ATE30589T1 - Ester von cyproheptadin-3-carbonsaeure und verbindungen, die eine aehnliche struktur aufweisen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. - Google Patents
Ester von cyproheptadin-3-carbonsaeure und verbindungen, die eine aehnliche struktur aufweisen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.Info
- Publication number
- ATE30589T1 ATE30589T1 AT83103380T AT83103380T ATE30589T1 AT E30589 T1 ATE30589 T1 AT E30589T1 AT 83103380 T AT83103380 T AT 83103380T AT 83103380 T AT83103380 T AT 83103380T AT E30589 T1 ATE30589 T1 AT E30589T1
- Authority
- AT
- Austria
- Prior art keywords
- emesis
- esters
- dyspepsia
- cyproheptadine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/368,257 US4412999A (en) | 1982-04-14 | 1982-04-14 | Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds |
| EP83103380A EP0092114B1 (de) | 1982-04-14 | 1983-04-07 | Ester von Cyproheptadin-3-carbonsäure und Verbindungen, die eine ähnliche Struktur aufweisen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE30589T1 true ATE30589T1 (de) | 1987-11-15 |
Family
ID=23450498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83103380T ATE30589T1 (de) | 1982-04-14 | 1983-04-07 | Ester von cyproheptadin-3-carbonsaeure und verbindungen, die eine aehnliche struktur aufweisen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4412999A (de) |
| EP (1) | EP0092114B1 (de) |
| JP (1) | JPS58188879A (de) |
| KR (1) | KR880002042B1 (de) |
| AT (1) | ATE30589T1 (de) |
| AU (1) | AU556530B2 (de) |
| CA (1) | CA1203798A (de) |
| DE (1) | DE3374312D1 (de) |
| DK (1) | DK161983A (de) |
| ES (1) | ES521359A0 (de) |
| GR (1) | GR78832B (de) |
| IE (1) | IE55033B1 (de) |
| IL (1) | IL68306A (de) |
| NZ (1) | NZ203786A (de) |
| PT (1) | PT76501B (de) |
| ZA (1) | ZA832589B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522821A (en) * | 1982-04-14 | 1985-06-11 | Merck & Co., Inc. | Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds |
| US4501749A (en) * | 1983-10-31 | 1985-02-26 | Merck & Co., Inc. | Peripherally selective dopamine antagonists in the treatment of ocular hypertension |
| GB8520662D0 (en) * | 1985-08-17 | 1985-09-25 | Wellcome Found | Tricyclic aromatic compounds |
| CA2025398A1 (en) * | 1989-09-20 | 1992-03-15 | Timothy Gerard Dinan | Diagnosis and treatment of a disorder of the gastrointestinal tract |
| FR2877573B1 (fr) * | 2004-11-05 | 2007-02-02 | Debussy Holding Sa | Nouvelles compositions pharmaceutiques et leurs utilisations pour lutter contre les differentes formes d'accoutumance aux drogues |
| EP2067777B1 (de) * | 2006-09-29 | 2013-08-14 | Nippon Zoki Pharmaceutical Co., Ltd. | Oxepinderivat |
| ES2955693T3 (es) | 2012-12-24 | 2023-12-05 | Neurogastrx Inc | Métodos para el tratamiento de trastornos del tracto GI |
| US9844554B2 (en) | 2014-06-24 | 2017-12-19 | Neurogastrx, Inc. | Prodrugs of metopimazine |
| US10836757B1 (en) | 2020-04-02 | 2020-11-17 | Neurogastrx, Inc. | Polymorphic forms of metopimazine |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3014911A (en) * | 1958-09-29 | 1961-12-26 | Merck & Co Inc | Derivatives of dibenzo[a, e]cycloheptatriene |
| NL125839C (de) * | 1963-12-03 | |||
| US3981877A (en) * | 1972-08-14 | 1976-09-21 | Merck & Co., Inc. | Piperidylidene derivatives of carboxy-5H-dibenzo[a,d]cycloheptene |
| US4072756A (en) * | 1973-05-17 | 1978-02-07 | Sandoz Ltd. | Tricyclo piperidino ketones and soporific compositions thereof |
| US4086350A (en) * | 1974-11-06 | 1978-04-25 | Smithkline Corporation | Pharmaceutical compositions and method of producing anti-psychotic activity without extrapyramidal symptoms |
| NL173398C (nl) * | 1974-11-11 | Merck & Co Inc | Werkwijze ter bereiding van farmaceutische preparaten alsmede werkwijze ter bereiding van een aan een benzeenkern gesubstitueerd 1-methyl-4-(10,11-dihydro-5h-dibenzo (a,d)cyclohepten-5-ylideen)-piperidinederivaat. | |
| US4076714A (en) * | 1974-11-25 | 1978-02-28 | Merck & Co., Inc. | 1-Methyl-4-(2-carboxy-thioxanthen-9-ylidene)-piperidine an appetite stimulant and antihistaminic agent |
| US4160031A (en) * | 1975-03-28 | 1979-07-03 | Merck & Co., Inc. | Antihistaminic and appetite stimulating 10,11-dihydro-3-carboxycyproheptadine |
| US4066772A (en) * | 1975-07-21 | 1978-01-03 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
-
1982
- 1982-04-14 US US06/368,257 patent/US4412999A/en not_active Expired - Fee Related
-
1983
- 1983-04-05 PT PT76501A patent/PT76501B/pt unknown
- 1983-04-06 AU AU13188/83A patent/AU556530B2/en not_active Ceased
- 1983-04-06 NZ NZ203786A patent/NZ203786A/en unknown
- 1983-04-06 IL IL68306A patent/IL68306A/xx unknown
- 1983-04-07 EP EP83103380A patent/EP0092114B1/de not_active Expired
- 1983-04-07 AT AT83103380T patent/ATE30589T1/de not_active IP Right Cessation
- 1983-04-07 DE DE8383103380T patent/DE3374312D1/de not_active Expired
- 1983-04-11 ES ES521359A patent/ES521359A0/es active Granted
- 1983-04-11 CA CA000425633A patent/CA1203798A/en not_active Expired
- 1983-04-11 GR GR71048A patent/GR78832B/el unknown
- 1983-04-12 IE IE833/83A patent/IE55033B1/en unknown
- 1983-04-13 ZA ZA832589A patent/ZA832589B/xx unknown
- 1983-04-13 DK DK161983A patent/DK161983A/da not_active IP Right Cessation
- 1983-04-13 KR KR1019830001539A patent/KR880002042B1/ko not_active IP Right Cessation
- 1983-04-14 JP JP58064665A patent/JPS58188879A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1203798A (en) | 1986-04-29 |
| IE830833L (en) | 1983-10-14 |
| DK161983D0 (da) | 1983-04-13 |
| IE55033B1 (en) | 1990-05-09 |
| JPS58188879A (ja) | 1983-11-04 |
| EP0092114A2 (de) | 1983-10-26 |
| EP0092114A3 (en) | 1985-01-16 |
| ES8404686A1 (es) | 1984-05-16 |
| PT76501A (en) | 1983-05-01 |
| US4412999A (en) | 1983-11-01 |
| DE3374312D1 (en) | 1987-12-10 |
| ZA832589B (en) | 1984-11-28 |
| GR78832B (de) | 1984-10-02 |
| KR840004422A (ko) | 1984-10-15 |
| IL68306A (en) | 1986-09-30 |
| ES521359A0 (es) | 1984-05-16 |
| IL68306A0 (en) | 1983-07-31 |
| NZ203786A (en) | 1985-11-08 |
| AU1318883A (en) | 1983-10-20 |
| KR880002042B1 (ko) | 1988-10-13 |
| DK161983A (da) | 1983-10-15 |
| EP0092114B1 (de) | 1987-11-04 |
| AU556530B2 (en) | 1986-11-06 |
| PT76501B (en) | 1986-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |