ATE326014T1 - Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma - Google Patents
Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasmaInfo
- Publication number
- ATE326014T1 ATE326014T1 AT99962732T AT99962732T ATE326014T1 AT E326014 T1 ATE326014 T1 AT E326014T1 AT 99962732 T AT99962732 T AT 99962732T AT 99962732 T AT99962732 T AT 99962732T AT E326014 T1 ATE326014 T1 AT E326014T1
- Authority
- AT
- Austria
- Prior art keywords
- ldl
- lipoprotein
- vldl
- compound
- plasma cholesterol
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- General Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10764498P | 1998-11-09 | 1998-11-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE326014T1 true ATE326014T1 (de) | 2006-06-15 |
Family
ID=22317677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99962732T ATE326014T1 (de) | 1998-11-09 | 1999-11-09 | Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1137948B1 (de) |
JP (1) | JP2002529740A (de) |
CN (1) | CN1332849A (de) |
AT (1) | ATE326014T1 (de) |
AU (1) | AU1911200A (de) |
CA (1) | CA2350316A1 (de) |
DE (1) | DE69931279T2 (de) |
IL (2) | IL143057A0 (de) |
MX (1) | MXPA01004683A (de) |
WO (1) | WO2000028332A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6670398B2 (en) | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
ES2283933T3 (es) | 1997-05-14 | 2007-11-01 | Atherogenics, Inc. | Ester del acido succinico de probucol para la inhibicion de la expresion de vcam-1. |
US6852878B2 (en) | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
CO5170498A1 (es) * | 1999-05-28 | 2002-06-27 | Abbott Lab | Biaril sulfonamidas son utiles como inhibidores de proliferacion celular |
EP1967514B1 (de) | 1999-10-04 | 2013-01-02 | Nippon Soda Co., Ltd. | Phenolverbindungen und Aufzeichnungselemente damit |
JP2003528109A (ja) * | 2000-03-21 | 2003-09-24 | アセロジエニクス・インコーポレイテツド | Vcam−1の発現を阻害するためのチオケタール及びチオエーテル |
EP1272465A2 (de) | 2000-04-11 | 2003-01-08 | Atherogenics, Inc. | Verfahren und zusammensetzungen zur erhöhung des hdl-plasmaspiegels |
CA2440680C (en) | 2001-03-12 | 2010-06-01 | Roberto Pellicciari | Steroids as agonists for fxr |
ITMI20020597A1 (it) * | 2002-03-22 | 2003-09-22 | Nicox Sa | Derivati del probucolo |
WO2005102323A2 (en) | 2004-04-20 | 2005-11-03 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
CN101686676A (zh) | 2007-03-26 | 2010-03-31 | 沙路特里亚制药有限责任公司 | 用于治疗糖尿病的方法和普罗布考衍生物的组合物 |
US8048880B2 (en) | 2007-05-03 | 2011-11-01 | Anthera Pharmaceuticals, Inc. | Treatment of cardiovascular disease and dyslipidemia using secretory phospholipase A2 (SPLA2) inhibitors and SPLA2 inhibitor combination therapies |
CA2765709A1 (en) * | 2009-06-17 | 2010-12-23 | Maine Standards Company, Llc | Method for measuring lipoprotein-specific apolipoproteins |
CN114085283A (zh) * | 2015-05-19 | 2022-02-25 | 拉·约拉过敏反应及免疫医学研究所 | 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途 |
CN109789217A (zh) * | 2016-09-01 | 2019-05-21 | 凯文·乔恩·威廉姆斯 | 用于降低脂蛋白颗粒对动脉壁酶引起的致动脉粥样硬化性聚集的敏感度的方法和试剂盒 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869534A (en) * | 1992-05-21 | 1999-02-09 | The Picower Institute For Medical Research | Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom |
US5155250A (en) * | 1990-07-05 | 1992-10-13 | Merrell Dow Pharmaceuticals Inc. | 2,6-di-alkyl-4-silyl-phenols as antiatheroscerotic agents |
DK1468692T3 (da) * | 1993-12-10 | 2006-08-28 | Aventis Inc | Anvendelse af 2,6-di-alkyl-4-silyl-phenoler til behandling af xantom |
US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
CH691957A5 (de) * | 1996-09-03 | 2001-12-14 | Urs Tschudin | Schleifmaschine. |
-
1999
- 1999-11-09 WO PCT/US1999/026519 patent/WO2000028332A1/en active IP Right Grant
- 1999-11-09 AU AU19112/00A patent/AU1911200A/en not_active Abandoned
- 1999-11-09 IL IL14305799A patent/IL143057A0/xx unknown
- 1999-11-09 CA CA002350316A patent/CA2350316A1/en not_active Abandoned
- 1999-11-09 MX MXPA01004683A patent/MXPA01004683A/es active IP Right Grant
- 1999-11-09 AT AT99962732T patent/ATE326014T1/de not_active IP Right Cessation
- 1999-11-09 CN CN99815245A patent/CN1332849A/zh active Pending
- 1999-11-09 DE DE69931279T patent/DE69931279T2/de not_active Expired - Lifetime
- 1999-11-09 EP EP99962732A patent/EP1137948B1/de not_active Expired - Lifetime
- 1999-11-09 JP JP2000581459A patent/JP2002529740A/ja active Pending
-
2001
- 2001-05-09 IL IL143057A patent/IL143057A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MXPA01004683A (es) | 2002-09-18 |
JP2002529740A (ja) | 2002-09-10 |
WO2000028332A9 (en) | 2000-09-28 |
AU1911200A (en) | 2000-05-29 |
WO2000028332A1 (en) | 2000-05-18 |
DE69931279T2 (de) | 2007-04-12 |
CA2350316A1 (en) | 2000-05-18 |
EP1137948A1 (de) | 2001-10-04 |
EP1137948B1 (de) | 2006-05-10 |
CN1332849A (zh) | 2002-01-23 |
IL143057A0 (en) | 2002-04-21 |
IL143057A (en) | 2010-04-15 |
DE69931279D1 (de) | 2006-06-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE326014T1 (de) | Methode und zusammensetzungen zum vermindern des cholesterolspiegels im plasma | |
Roberts et al. | A cell-based model of thrombin generation | |
Oka et al. | Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive | |
Barrans et al. | Hepatic lipase induces the formation of pre-beta 1 high density lipoprotein (HDL) from triacylglycerol-rich HDL2. A study comparing liver perfusion to in vitro incubation with lipases | |
Marais et al. | Dysbetalipoproteinaemia: a mixed hyperlipidaemia of remnant lipoproteins due to mutations in apolipoprotein E | |
Bersot et al. | Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts. | |
ZA200107598B (en) | Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein Al, very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol. | |
MY121405A (en) | 4-amino substituted-2-substituted-1,2,3,4-tetrahydroquinolines | |
MY130670A (en) | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines | |
MY121838A (en) | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines | |
EP1155121A4 (de) | Zusammensetzungen und verfahren zur regulierung des serumcholesterins | |
TW200510452A (en) | Compositions and methods for treating atherosclerosis | |
AU2864195A (en) | Class bi and ci scavenger receptors | |
WO2004005481A3 (en) | Methods for identifying modulators of mda-7 mediated apoptosis | |
IL160533A0 (en) | Methods of screening molecules that are used to prevent cardiovascular diseases | |
Soutar et al. | The characterization of lipoproteins in the high density fraction obtained from patients with familial lecithin: cholesterol acyltransferase deficiency and their interaction with cultured human fibroblasts. | |
DE69716057D1 (de) | Verfahren und zusammensetzungen zum nachweis von spleiss-mutationen in dihydropyremudine dehydrogenase | |
de Man et al. | Effect of apolipoprotein E variants on lipolysis of very low density lipoproteins by heparan sulphate proteoglycan-bound lipoprotein lipase | |
De Cristofaro et al. | Plasma protein oxidation is associated with an increase of procoagulant markers causing an imbalance between pro-and anticoagulant pathways in healthy subjects | |
Minnich et al. | Identification and characterization of a novel apolipoprotein E variant, apolipoprotein E3'(Arg136–> His): association with mild dyslipidemia and double pre-beta very low density lipoproteins | |
Morton et al. | Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition | |
Caron et al. | A blinded in vitro study with Refacto® mock plasma samples: similar FVIII results between the chromogenic assay and a one‐stage assay when using a higher cephalin dilution | |
Chung et al. | Lipolytic remnants of human VLDL produced in vitro: effect of HDL levels in the lipolysis mixtures on the apoCs to apoE ratio and metabolic properties of VLDL core remnants | |
Adolph | Cell cycle variations in ADP-ribosylation of HeLa nuclear proteins | |
AU6193699A (en) | Antisense-sequences for inhibiting the expression of the adhesion molecule icam-1 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |