting bone loss or resorption |
-
2002
- 2002-09-16 DE DE60213633T patent/DE60213633T2/de not_active Expired - Lifetime
- 2002-09-16 JP JP2003528088A patent/JP4540986B2/ja not_active Expired - Fee Related
- 2002-09-16 AT AT02766286T patent/ATE334671T1/de not_active IP Right Cessation
- 2002-09-16 AU AU2002330029A patent/AU2002330029B2/en not_active Ceased
- 2002-09-16 EP EP02766286A patent/EP1435941B8/en not_active Expired - Lifetime
- 2002-09-16 WO PCT/US2002/029365 patent/WO2003024183A2/en not_active Ceased
- 2002-09-16 CA CA2458318A patent/CA2458318C/en not_active Expired - Fee Related
- 2002-09-16 MX MXPA04002445A patent/MXPA04002445A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA2458318A1 (en) | 2003-03-27 |
| AU2002330029B2 (en) | 2006-07-06 |
| CA2458318C (en) | 2011-03-15 |
| EP1435941A2 (en) | 2004-07-14 |
| DE60213633D1 (de) | 2006-09-14 |
| EP1435941B1 (en) | 2006-08-02 |
| EP1435941B8 (en) | 2006-10-25 |
| EP1435941A4 (en) | 2004-12-08 |
| JP2005507880A (ja) | 2005-03-24 |
| JP4540986B2 (ja) | 2010-09-08 |
| WO2003024183A3 (en) | 2003-06-12 |
| DE60213633T2 (de) | 2007-11-08 |
| WO2003024183A2 (en) | 2003-03-27 |
| MXPA04002445A (es) | 2005-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |