ATE324897T1 - Verwendung von noribogain derivaten zur behandlung von chemischer abhängigkeit bei säugern - Google Patents

Verwendung von noribogain derivaten zur behandlung von chemischer abhängigkeit bei säugern

Info

Publication number
ATE324897T1
ATE324897T1 AT95927295T AT95927295T ATE324897T1 AT E324897 T1 ATE324897 T1 AT E324897T1 AT 95927295 T AT95927295 T AT 95927295T AT 95927295 T AT95927295 T AT 95927295T AT E324897 T1 ATE324897 T1 AT E324897T1
Authority
AT
Austria
Prior art keywords
noribogain
mammals
derivatives
chemical dependency
treat chemical
Prior art date
Application number
AT95927295T
Other languages
English (en)
Inventor
Deborah C Mash
Juan Sanchez-Ramos
W Lee Hearn
Original Assignee
Nda Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nda Int Inc filed Critical Nda Int Inc
Application granted granted Critical
Publication of ATE324897T1 publication Critical patent/ATE324897T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
AT95927295T 1994-07-25 1995-07-25 Verwendung von noribogain derivaten zur behandlung von chemischer abhängigkeit bei säugern ATE324897T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28018794A 1994-07-25 1994-07-25

Publications (1)

Publication Number Publication Date
ATE324897T1 true ATE324897T1 (de) 2006-06-15

Family

ID=23072046

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927295T ATE324897T1 (de) 1994-07-25 1995-07-25 Verwendung von noribogain derivaten zur behandlung von chemischer abhängigkeit bei säugern

Country Status (11)

Country Link
US (1) US6348456B1 (de)
EP (1) EP0804200B1 (de)
AT (1) ATE324897T1 (de)
AU (1) AU4613296A (de)
DE (1) DE69534975T2 (de)
DK (1) DK0804200T3 (de)
ES (1) ES2264562T3 (de)
IL (1) IL114726A (de)
MX (1) MX9701430A (de)
PT (1) PT804200E (de)
WO (1) WO1996003127A1 (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003200404B2 (en) * 1997-09-04 2006-06-29 Demerx, Inc. Noribogaine in the treatment of pain and drug addiction
IL134796A0 (en) * 1997-09-04 2001-04-30 Novoneuron Inc Noribogaine in the treatment of pain and drug addiction
US7220737B1 (en) 1997-09-04 2007-05-22 Novoneuron, Inc Noribogaine in the treatment of pain and drug addiction
BR0106261A (pt) * 2001-12-26 2003-09-02 Fundacao Oswaldo Cruz Composições medicamentosas contendo alcalóides indólicos para o tratamento da aids
US20030153552A1 (en) * 2002-02-14 2003-08-14 Mash Deborah C. Method of treating chemical dependency in mammals and a composition therefor
GB2480632A (en) 2010-05-25 2011-11-30 Kythera Biopharmaceuticals Inc Preparation of 12-keto and 12-alpha-hydroxy steroids
US8765737B1 (en) 2010-05-11 2014-07-01 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US8362007B1 (en) 2010-05-11 2013-01-29 Demerx, Inc. Substituted noribogaine
US9394294B2 (en) 2010-05-11 2016-07-19 Demerx, Inc. Methods and compositions for preparing and purifying noribogaine
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
US8741891B1 (en) 2010-06-22 2014-06-03 Demerx, Inc. N-substituted noribogaine prodrugs
US8802832B2 (en) 2010-06-22 2014-08-12 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
US8637648B1 (en) 2010-06-22 2014-01-28 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
AU2012202509B2 (en) * 2010-07-23 2014-02-13 Demerx, Inc. Noribogaine compositions
JP6049615B2 (ja) * 2010-07-23 2016-12-21 デマークス・インコーポレイテッドＤｅｍｅｒｘ，Ｉｎｃ． ノリボガイン組成物
EP2481740B1 (de) 2011-01-26 2015-11-04 DemeRx, Inc. Verfahren und Zusammensetzungen zur Herstellung von Noribogain aus Voacangin
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
PE20142353A1 (es) * 2011-09-15 2015-01-10 Demerx Inc Ansolvatos de sal de noribogaina
EP2788355A4 (de) 2011-12-08 2015-10-21 Demerx Inc Stereoselektive totalsynthese von noribogain
WO2013085922A1 (en) * 2011-12-09 2013-06-13 Demerx, Inc. Phosphate esters of noribogaine
CA2855990A1 (en) 2011-12-09 2013-06-13 Demerx, Inc. Sulfate esters of noribogaine
WO2013112673A1 (en) 2012-01-25 2013-08-01 Demerx, Inc. Synthetic voacangine
US9150584B2 (en) 2012-01-25 2015-10-06 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
WO2013112163A1 (en) * 2012-01-25 2013-08-01 Demerx, Inc. Indole and benzofuran fused isoquinuclidene derivatives and processes for preparing them
EP2934541A4 (de) * 2012-12-20 2016-08-03 Demerx Inc Substituiertes noribogain
US9045481B2 (en) 2012-12-20 2015-06-02 Demerx, Inc. Substituted noribogaine
US8940728B2 (en) 2012-12-20 2015-01-27 Demerx, Inc. Substituted noribogaine
WO2014143201A1 (en) 2013-03-15 2014-09-18 Demerx, Inc. Method for noribogaine treatment of addiction in patients on methadone
WO2015112168A2 (en) * 2014-01-24 2015-07-30 Demerx, Inc. Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier
JP2017509612A (ja) 2014-02-18 2017-04-06 デメルクス，インコーポレイテッド 薬物中毒の急性および長期間での治療方法。
US9345711B2 (en) 2014-02-18 2016-05-24 Demerx, Inc. Methods for acute and long-term treatment of drug addiction
US9561232B2 (en) 2014-02-18 2017-02-07 Demerx, Inc. Low dose noribogaine for treating nicotine addiction and preventing relapse of nicotine use
WO2015126836A2 (en) * 2014-02-18 2015-08-27 Demerx, Inc. Therapeutic methods employing noribogaine and related compounds
US9591978B2 (en) 2014-03-13 2017-03-14 Demerx, Inc. Methods and compositions for pre-screening patients for treatment with noribogaine
US9550789B2 (en) 2014-06-18 2017-01-24 Demerx, Inc. Halogenated indole and benzofuran derivatives of isoquinuclidene and processes for preparing them
US9549935B2 (en) 2014-07-14 2017-01-24 Demerx, Inc. Methods and compositions for treating migraines using noribogaine
EP4279134A1 (de) 2014-11-26 2023-11-22 DemeRx, Inc. Verfahren und zusammensetzungen zur potenzierung der wirkung von opioidanalgetika mithilfe von iboga-alkaloiden
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
EP3955918A1 (de) 2019-04-17 2022-02-23 COMPASS Pathfinder Limited Verfahren zur behandlung neurokognitiver störungen, chronischer schmerzen und verringerung von entzündung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3516989A (en) * 1967-10-02 1970-06-23 American Home Prod Intermediates for total synthesis of iboga alkaloids and means of preparation
US4499096A (en) * 1983-11-18 1985-02-12 Lotsof Howard S Rapid method for interrupting the narcotic addiction syndrome
US4587243A (en) * 1985-07-15 1986-05-06 Lotsof Howard S Rapid method for interrupting the cocaine and amphetamine abuse syndrome
US5152994A (en) * 1990-05-31 1992-10-06 Lotsof Howard S Rapid method for interrupting or attenuating poly-drug dependency syndromes
US5591738A (en) * 1994-10-14 1997-01-07 Nda International, Inc. Method of treating chemical dependency using β-carboline alkaloids, derivatives and salts thereof

Also Published As

Publication number Publication date
DK0804200T3 (da) 2006-09-11
EP0804200B1 (de) 2006-05-03
WO1996003127A1 (en) 1996-02-08
EP0804200A1 (de) 1997-11-05
US6348456B1 (en) 2002-02-19
IL114726A0 (en) 1995-11-27
PT804200E (pt) 2006-09-29
AU4613296A (en) 1996-04-19
DE69534975D1 (de) 2006-06-08
IL114726A (en) 2002-04-21
ES2264562T3 (es) 2007-01-01
MX9701430A (es) 1997-12-31
EP0804200A4 (de) 1999-06-23
DE69534975T2 (de) 2007-01-11

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