ATE318617T1 - Synthetische oligonukleotide als erythroid differenzierungserreger - Google Patents
Synthetische oligonukleotide als erythroid differenzierungserregerInfo
- Publication number
- ATE318617T1 ATE318617T1 AT01931516T AT01931516T ATE318617T1 AT E318617 T1 ATE318617 T1 AT E318617T1 AT 01931516 T AT01931516 T AT 01931516T AT 01931516 T AT01931516 T AT 01931516T AT E318617 T1 ATE318617 T1 AT E318617T1
- Authority
- AT
- Austria
- Prior art keywords
- erythroid differentiation
- synthetic oligonucleotides
- differentiation agents
- sequences corresponding
- globin gene
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- 230000004069 differentiation Effects 0.000 title abstract 2
- 230000000925 erythroid effect Effects 0.000 title abstract 2
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 108091005886 Hemoglobin subunit gamma Proteins 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 150000007523 nucleic acids Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Fats And Perfumes (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000TO000234A IT1320168B1 (it) | 2000-03-13 | 2000-03-13 | Oligonucleotidi sintetici in grado di indurre il differenziamentoeritroide. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE318617T1 true ATE318617T1 (de) | 2006-03-15 |
Family
ID=11457577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01931516T ATE318617T1 (de) | 2000-03-13 | 2001-03-13 | Synthetische oligonukleotide als erythroid differenzierungserreger |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7262175B2 (de) |
| EP (1) | EP1263475B1 (de) |
| AT (1) | ATE318617T1 (de) |
| AU (1) | AU2001258274A1 (de) |
| BR (1) | BR0109365A (de) |
| DE (1) | DE60117532D1 (de) |
| IT (1) | IT1320168B1 (de) |
| WO (1) | WO2001068147A2 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITTO20020582A1 (it) * | 2002-07-04 | 2004-01-05 | Univ Ferrara | Nuovo uso della rapamicina e di suoi analoghi strutturali |
| DE102005061932A1 (de) | 2005-12-23 | 2007-07-05 | Biedermann Motech Gmbh | Mehrwandiger Platzhalter |
| ES2661787T3 (es) * | 2009-05-01 | 2018-04-04 | Curna, Inc. | Tratamiento de enfermedades relacionadas con hemoglobina (hbf/hbg) por inhibición de transcrito antisentido natural para hbf/hbg |
| TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6022738A (en) * | 1995-03-03 | 2000-02-08 | Mount Sinai School Of Medicine Of The City University Of New York | Vectors for expression of globin genes |
| AU6328696A (en) | 1995-06-07 | 1996-12-30 | Yale University | Treatment of hemoglobinopathies |
| KR19990063761A (ko) * | 1995-09-26 | 1999-07-26 | 엘. 데이예를 카렌. | 헤르페스 비루스에 속하는 rfhv/kshv 아과의 당단백질b |
| US5763488A (en) * | 1995-10-30 | 1998-06-09 | Vertex Pharmaceuticals Incorporated | Methods and compositions using butyrate esters of threitol |
-
2000
- 2000-03-13 IT IT2000TO000234A patent/IT1320168B1/it active
-
2001
- 2001-03-13 WO PCT/EP2001/002804 patent/WO2001068147A2/en active IP Right Grant
- 2001-03-13 DE DE60117532T patent/DE60117532D1/de not_active Expired - Fee Related
- 2001-03-13 EP EP01931516A patent/EP1263475B1/de not_active Expired - Lifetime
- 2001-03-13 AU AU2001258274A patent/AU2001258274A1/en not_active Abandoned
- 2001-03-13 AT AT01931516T patent/ATE318617T1/de not_active IP Right Cessation
- 2001-03-13 BR BR0109365-7A patent/BR0109365A/pt not_active IP Right Cessation
- 2001-03-13 US US10/220,310 patent/US7262175B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ITTO20000234A1 (it) | 2001-09-13 |
| WO2001068147A2 (en) | 2001-09-20 |
| DE60117532D1 (de) | 2006-04-27 |
| EP1263475A2 (de) | 2002-12-11 |
| IT1320168B1 (it) | 2003-11-18 |
| ITTO20000234A0 (it) | 2000-03-13 |
| EP1263475B1 (de) | 2006-03-01 |
| US7262175B2 (en) | 2007-08-28 |
| BR0109365A (pt) | 2002-12-24 |
| WO2001068147A3 (en) | 2001-12-13 |
| US20030073660A1 (en) | 2003-04-17 |
| AU2001258274A1 (en) | 2001-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE172468T1 (de) | Synthetische katalytische oligonukleotide | |
| ATE484586T1 (de) | Synthetische doppelsträngige oligonucleotide zur gezielten hemmung der genexpression | |
| DK1569661T3 (da) | Antisense design | |
| ATE460481T1 (de) | Verfahren zur hemmung der expression eines zielgens und medikament zur therapie einer tumorerkrankung | |
| MXPA02009627A (es) | Modificaciones genomicas cromosomicas selectivas con oligonucleotidos modificados de un solo filamento.. | |
| KR950702626A (ko) | 치료제로서 자체-안정화된 올리고누클레오티드(self-stabilized loigonucleotides as therapeutic agents) | |
| ATE407224T1 (de) | Annealing-kontrollprimer und seine verwendungen | |
| PL328639A1 (en) | Synthesis of p5' phosphoamidane oligonucleotides n3' | |
| DK0691980T3 (da) | 7-deazapurinmodifiderende oligonukleotider | |
| WO2004078941A3 (en) | Modulation of gene expression using dna-rna hybrids | |
| ATE318617T1 (de) | Synthetische oligonukleotide als erythroid differenzierungserreger | |
| ES2112062T3 (es) | Oligonucleotidos con actividad anti-citomegalovirus. | |
| WO2002036828A3 (en) | COMPOSITIONS AND SYSTEMS FOR IDENTIFYING AND COMPARING EXPRESSED GENES (mRNAs) IN EUKARYOTIC ORGANISMS | |
| WO2003031459A3 (de) | Modulation der expression stat-1-abhängiger gene | |
| DE60140552D1 (de) | Transglutaminase genprodukte |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |