ATE314348T1 - 1-acyl-7-nitroindolin derivate, deren herstellung und deren verwendung als photospaltbare vorstufen - Google Patents
1-acyl-7-nitroindolin derivate, deren herstellung und deren verwendung als photospaltbare vorstufenInfo
- Publication number
- ATE314348T1 ATE314348T1 AT00911095T AT00911095T ATE314348T1 AT E314348 T1 ATE314348 T1 AT E314348T1 AT 00911095 T AT00911095 T AT 00911095T AT 00911095 T AT00911095 T AT 00911095T AT E314348 T1 ATE314348 T1 AT E314348T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- substituted alkyl
- effector moiety
- photosplitable
- Prior art date
Links
- 239000002243 precursor Substances 0.000 title 1
- 239000012636 effector Substances 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 4
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906192.1A GB9906192D0 (en) | 1999-03-18 | 1999-03-18 | Photoreleasable compounds |
| PCT/GB2000/001039 WO2000055133A1 (en) | 1999-03-18 | 2000-03-20 | 1-acyl-7-nitroindoline derivatives, their preparation and their use as photocleavable precursors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE314348T1 true ATE314348T1 (de) | 2006-01-15 |
Family
ID=10849843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00911095T ATE314348T1 (de) | 1999-03-18 | 2000-03-20 | 1-acyl-7-nitroindolin derivate, deren herstellung und deren verwendung als photospaltbare vorstufen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6765014B1 (de) |
| EP (1) | EP1161418B1 (de) |
| JP (1) | JP2002539196A (de) |
| AT (1) | ATE314348T1 (de) |
| AU (1) | AU3308900A (de) |
| CA (1) | CA2368150A1 (de) |
| DE (1) | DE60025171T2 (de) |
| GB (1) | GB9906192D0 (de) |
| WO (1) | WO2000055133A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200600497A (en) * | 2001-02-02 | 2006-01-01 | Sankyo Co | Preparation of indoline derivative |
| GB0109093D0 (en) * | 2001-04-11 | 2001-05-30 | Medical Res Council | Process for producing photocleavable compounds |
| GB0307231D0 (en) * | 2003-03-28 | 2003-04-30 | Medical Res Council | 7-Nitroindoline derivatives and their uses |
| EP1757585B1 (de) | 2005-08-26 | 2010-12-01 | Medical Research Council | Anionisch substituierte 7-Nitroindol Derivate und deren Verwendung |
| WO2013050795A1 (en) * | 2011-10-03 | 2013-04-11 | Femtonics Kft. | Use of photoactive compounds |
| US11370757B2 (en) * | 2017-10-18 | 2022-06-28 | Board Of Regents, The University Of Texas System | Photocleavable nitroindoline-based crosslinkers |
| CN112479971B (zh) * | 2020-12-09 | 2022-08-26 | 新乡医学院 | 2-溴-1-(7-硝基二氢吲哚)十六烷酮化合物及其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL48421A (en) * | 1975-11-04 | 1979-10-31 | Yeda Res & Dev | Method for the reversible blocking of acyl groups during organic synthesis using 7-nitroindoline derivatives as blocking agents |
| US4210590A (en) | 1978-01-06 | 1980-07-01 | Mcneil Laboratories, Incorporated | Reduction of indole compounds to indoline compounds |
| US4625014A (en) * | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| DE19514579A1 (de) | 1995-04-20 | 1996-10-24 | Boehringer Ingelheim Kg | Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz |
-
1999
- 1999-03-18 GB GBGB9906192.1A patent/GB9906192D0/en not_active Ceased
-
2000
- 2000-03-20 US US09/936,975 patent/US6765014B1/en not_active Expired - Lifetime
- 2000-03-20 DE DE60025171T patent/DE60025171T2/de not_active Expired - Lifetime
- 2000-03-20 CA CA002368150A patent/CA2368150A1/en not_active Abandoned
- 2000-03-20 AT AT00911095T patent/ATE314348T1/de not_active IP Right Cessation
- 2000-03-20 JP JP2000605564A patent/JP2002539196A/ja active Pending
- 2000-03-20 AU AU33089/00A patent/AU3308900A/en not_active Abandoned
- 2000-03-20 EP EP00911095A patent/EP1161418B1/de not_active Expired - Lifetime
- 2000-03-20 WO PCT/GB2000/001039 patent/WO2000055133A1/en active Search and Examination
Also Published As
| Publication number | Publication date |
|---|---|
| DE60025171T2 (de) | 2006-08-10 |
| WO2000055133A1 (en) | 2000-09-21 |
| JP2002539196A (ja) | 2002-11-19 |
| US6765014B1 (en) | 2004-07-20 |
| GB9906192D0 (en) | 1999-05-12 |
| EP1161418B1 (de) | 2005-12-28 |
| DE60025171D1 (de) | 2006-02-02 |
| EP1161418A1 (de) | 2001-12-12 |
| CA2368150A1 (en) | 2000-09-21 |
| AU3308900A (en) | 2000-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |