ES2076247T3 - Derivados de la pteridina farmaceuticamente eficaces. - Google Patents
Derivados de la pteridina farmaceuticamente eficaces.Info
- Publication number
- ES2076247T3 ES2076247T3 ES90107110T ES90107110T ES2076247T3 ES 2076247 T3 ES2076247 T3 ES 2076247T3 ES 90107110 T ES90107110 T ES 90107110T ES 90107110 T ES90107110 T ES 90107110T ES 2076247 T3 ES2076247 T3 ES 2076247T3
- Authority
- ES
- Spain
- Prior art keywords
- radical
- carbon atoms
- denotes hydrogen
- alkyl radical
- denotes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
- C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
EL INVENTO CONCIERNE A LOS COMPUESTOS DE PTERIDINA ACTIVOS COMO FARMACOS, DE FORMULA I (FORMULA), EN LA QUE A SIGNIFICA UN RESTO DE HIDROCARBURO, EVENTUALMENTE SUSTITUIDO, CON 1 A 8 ATOMOS DE C, QUE CONTIENE UN RESTO R3-C-R3 UNIDO DIRECTAMENTE AL RESTO FENILO Y R1 SIGNIFICA HIDROGENO, O UN RESTO CICLOALQUILO CON UN MAXIMO DE 7 ATOMOS DE C FORMANDO CICLO, O UN RESTO ALQUILO CON 1 A 5 ATOMOS DE C, O UN RESTO BENCILO, O UN RESTO AROMATICO AR; R2 ES HIDROGENO, O UN RESTO ALQUILO CON 1 A 8 ATOMOS DE C, O BIEN R1 Y R2, EVENTUALMENTE INCLUYENDO OTROS HETEROATOMOS DEL GRUPO FORMADO POR NITROGENO, OXIGENO O AZUFRE, FORMAN UN HETEROCICLO DE 5 O 6 ESLABONES; R3 SIGNIFICA HIDROGENO O UN RESTO ALQUILO CON 1 A 3 ATOMOS DE C; R3 ES HIDROGENO O UN RESTO ALQUILO CON 1 A 3 ATOMOS DE C, EVENTUALMENTE SUSTITUIDO, O UN GRUPO CARBOXILO, O UN GRUPO -OH, O BIEN FORMA PARTE DE UN RESTO DE CICLOALQUILO. TAMBIEN CONCIERNE LAS SALES DE ACIDO INOFENSIVAS EN FARMACIA, QUE SE DERIVAN DE ELLOS POR ADICION.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3913142A DE3913142A1 (de) | 1989-04-21 | 1989-04-21 | Pharmazeutisch wirksame pteridinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2076247T3 true ES2076247T3 (es) | 1995-11-01 |
Family
ID=6379151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90107110T Expired - Lifetime ES2076247T3 (es) | 1989-04-21 | 1990-04-12 | Derivados de la pteridina farmaceuticamente eficaces. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5124326A (es) |
| EP (1) | EP0393534B1 (es) |
| JP (1) | JPH02292287A (es) |
| AT (1) | ATE124948T1 (es) |
| CA (1) | CA2015049C (es) |
| DE (2) | DE3913142A1 (es) |
| DK (1) | DK0393534T3 (es) |
| ES (1) | ES2076247T3 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6711436B1 (en) | 1997-08-08 | 2004-03-23 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
| US6060454A (en) * | 1997-08-08 | 2000-05-09 | Duke University | Compositions, apparatus and methods for facilitating surgical procedures |
| CN106967069A (zh) * | 2017-03-22 | 2017-07-21 | 盐城市麦迪科化学品制造有限公司 | 一种氨苯蝶啶的制备方法 |
| CN106977410A (zh) * | 2017-05-15 | 2017-07-25 | 张家港威胜生物医药有限公司 | 一种由芴制备本芴醇中间体α‑（二正丁胺基）‑2，7‑二氯‑4‑芴甲醇的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3081230A (en) * | 1960-09-08 | 1963-03-12 | Smith Kline French Lab | Diuretic and antihypertensive triaminoarylpteridines |
| DE1620667A1 (de) * | 1965-12-14 | 1970-08-20 | Dresden Arzneimittel | Verfahren zur Herstellung von 2,4,7-Triaminopteridinen |
| US4252809A (en) * | 1977-01-03 | 1981-02-24 | Rohm Pharma Gmbh | Substituted pteridine compounds and pharmaceutical compositions containing the same |
| GB1599881A (en) * | 1977-02-02 | 1981-10-07 | Millington A R | Preparation for diagnostic radiology |
| EP0059524A1 (en) * | 1981-02-09 | 1982-09-08 | Smith and Nephew Associated Companies p.l.c. | Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines |
| DE3407695A1 (de) * | 1984-03-02 | 1985-09-12 | Röhm Pharma GmbH, 6108 Weiterstadt | Pteridinverbindungen mit pharmazeutischer wirksamkeit |
| DE3412765C2 (de) * | 1984-04-05 | 1997-06-05 | Roehm Pharma Gmbh | Triaminoarylpteridinverbindungen |
| DE3448490C2 (de) * | 1984-04-05 | 1995-04-27 | Roehm Pharma Gmbh | Verwendung von Pteridinderivaten zur Behandlung von Herzarrhythmien |
| DE3740441A1 (de) * | 1987-11-28 | 1989-06-08 | Roehm Gmbh | Pharmazeutisch wirksame pteridinderivate |
-
1989
- 1989-04-21 DE DE3913142A patent/DE3913142A1/de not_active Withdrawn
-
1990
- 1990-04-12 ES ES90107110T patent/ES2076247T3/es not_active Expired - Lifetime
- 1990-04-12 DK DK90107110.0T patent/DK0393534T3/da active
- 1990-04-12 DE DE59009388T patent/DE59009388D1/de not_active Expired - Fee Related
- 1990-04-12 AT AT90107110T patent/ATE124948T1/de not_active IP Right Cessation
- 1990-04-12 EP EP90107110A patent/EP0393534B1/de not_active Expired - Lifetime
- 1990-04-19 JP JP2101880A patent/JPH02292287A/ja active Pending
- 1990-04-20 CA CA002015049A patent/CA2015049C/en not_active Expired - Lifetime
- 1990-04-20 US US07/513,001 patent/US5124326A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0393534T3 (da) | 1995-10-02 |
| EP0393534A3 (de) | 1992-02-26 |
| DE59009388D1 (de) | 1995-08-17 |
| US5124326A (en) | 1992-06-23 |
| JPH02292287A (ja) | 1990-12-03 |
| ATE124948T1 (de) | 1995-07-15 |
| DE3913142A1 (de) | 1990-10-31 |
| CA2015049C (en) | 1997-10-21 |
| EP0393534A2 (de) | 1990-10-24 |
| CA2015049A1 (en) | 1990-10-21 |
| EP0393534B1 (de) | 1995-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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