ATE29882T1 - Verfahren zur herstellung von substituierten pyrimidinonen und deren zwischenprodukte. - Google Patents
Verfahren zur herstellung von substituierten pyrimidinonen und deren zwischenprodukte.Info
- Publication number
- ATE29882T1 ATE29882T1 AT82300562T AT82300562T ATE29882T1 AT E29882 T1 ATE29882 T1 AT E29882T1 AT 82300562 T AT82300562 T AT 82300562T AT 82300562 T AT82300562 T AT 82300562T AT E29882 T1 ATE29882 T1 AT E29882T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimidinones
- substitute
- preparation
- intermediate products
- pyrimidine
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 1
- BBZZGDLNBVRFFI-UHFFFAOYSA-N 4,5-dihydropyrimidine Chemical compound C1CN=CN=C1 BBZZGDLNBVRFFI-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- -1 hydroxy, mercapto Chemical group 0.000 abstract 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/232,105 US4352933A (en) | 1981-02-06 | 1981-02-06 | Chemical methods and intermediates for preparing substituted pyrimidinones |
| EP82300562A EP0058055B1 (en) | 1981-02-06 | 1982-02-04 | Process for preparing substituted pyrimidinones and intermediates therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE29882T1 true ATE29882T1 (de) | 1987-10-15 |
Family
ID=22871897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82300562T ATE29882T1 (de) | 1981-02-06 | 1982-02-04 | Verfahren zur herstellung von substituierten pyrimidinonen und deren zwischenprodukte. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4352933A (forum.php) |
| EP (2) | EP0141973A3 (forum.php) |
| JP (1) | JPS57163378A (forum.php) |
| KR (1) | KR880001473B1 (forum.php) |
| AT (1) | ATE29882T1 (forum.php) |
| DE (1) | DE3277373D1 (forum.php) |
| DK (1) | DK49782A (forum.php) |
| ES (1) | ES8302723A1 (forum.php) |
| GR (1) | GR75406B (forum.php) |
| IE (1) | IE53005B1 (forum.php) |
| IL (1) | IL64621A (forum.php) |
| PT (1) | PT74293B (forum.php) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675406A (en) * | 1981-02-06 | 1987-06-23 | Smithkline Beckman Corporation | Substituted pyrimidinones |
| US4477663A (en) * | 1981-02-06 | 1984-10-16 | Smithkline Beckman Corporation | Intermediates for preparing substituted pyrimidinones |
| US4620001A (en) * | 1981-02-06 | 1986-10-28 | Smithkline Beckman Corporation | Chemical methods and intermediates for preparing substituted pyrimidinones |
| DK230482A (da) * | 1981-05-30 | 1982-12-01 | Smith Kline French Lab | Pyrimidonsalt og fremstilling heraf |
| DE3365869D1 (en) * | 1982-07-30 | 1986-10-09 | Smith Kline French Lab | Amino pyrimidinones and their preparation |
| US4772704A (en) * | 1983-09-21 | 1988-09-20 | Bristol-Myers Company | 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity |
| JP2807577B2 (ja) * | 1990-06-15 | 1998-10-08 | エーザイ株式会社 | 環状アミド誘導体 |
| DE69816471T2 (de) | 1997-11-06 | 2004-05-27 | Smithkline Beecham P.L.C., Brentford | Pyrimidinon verbindungen und diese enthaltende pharmazeutische zusammenstellungen |
| EP2382865A1 (de) | 2010-04-28 | 2011-11-02 | Bayer CropScience AG | Synergistische Wirkstoffkombinationen |
| WO2014035469A1 (en) | 2012-08-31 | 2014-03-06 | Bayer Cropscience Lp | Combinations and methods for controlling turfgrass pests |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
| US4153793A (en) * | 1973-05-03 | 1979-05-08 | Smith Kline & French Laboratories Limited | Imidazo alkylamino pyrimidones |
| US4145546A (en) * | 1975-10-02 | 1979-03-20 | Smith Kline & French Laboratories Limited | 4-Pyrimidone compounds |
| US4216318A (en) * | 1975-12-29 | 1980-08-05 | Smith Kline & French Laboratories Limited | Heterocyclic alkyl 4-pyrimidones |
| US4154834A (en) * | 1975-12-29 | 1979-05-15 | Smith Kline & French Laboratories Limited | Substituted isocytosines having histamine H2 -antagonist activity |
| GB1582528A (en) * | 1977-03-25 | 1981-01-07 | Smith Kline French Lab | Amino pyrimidone derivatives |
| IN151188B (forum.php) * | 1978-02-13 | 1983-03-05 | Smith Kline French Lab | |
| AU527202B2 (en) * | 1978-04-11 | 1983-02-24 | Smith Kline & French Laboratories Limited | 2-aminopyrimidones |
| ZA793443B (en) * | 1978-07-26 | 1980-12-31 | Glaxo Group Ltd | Heterocyclic derivatives |
| US4374836A (en) * | 1978-10-16 | 1983-02-22 | Imperial Chemical Industries Ltd. | Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them |
| EP0017675B1 (en) * | 1979-04-11 | 1982-04-28 | Hoogovens Groep B.V. | Expandable coiler mandrel |
| CA1140129A (en) * | 1979-08-21 | 1983-01-25 | Ronald J. King | 4-pyrimidone derivatives |
-
1981
- 1981-02-06 US US06/232,105 patent/US4352933A/en not_active Expired - Fee Related
- 1981-12-22 IL IL64621A patent/IL64621A/xx unknown
-
1982
- 1982-01-15 PT PT74293A patent/PT74293B/pt unknown
- 1982-02-03 ES ES509274A patent/ES8302723A1/es not_active Expired
- 1982-02-04 EP EP84111114A patent/EP0141973A3/en not_active Ceased
- 1982-02-04 DE DE8282300562T patent/DE3277373D1/de not_active Expired
- 1982-02-04 EP EP82300562A patent/EP0058055B1/en not_active Expired
- 1982-02-04 AT AT82300562T patent/ATE29882T1/de not_active IP Right Cessation
- 1982-02-05 DK DK49782A patent/DK49782A/da not_active Application Discontinuation
- 1982-02-05 GR GR67224A patent/GR75406B/el unknown
- 1982-02-05 JP JP57018094A patent/JPS57163378A/ja active Pending
- 1982-02-06 KR KR8200509A patent/KR880001473B1/ko not_active Expired
- 1982-02-08 IE IE270/82A patent/IE53005B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0058055B1 (en) | 1987-09-23 |
| PT74293B (pt) | 1983-06-28 |
| IE53005B1 (en) | 1988-05-11 |
| DK49782A (da) | 1982-08-07 |
| IE820270L (en) | 1982-08-06 |
| EP0058055A2 (en) | 1982-08-18 |
| US4352933A (en) | 1982-10-05 |
| ES509274A0 (es) | 1983-01-16 |
| DE3277373D1 (en) | 1987-10-29 |
| EP0141973A2 (en) | 1985-05-22 |
| KR830009088A (ko) | 1983-12-17 |
| IL64621A (en) | 1985-10-31 |
| IL64621A0 (en) | 1982-03-31 |
| ES8302723A1 (es) | 1983-01-16 |
| EP0058055A3 (en) | 1982-10-27 |
| EP0141973A3 (en) | 1986-02-26 |
| PT74293A (en) | 1982-02-01 |
| KR880001473B1 (ko) | 1988-08-13 |
| GR75406B (forum.php) | 1984-07-13 |
| JPS57163378A (en) | 1982-10-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU3811689A (en) | Alpha-arylacrylates substituted by a heterocyclic radical, and fungicides which contain these compounds | |
| ES8706146A1 (es) | Un procedimiento para preparar derivados de piridina | |
| KR830005216A (ko) | 이미다조[4,5-b] 피리딘 유도체의 제조방법 | |
| ATE29882T1 (de) | Verfahren zur herstellung von substituierten pyrimidinonen und deren zwischenprodukte. | |
| IE32035B1 (en) | Improved process for making 1,4,5,6-tetrahydro-2-((2-substituted)vinyl)pyrimidines and 2-((2-substituted)vinyl)-2-imidazolines | |
| SE7910376L (sv) | Kinazolinonderivat | |
| ATE51870T1 (de) | Beta-lactamantibiotika, verfahren zu deren herstellung sowie ihre verwendung als arzneimittel oder wachstumsfoerderer in der tieraufzucht oder als antioxidantien. | |
| KR870006082A (ko) | 10β-알키닐에스트렌 유도체의 제조방법 | |
| DE3567658D1 (de) | (1,2,4-triazolyl-1-yl)-methyl carbinols | |
| DE3587112D1 (de) | 2-quaternaer-pyridinalkylthio- oder -pyridinalkenylthiosubstituierte carbapeneme, diese enthaltende zusammensetzungen und ihre zusammenstellungen mit dhp-inhibitoren. | |
| IL67286A (en) | Urea derivatives,their manufacture and their use as herbicides | |
| DE3582890D1 (de) | 2-oxindolzwischenprodukte. | |
| UA8032A1 (uk) | Спосіб одержання 2-(4-метоксіфенілпропіоніл)аміно-6-н-пропіламіно-4,5,6,7-тетрагідробензотіазола у вигляді рацемата або (-)-енантіомера або його кислотно-аддітивної солі | |
| KR840008359A (ko) | 니플룸산 모르폴리노에틸 에스테르 디니플루메이트의 제조방법 | |
| HUT37863A (en) | Fungicides and process for production of the beta naftil-alkyl-amin derivatives that can be applied as reagent | |
| ATE78473T1 (de) | Verfahren zur herstellung von 2,4-diamino-6-(1piperidinyl)-pyramidin-n-oxid. | |
| GB1185039A (en) | Pyrimidine Derivatives and Compositions containing them | |
| AU6653190A (en) | Fungicides | |
| ATE14125T1 (de) | 5-(4-phenyl-1-piperidinyl)methyl-2,3-dihydro-2oxo-1h-imidazol-4-carbonsaeure-derivate. | |
| DK159432C (da) | Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater | |
| SE8101841L (sv) | Imidazo (4,5-b)-pyridinderivat anvendbara sasom kardiotonika samt framstellning derav | |
| SU1496220A1 (ru) | Трис(2-гидроксиэтил)аммониевые соли гетерилтиоуксусных кислот, обладающие гиполипидемическим действием | |
| KR830001931A (ko) | 히스타민 길항체의 제조방법 | |
| ATE67188T1 (de) | Verfahren zur stabilisierung von procaterol. | |
| EP0358081A3 (de) | Verfahren zur Herstellung von 2-n-Propyl-4-amino-5-methoxymethyl-pyrimidin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |