ATE301191T1 - Motorneuronlebenserhaltungsgen: ein gen für spinale muskelatrophie - Google Patents
Motorneuronlebenserhaltungsgen: ein gen für spinale muskelatrophieInfo
- Publication number
- ATE301191T1 ATE301191T1 AT95402335T AT95402335T ATE301191T1 AT E301191 T1 ATE301191 T1 AT E301191T1 AT 95402335 T AT95402335 T AT 95402335T AT 95402335 T AT95402335 T AT 95402335T AT E301191 T1 ATE301191 T1 AT E301191T1
- Authority
- AT
- Austria
- Prior art keywords
- gene
- smn
- motor neuron
- present
- muscle atrophy
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 210000002161 motor neuron Anatomy 0.000 title abstract 2
- 206010028289 Muscle atrophy Diseases 0.000 title 1
- 230000020763 muscle atrophy Effects 0.000 title 1
- 201000000585 muscular atrophy Diseases 0.000 title 1
- 208000005264 motor neuron disease Diseases 0.000 abstract 4
- 208000002320 spinal muscular atrophy Diseases 0.000 abstract 4
- 101150113275 Smn gene Proteins 0.000 abstract 3
- 201000010901 lateral sclerosis Diseases 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 208000032319 Primary lateral sclerosis Diseases 0.000 abstract 2
- 206010046298 Upper motor neurone lesion Diseases 0.000 abstract 2
- 208000010428 Muscle Weakness Diseases 0.000 abstract 1
- 206010028372 Muscular weakness Diseases 0.000 abstract 1
- 102100021947 Survival motor neuron protein Human genes 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000000349 chromosome Anatomy 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 230000001953 sensory effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94402353A EP0708178A1 (de) | 1994-10-19 | 1994-10-19 | Motoneuronlebenserhaltungsgen: ein Gen für spinale Muskelatrophie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE301191T1 true ATE301191T1 (de) | 2005-08-15 |
Family
ID=8218049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95402335T ATE301191T1 (de) | 1994-10-19 | 1995-10-19 | Motorneuronlebenserhaltungsgen: ein gen für spinale muskelatrophie |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US6080577A (de) |
| EP (1) | EP0708178A1 (de) |
| JP (2) | JP4283345B2 (de) |
| AT (1) | ATE301191T1 (de) |
| AU (1) | AU702252B2 (de) |
| CA (1) | CA2160937C (de) |
| DE (1) | DE69534351T2 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0708178A1 (de) * | 1994-10-19 | 1996-04-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Motoneuronlebenserhaltungsgen: ein Gen für spinale Muskelatrophie |
| US5792833A (en) * | 1994-12-22 | 1998-08-11 | New England Medical Center Hospitals, Inc. | E2 binding proteins |
| US6130064A (en) * | 1998-02-24 | 2000-10-10 | Incyte Pharmaceuticals, Inc. | Human SMN-like protein |
| EP1082433A4 (de) * | 1998-05-29 | 2003-01-02 | Human Genome Sciences Inc | Interleukine 21 und 22 |
| EP0999270A1 (de) * | 1998-10-09 | 2000-05-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Verfahren zur Regulierung der SMN-Genexpression |
| US20060088842A1 (en) * | 2004-02-13 | 2006-04-27 | Khue Vu Nguyen | RT-PCR-based cloning of human SMN, the SMA determining gene, and the construction of its expression plasmids |
| TW200613562A (en) * | 2004-10-26 | 2006-05-01 | Yi-Ning Su | Methods for smn genes and spinal muscular atrophy carriers detection |
| WO2006119295A2 (en) * | 2005-05-02 | 2006-11-09 | Combinatorx, Incorporated | Compositions and methods for the treatment of neurodegenerative diseases |
| US20090011004A1 (en) * | 2005-12-30 | 2009-01-08 | Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine | Improved carriers for delivery of nucleic acid agents to cells and tissues |
| JP5879256B2 (ja) | 2009-05-02 | 2016-03-08 | ジェンザイム・コーポレーション | 神経変性障害のための遺伝子治療 |
| CN106983768B (zh) * | 2009-06-17 | 2023-04-07 | 冷泉港实验室 | 用于在对象中调节smn2剪接的组合物和方法 |
| WO2011032109A1 (en) * | 2009-09-11 | 2011-03-17 | Sma Foundation | Biomarkers for spinal muscular atrophy |
| US9920317B2 (en) | 2010-11-12 | 2018-03-20 | The General Hospital Corporation | Polycomb-associated non-coding RNAs |
| JP6336755B2 (ja) | 2010-11-12 | 2018-06-06 | ザ ジェネラル ホスピタル コーポレイション | ポリコームに関連する非コードｒｎａ |
| US9994898B2 (en) | 2011-06-07 | 2018-06-12 | Icahn School Of Medicine At Mount Sinai | Materials and methods for identifying spinal muscular atrophy carriers |
| US10837014B2 (en) | 2012-05-16 | 2020-11-17 | Translate Bio Ma, Inc. | Compositions and methods for modulating SMN gene family expression |
| CA2873779A1 (en) | 2012-05-16 | 2013-11-21 | Rana Therapeutics Inc. | Compositions and methods for modulating mecp2 expression |
| EA201492123A1 (ru) | 2012-05-16 | 2015-10-30 | Рана Терапьютикс, Инк. | Композиции и способы для модулирования экспрессии семейства генов smn |
| EP3560502A1 (de) | 2013-04-12 | 2019-10-30 | The Curators of the University of Missouri | Smn2-element-1-antisense-zusammensetzungen sowie verfahren dafür und verwendungen davon |
| WO2015023941A1 (en) | 2013-08-16 | 2015-02-19 | Rana Therapeutics, Inc. | Oligonucleotides targeting euchromatin regions of genes |
| JP2016534035A (ja) | 2013-10-04 | 2016-11-04 | ラナ セラピューティクス インコーポレイテッド | 筋萎縮性側索硬化症を治療するための組成物及び方法 |
| BR112016008832A2 (pt) * | 2013-10-22 | 2017-10-03 | Shire Human Genetic Therapies | Distribuição de mrna no snc e suas utilizações |
| WO2016040748A1 (en) | 2014-09-12 | 2016-03-17 | Ionis Pharmaceuticals, Inc. | Compositions and methods for detection of smn protein in a subject and treatment of a subject |
| WO2016070060A1 (en) | 2014-10-30 | 2016-05-06 | The General Hospital Corporation | Methods for modulating atrx-dependent gene repression |
| US10900036B2 (en) | 2015-03-17 | 2021-01-26 | The General Hospital Corporation | RNA interactome of polycomb repressive complex 1 (PRC1) |
| CA3173034A1 (en) | 2020-02-28 | 2021-09-02 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating smn2 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| AU8196791A (en) * | 1990-06-27 | 1992-01-23 | Trustees Of Columbia University In The City Of New York, The | Methods for detecting spinal muscular atrophy type i and types ii/iii and marker therefor |
| EP0708178A1 (de) * | 1994-10-19 | 1996-04-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Motoneuronlebenserhaltungsgen: ein Gen für spinale Muskelatrophie |
| US5792833A (en) * | 1994-12-22 | 1998-08-11 | New England Medical Center Hospitals, Inc. | E2 binding proteins |
-
1994
- 1994-10-19 EP EP94402353A patent/EP0708178A1/de not_active Withdrawn
-
1995
- 1995-10-19 US US08/545,196 patent/US6080577A/en not_active Expired - Lifetime
- 1995-10-19 CA CA002160937A patent/CA2160937C/en not_active Expired - Lifetime
- 1995-10-19 AT AT95402335T patent/ATE301191T1/de not_active IP Right Cessation
- 1995-10-19 JP JP30634995A patent/JP4283345B2/ja not_active Expired - Lifetime
- 1995-10-19 DE DE69534351T patent/DE69534351T2/de not_active Expired - Lifetime
- 1995-10-19 AU AU34369/95A patent/AU702252B2/en not_active Expired
-
1998
- 1998-07-02 US US09/109,082 patent/US7033752B1/en not_active Expired - Fee Related
-
2005
- 2005-09-12 US US11/222,810 patent/US20060089490A1/en not_active Abandoned
-
2006
- 2006-11-22 US US11/603,305 patent/US20070166737A1/en not_active Abandoned
-
2007
- 2007-10-18 JP JP2007271610A patent/JP4723550B2/ja not_active Expired - Fee Related
-
2011
- 2011-04-28 US US13/096,574 patent/US8394932B2/en not_active Expired - Lifetime
-
2013
- 2013-02-04 US US13/758,754 patent/US8962269B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4283345B2 (ja) | 2009-06-24 |
| US6080577A (en) | 2000-06-27 |
| CA2160937C (en) | 2010-02-02 |
| US8394932B2 (en) | 2013-03-12 |
| JPH08228785A (ja) | 1996-09-10 |
| JP2008099696A (ja) | 2008-05-01 |
| AU702252B2 (en) | 1999-02-18 |
| EP0708178A1 (de) | 1996-04-24 |
| DE69534351D1 (de) | 2005-09-08 |
| AU3436995A (en) | 1996-05-02 |
| US20060089490A1 (en) | 2006-04-27 |
| US7033752B1 (en) | 2006-04-25 |
| JP4723550B2 (ja) | 2011-07-13 |
| DE69534351T2 (de) | 2006-06-08 |
| US20130323759A1 (en) | 2013-12-05 |
| CA2160937A1 (en) | 1996-04-20 |
| US8962269B2 (en) | 2015-02-24 |
| US20110294226A1 (en) | 2011-12-01 |
| US20070166737A1 (en) | 2007-07-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE301191T1 (de) | Motorneuronlebenserhaltungsgen: ein gen für spinale muskelatrophie | |
| Mössner et al. | Characterization of Escherichia coli thioredoxin variants mimicking the active‐sites of other thiol/disulfide oxidoreductases | |
| Wunderlich et al. | Redox properties of protein disulfide isomerase (DsbA) from Escherichia coli | |
| HUT72189A (en) | Rapamycin effector proteins, dna molecules which encode proteins, anti-sense dna molecules which hibridize with dna molecules, processes for isolating rapamycin effector proteins, for identifying immunomodulators, for detecting rapamycin analogs and ... | |
| EP0796913A3 (de) | GDP-Dissoziation stimulierendes Protein, gehirnspezifisches Nucleosomfügungsprotein, Skelettmuskel-spezifisches Ubiquitin-Conjugationsenzym, Zellproliferationsprotein, Phosphatidylinositolkinase, Nel verwandte Proteine | |
| ATE496134T1 (de) | Multigene vectoren und methoden für eine erhöhte expression von rekombinanten polypeptiden | |
| EP1361229A3 (de) | Verwendung von Tyrosine Kinase (PYK2) zur Produktion von Antikörper | |
| FI962247A (fi) | Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden käyttömenetelmät | |
| Brisson et al. | Interaction of tropomyosin and troponin T: a proton nuclear magnetic resonance study | |
| WO2003093316A3 (en) | Immunoglobulin-domain containing cell surface recognition molecules | |
| AU2191597A (en) | Vmp-like sequences of pathogenic borrelia | |
| CA2344590A1 (en) | Treatment of inflammatory disease | |
| DE69434844D1 (de) | Geneexpression der neurofilamentproteine und nachweis der alzheimeschen erkrankung | |
| Nagpal et al. | Plasticity in structure and interactions is critical for the action of indolicidin, an antibacterial peptide of innate immune origin | |
| EP0192175A3 (de) | Polypeptide des Rhinovirusstammes HRV2 sowie die hierfür codierenden DNA-Moleküle | |
| EP0773290A3 (de) | Proteinanaloge des LDL-Rezeptors und deren kodierende Gene | |
| WO1996021020A3 (en) | Borna disease viral sequences, diagnostics and therapeutics for nervous system diseases | |
| Weiss et al. | The SRY cantilever motif discriminates between sequence-and structure-specific DNA recognition: alanine mutagenesis of an HMG box | |
| EP1964921A3 (de) | Das Gen für hohe Knochenmasse 11q13.3 | |
| EP1693456A4 (de) | Für einen g-protein-gekoppelten rezeptor codierendes gen und dessen genprodukt | |
| WO2001049714A3 (en) | Nope polypeptides, encoding nucleic acids and methods of use | |
| DE69330966D1 (de) | DNA-Sequenzen des Epstein-Barr Virus kodierend für ein diagnostisch relevantes Virus-Hüllprotein, durch PCR erhaltene Expressionsklone und Verwendung dieses rekombinanten Antigens in diagnostischen Tests | |
| WO2003042366A3 (en) | A novel saitohin gene and uses of same | |
| EP1634951A4 (de) | Neues protein | |
| WO2005038463A8 (en) | Method for the detection of a neurological or psychiatric, demential disease, especially alzheimer's disease by use of cholecystokinin (cck) -molecules, corresponding substances and detection reagents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |