ATE327221T1 - Diamide, die tryptase und faktor-xa-aktivität hemmen - Google Patents
Diamide, die tryptase und faktor-xa-aktivität hemmenInfo
- Publication number
- ATE327221T1 ATE327221T1 AT02724182T AT02724182T ATE327221T1 AT E327221 T1 ATE327221 T1 AT E327221T1 AT 02724182 T AT02724182 T AT 02724182T AT 02724182 T AT02724182 T AT 02724182T AT E327221 T1 ATE327221 T1 AT E327221T1
- Authority
- AT
- Austria
- Prior art keywords
- factor
- activity
- diamides
- inhibit tryptase
- tryptase
- Prior art date
Links
- 108010074860 Factor Xa Proteins 0.000 title abstract 3
- 230000000694 effects Effects 0.000 title abstract 2
- 108060005989 Tryptase Proteins 0.000 title 1
- 102000001400 Tryptase Human genes 0.000 title 1
- 150000001470 diamides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000006806 disease prevention Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Compounds Of Unknown Constitution (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01103662 | 2001-02-23 | ||
| EP01116782 | 2001-07-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE327221T1 true ATE327221T1 (de) | 2006-06-15 |
Family
ID=26076479
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02724182T ATE327221T1 (de) | 2001-02-23 | 2002-02-22 | Diamide, die tryptase und faktor-xa-aktivität hemmen |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7256194B2 (enExample) |
| EP (1) | EP1370526B1 (enExample) |
| JP (1) | JP2004523560A (enExample) |
| AT (1) | ATE327221T1 (enExample) |
| AU (1) | AU2002254907A1 (enExample) |
| CA (1) | CA2437114A1 (enExample) |
| CY (1) | CY1105506T1 (enExample) |
| DE (1) | DE60211665T2 (enExample) |
| DK (1) | DK1370526T3 (enExample) |
| ES (1) | ES2260428T3 (enExample) |
| PT (1) | PT1370526E (enExample) |
| WO (1) | WO2002068390A1 (enExample) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0893437A4 (en) * | 1996-04-10 | 2000-12-27 | Ono Pharmaceutical Co | GUANIDINO TRYPTASE INHIBITOR |
| SI0921116T1 (en) * | 1997-12-04 | 2003-10-31 | F. Hoffmann - La Roche Ag | N-(4-carbamimido-phenyl)-glycine amide derivatives |
| DE19939910A1 (de) * | 1999-08-23 | 2001-03-01 | Morphochem Ag | Neue Verbindungen, die Tryptase-Aktivität hemmen |
| DE10041402A1 (de) * | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
-
2002
- 2002-02-22 DK DK02724182T patent/DK1370526T3/da active
- 2002-02-22 US US10/468,975 patent/US7256194B2/en not_active Expired - Fee Related
- 2002-02-22 ES ES02724182T patent/ES2260428T3/es not_active Expired - Lifetime
- 2002-02-22 PT PT02724182T patent/PT1370526E/pt unknown
- 2002-02-22 EP EP02724182A patent/EP1370526B1/en not_active Expired - Lifetime
- 2002-02-22 WO PCT/EP2002/001934 patent/WO2002068390A1/en not_active Ceased
- 2002-02-22 AU AU2002254907A patent/AU2002254907A1/en not_active Abandoned
- 2002-02-22 JP JP2002567904A patent/JP2004523560A/ja active Pending
- 2002-02-22 CA CA002437114A patent/CA2437114A1/en not_active Abandoned
- 2002-02-22 AT AT02724182T patent/ATE327221T1/de not_active IP Right Cessation
- 2002-02-22 DE DE60211665T patent/DE60211665T2/de not_active Expired - Lifetime
-
2006
- 2006-07-03 CY CY20061100900T patent/CY1105506T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1370526B1 (en) | 2006-05-24 |
| PT1370526E (pt) | 2006-08-31 |
| WO2002068390A8 (en) | 2002-10-31 |
| ES2260428T3 (es) | 2006-11-01 |
| DE60211665D1 (de) | 2006-06-29 |
| DE60211665T2 (de) | 2006-09-28 |
| WO2002068390A1 (en) | 2002-09-06 |
| CA2437114A1 (en) | 2002-09-06 |
| AU2002254907A1 (en) | 2002-09-12 |
| US7256194B2 (en) | 2007-08-14 |
| JP2004523560A (ja) | 2004-08-05 |
| US20040082547A1 (en) | 2004-04-29 |
| EP1370526A1 (en) | 2003-12-17 |
| CY1105506T1 (el) | 2010-04-28 |
| DK1370526T3 (da) | 2006-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1370526 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |