ATE304552T1 - Methoden zur identifizierung von zusammensetzungen, die für die behandlung von fettleibigkeit nützlich sind, unter verwendung von foxc2 - Google Patents

Methoden zur identifizierung von zusammensetzungen, die für die behandlung von fettleibigkeit nützlich sind, unter verwendung von foxc2

Info

Publication number
ATE304552T1
ATE304552T1 AT01904775T AT01904775T ATE304552T1 AT E304552 T1 ATE304552 T1 AT E304552T1 AT 01904775 T AT01904775 T AT 01904775T AT 01904775 T AT01904775 T AT 01904775T AT E304552 T1 ATE304552 T1 AT E304552T1
Authority
AT
Austria
Prior art keywords
foxc2
human
gene
treatment
methods
Prior art date
Application number
AT01904775T
Other languages
English (en)
Inventor
Sven Enerbaeck
Peter Carlsson
Original Assignee
Leangene Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0000531A external-priority patent/SE0000531D0/xx
Priority claimed from SE0001982A external-priority patent/SE0001982D0/xx
Priority claimed from US09/587,945 external-priority patent/US6709860B1/en
Priority claimed from SE0004629A external-priority patent/SE0004629D0/xx
Application filed by Leangene Ab filed Critical Leangene Ab
Application granted granted Critical
Publication of ATE304552T1 publication Critical patent/ATE304552T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Obesity (AREA)
  • Animal Husbandry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT01904775T 2000-02-18 2001-02-16 Methoden zur identifizierung von zusammensetzungen, die für die behandlung von fettleibigkeit nützlich sind, unter verwendung von foxc2 ATE304552T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE0000531A SE0000531D0 (sv) 2000-02-18 2000-02-18 Animal model
SE0001982A SE0001982D0 (sv) 2000-05-26 2000-05-26 Animal model
US09/587,945 US6709860B1 (en) 1997-05-26 2000-06-06 Animal model
SE0004629A SE0004629D0 (sv) 2000-12-14 2000-12-14 Animal model III
PCT/SE2001/000339 WO2001060853A1 (en) 2000-02-18 2001-02-16 Transgenic animal model for obesity expressing foxc2

Publications (1)

Publication Number Publication Date
ATE304552T1 true ATE304552T1 (de) 2005-09-15

Family

ID=27484514

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01904775T ATE304552T1 (de) 2000-02-18 2001-02-16 Methoden zur identifizierung von zusammensetzungen, die für die behandlung von fettleibigkeit nützlich sind, unter verwendung von foxc2

Country Status (11)

Country Link
EP (1) EP1255774B1 (de)
JP (1) JP2003523192A (de)
AT (1) ATE304552T1 (de)
AU (2) AU2001232599B2 (de)
CA (1) CA2400342A1 (de)
DE (1) DE60113380T2 (de)
IL (1) IL150951A0 (de)
IS (1) IS6502A (de)
NO (1) NO20023709L (de)
NZ (1) NZ521005A (de)
WO (1) WO2001060853A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2421620A1 (en) * 2000-09-26 2002-04-04 Biovitrum Ab Promoter sequences
JP2005538930A (ja) * 2002-01-29 2005-12-22 リーンジーン・アクチボラゲット ヒトｆｏｘｃ２タンパク質およびｆｏｘｃ−２相互作用タンパク質の複合体
WO2005012570A1 (ja) * 2003-07-31 2005-02-10 Banyu Pharmaceutical Co., Ltd. Slc25a10による肥満治療に有効な化合物の評価方法
PT1701978E (pt) * 2003-12-03 2009-03-03 Whitehead Biomedical Inst Utilização de caderina-t solúvel no tratamento de distúrbios metabólicos
SE0400489D0 (sv) * 2004-02-27 2004-02-27 Biovitrum Ab Therapeutic proteins
KR101669140B1 (ko) * 2015-04-28 2016-10-26 (주)케어젠 항비만 및 항당뇨 효능을 갖는 펩타이드 및 이의 용도

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992006104A1 (en) * 1990-09-28 1992-04-16 The Dana-Farber Cancer Institute Adipocyte-specific dna sequences and use for the production of transgenic animals exhibiting altered fat metabolism
SE9701963D0 (sv) * 1997-05-26 1997-05-26 Pharmacia & Upjohn Ab Novel transcription factor
US6087107A (en) * 1998-04-15 2000-07-11 The University Of Iowa Research Foundation Therapeutics and diagnostics for congenital heart disease based on a novel human transcription factor

Also Published As

Publication number Publication date
IL150951A0 (en) 2003-02-12
NO20023709L (no) 2002-10-17
DE60113380D1 (de) 2005-10-20
NZ521005A (en) 2004-04-30
EP1255774B1 (de) 2005-09-14
WO2001060853A1 (en) 2001-08-23
AU3259901A (en) 2001-08-27
AU2001232599B2 (en) 2006-10-12
EP1255774A1 (de) 2002-11-13
JP2003523192A (ja) 2003-08-05
CA2400342A1 (en) 2001-08-23
NO20023709D0 (no) 2002-08-06
IS6502A (is) 2002-08-14
DE60113380T2 (de) 2006-06-29

Similar Documents

Publication Publication Date Title
Sarin et al. Conditional telomerase induction causes proliferation of hair follicle stem cells
Bragulla et al. Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia
Bryant et al. Intrinsic and extrinsic control of growth in developing organs
ATE455552T1 (de) Expression des active human factor ix im brustdrüsengewebe transgener tiere
DE60226335D1 (en) Aviäres expressionssystem für fremdproteine
KR20090029749A (ko) 특이적이고 선택적인 전기장 및 전자기장의 인가를 통한 생세포에서의 전환 성장 인자-베타 (ＴＧＦ-β) 유전자 발현의 조절
US20090209020A1 (en) collagenous matrix with improved porosity and tensile strength and preparation method therefore by using mechanical stimulation system
CN1842356A (zh) 生物电刺激、加速愈合、减轻疼痛或病原体失活的装置和方法
RS51859B (en) METHOD FOR ANTICIPATING THE RESPONSE TO TREATMENT OF HER DIMENSION INHIBITORS
ATE429640T1 (de) Diagnostischer assay zur bestimmung einer zellvermittelten immunantwort
ATE527378T1 (de) Antisense-modulation von p38-mitogen-aktivierter proteinkinase-expression
ATE304552T1 (de) Methoden zur identifizierung von zusammensetzungen, die für die behandlung von fettleibigkeit nützlich sind, unter verwendung von foxc2
Luo et al. Ex ovo electroporation for gene transfer into older chicken embryos
DE69832798D1 (de) Regulatorische sequenzen für die in-vivo-expression einer heterologen dns-sequenz in endothelzellen und ihre verwendungen.
Jiang et al. TGFβ promotes the basal phenotype of epidermal keratinocytes: transcriptional induction of K# 5 and K# 14 keratin genes
DE69737062D1 (de) Gentherapie für kongestives herzversagen
Assailly et al. Effect of weak inductively coupled pulsating currents on calcium uptake in embryonic chick tibia explants
CN101939409A (zh) 通过施加特异性和选择性电场和电磁场调控活细胞中成纤维细胞生长因子-2(fgf-2)基因的表达
ATE552272T1 (de) Myostatin-isoform
Cheng Biochemical effects of pulsed electromagnetic fields
FR2771102B1 (fr) Procede pour induire la differenciation osteoblastique de cellules de tissu adipeux extramedullaire humain
Meyer et al. Immunohistochemical demonstration of connexins in the developing feather follicle of the chicken
DE602004023927D1 (de) Ghrh zur verwendung bei der behandlung von chronischer niereninsuffizienz
DE3851398T2 (de) DNA-Fragmente, die ein für Milchsäurebakterien spezifisches Regulationsgebiet enthalten, zur Expression von Genen, die normalerweise heterologe Proteine kodieren.
ATE438715T1 (de) Verwendung von molekularbiologisch hergestellten, nicht-viralen wirkstoffen zur behandlung der akne

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties