ATE297412T1 - Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung - Google Patents
Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierungInfo
- Publication number
- ATE297412T1 ATE297412T1 AT97936042T AT97936042T ATE297412T1 AT E297412 T1 ATE297412 T1 AT E297412T1 AT 97936042 T AT97936042 T AT 97936042T AT 97936042 T AT97936042 T AT 97936042T AT E297412 T1 ATE297412 T1 AT E297412T1
- Authority
- AT
- Austria
- Prior art keywords
- dermatan
- complement activation
- thrombin generation
- disulphate
- inhibitor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Surgery (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/795,099 US5922690A (en) | 1996-04-25 | 1997-02-06 | Dermatan disulfate, an inhibitor of thrombin generation and activation |
PCT/US1997/011750 WO1998034959A1 (en) | 1997-02-06 | 1997-07-03 | Dermatan disulfate, an inhibitor of thrombin generation and complement activation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE297412T1 true ATE297412T1 (de) | 2005-06-15 |
Family
ID=25164665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97936042T ATE297412T1 (de) | 1997-02-06 | 1997-07-03 | Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung |
Country Status (10)
Country | Link |
---|---|
US (1) | US5922690A (de) |
EP (1) | EP0983304B1 (de) |
JP (1) | JP2003512807A (de) |
AT (1) | ATE297412T1 (de) |
AU (1) | AU734112C (de) |
CA (1) | CA2279535C (de) |
DE (1) | DE69733493T2 (de) |
ES (1) | ES2242980T3 (de) |
PT (1) | PT983304E (de) |
WO (1) | WO1998034959A1 (de) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9711443D0 (en) * | 1997-06-03 | 1997-07-30 | Leo Pharm Prod Ltd | Chemical suppositions |
IL127826A0 (en) * | 1998-12-29 | 1999-10-28 | Laster Gail | Restenosis drug therapy |
DE19913707A1 (de) | 1999-03-26 | 2000-10-05 | Privates Inst Bioserv Gmbh | Immunadsorber zur Sepsistherapie |
US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
KR20020032444A (ko) * | 1999-06-30 | 2002-05-03 | 잭 허쉬 | 응괴 연관된 응고 인자를 억제하는 헤파린 조성물 |
US6518244B2 (en) * | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
JP2002080371A (ja) * | 2000-06-23 | 2002-03-19 | Seikagaku Kogyo Co Ltd | プラスミノーゲンアクチベーター活性促進剤 |
PL363047A1 (en) * | 2000-09-08 | 2004-11-15 | Hamilton Civic Hospitals Research Development Inc. | Antithrombotic compositions |
AU2002243630A1 (en) | 2001-01-23 | 2002-08-06 | Massachusetts Institute Of Technology | Solid- and solution -phase synthesis of heparin and other glycosaminoglycans |
JP4915888B2 (ja) * | 2001-08-01 | 2012-04-11 | 株式会社ジャパンエコロジーシンキング | 豚皮抽出物よりのデルマタン硫酸の製造方法 |
DE10307205A1 (de) * | 2003-02-20 | 2004-09-09 | Jostra Ag | Blutverträgliche Beschichtung von Kunststoffoberflächen |
US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
US20090105463A1 (en) * | 2005-03-29 | 2009-04-23 | Massachusetts Institute Of Technology | Compositions of and Methods of Using Oversulfated Glycosaminoglycans |
US9114194B2 (en) * | 2006-05-12 | 2015-08-25 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having high biological activity following mechanical manipulation |
US20080279909A1 (en) * | 2006-05-12 | 2008-11-13 | Cleek Robert L | Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization |
US8496953B2 (en) * | 2006-05-12 | 2013-07-30 | W. L. Gore & Associates, Inc. | Immobilized biologically active entities having a high degree of biological activity following sterilization |
US8986713B2 (en) * | 2006-05-12 | 2015-03-24 | W. L. Gore & Associates, Inc. | Medical device capable of being compacted and expanded having anti-thrombin III binding activity |
US8021677B2 (en) | 2006-05-12 | 2011-09-20 | Gore Enterprise Holdings, Inc. | Immobilized biologically active entities having a high degree of biological activity |
US8703136B2 (en) | 2006-10-10 | 2014-04-22 | Regenesance B.V. | Complement inhibition for improved nerve regeneration |
US8617820B2 (en) * | 2007-08-28 | 2013-12-31 | Ortho-Clinical Diagnostics, Inc. | Use of glycosaminoglycans to reduce non-specific binding in immunoassays |
DE102008045127A1 (de) | 2008-09-01 | 2010-03-04 | Heinrich, Hans-Werner, Prof. Dr. | Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs) |
US8591932B2 (en) * | 2009-09-17 | 2013-11-26 | W. L. Gore & Associates, Inc. | Heparin entities and methods of use |
EP3375462B1 (de) | 2011-03-11 | 2023-06-07 | W. L. Gore & Associates, Inc. | Verbesserungen an immobilisierten biologischen einheiten |
WO2013006906A1 (en) * | 2011-07-11 | 2013-01-17 | Commonwealth Scientific And Industrial Research Organisation | Dermatan sulphate, pharmaceutical compositions and process for producing same |
CN106188341B (zh) * | 2016-07-27 | 2019-09-17 | 河北常山生化药业股份有限公司 | 肝素钠下脚料制备高纯度硫酸皮肤素工艺 |
CN106146688A (zh) * | 2016-07-27 | 2016-11-23 | 河北常山生化药业股份有限公司 | 肝素钠下脚料制备类肝素工艺 |
WO2021107067A1 (ja) * | 2019-11-29 | 2021-06-03 | マルホ株式会社 | 医薬品または化粧品用組成物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA795325A (en) * | 1962-08-06 | 1968-09-24 | Roussel-Uclaf | Procede de preparation de nouveaux derives de l'heparine |
SE306597B (de) * | 1964-12-17 | 1968-12-02 | Incentive Ab | |
FR2482603A1 (fr) * | 1980-05-14 | 1981-11-20 | Pharmindustrie | Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation |
DE3124384C2 (de) * | 1981-06-22 | 1985-05-15 | Herbert Prof. Dr. 1000 Berlin Voß | Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel |
FR2538404B1 (de) * | 1982-12-28 | 1985-08-23 | Anic Spa | |
FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
US4745106A (en) * | 1986-08-20 | 1988-05-17 | Griffin Charles C | Heparin derivatives having improved anti-Xa specificity |
CA2000650A1 (en) * | 1989-10-13 | 1991-04-13 | Louis Jaques | Product and process for the treatment and prevention of intravascular thrombi and atherosclerosis |
US5362755A (en) * | 1990-01-05 | 1994-11-08 | Sepracor, Inc. | Method for treating asthma using optically pure (R)-albuterol |
JP2855307B2 (ja) * | 1992-02-05 | 1999-02-10 | 生化学工業株式会社 | 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法 |
-
1997
- 1997-02-06 US US08/795,099 patent/US5922690A/en not_active Expired - Lifetime
- 1997-07-03 JP JP53430498A patent/JP2003512807A/ja active Pending
- 1997-07-03 EP EP97936042A patent/EP0983304B1/de not_active Expired - Lifetime
- 1997-07-03 AT AT97936042T patent/ATE297412T1/de not_active IP Right Cessation
- 1997-07-03 AU AU38807/97A patent/AU734112C/en not_active Ceased
- 1997-07-03 CA CA002279535A patent/CA2279535C/en not_active Expired - Lifetime
- 1997-07-03 DE DE69733493T patent/DE69733493T2/de not_active Expired - Fee Related
- 1997-07-03 PT PT97936042T patent/PT983304E/pt unknown
- 1997-07-03 ES ES97936042T patent/ES2242980T3/es not_active Expired - Lifetime
- 1997-07-03 WO PCT/US1997/011750 patent/WO1998034959A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU734112C (en) | 2002-03-28 |
WO1998034959A1 (en) | 1998-08-13 |
EP0983304B1 (de) | 2005-06-08 |
AU3880797A (en) | 1998-08-26 |
ES2242980T3 (es) | 2005-11-16 |
AU734112B2 (en) | 2001-06-07 |
JP2003512807A (ja) | 2003-04-02 |
CA2279535C (en) | 2006-10-03 |
US5922690A (en) | 1999-07-13 |
DE69733493T2 (de) | 2006-03-23 |
CA2279535A1 (en) | 1998-08-13 |
DE69733493D1 (de) | 2005-07-14 |
EP0983304A1 (de) | 2000-03-08 |
PT983304E (pt) | 2005-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0983304 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |