ATE296633T1 - Thiopyran-4-one als inhibitoren der dna protein kinase - Google Patents

Thiopyran-4-one als inhibitoren der dna protein kinase

Info

Publication number
ATE296633T1
ATE296633T1 AT02751427T AT02751427T ATE296633T1 AT E296633 T1 ATE296633 T1 AT E296633T1 AT 02751427 T AT02751427 T AT 02751427T AT 02751427 T AT02751427 T AT 02751427T AT E296633 T1 ATE296633 T1 AT E296633T1
Authority
AT
Austria
Prior art keywords
sub
sup
thiopyran
inhibitors
protein kinase
Prior art date
Application number
AT02751427T
Other languages
German (de)
English (en)
Inventor
Roger John Griffin
Bernard Thomas Golding
David Richard Newell
Hilary Alan Calvert
Nicola Jane Curtin
Ian Robert Hardcastle
Niall Martin
Graeme Cameron Smith
Laurent Jean Martin Rigoreau
Paul Workman
Florence Irene Raynaud
Bernard Paul Nutley
Original Assignee
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd
Application granted granted Critical
Publication of ATE296633T1 publication Critical patent/ATE296633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
AT02751427T 2001-08-14 2002-08-14 Thiopyran-4-one als inhibitoren der dna protein kinase ATE296633T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0119863.9A GB0119863D0 (en) 2001-08-14 2001-08-14 DNA-PK inhibitors
PCT/GB2002/003740 WO2003015790A1 (en) 2001-08-14 2002-08-14 Thiopyrane-4-ones as dna protein kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE296633T1 true ATE296633T1 (de) 2005-06-15

Family

ID=9920418

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02751427T ATE296633T1 (de) 2001-08-14 2002-08-14 Thiopyran-4-one als inhibitoren der dna protein kinase

Country Status (8)

Country Link
US (1) US7105518B2 (enExample)
EP (1) EP1416936B1 (enExample)
JP (1) JP4299666B2 (enExample)
AT (1) ATE296633T1 (enExample)
DE (1) DE60204468T2 (enExample)
ES (1) ES2243750T3 (enExample)
GB (1) GB0119863D0 (enExample)
WO (1) WO2003015790A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0209891D0 (en) * 2002-04-30 2002-06-05 Glaxo Group Ltd Novel compounds
WO2005016919A1 (en) * 2003-08-13 2005-02-24 Kudos Pharmaceuticals Limited Aminopyrones and their use as atm inhibitors
JP2008513428A (ja) * 2004-09-20 2008-05-01 クドス ファーマシューティカルズ リミテッド Ｄｎａ−ｐｋ阻害剤
CN101115747A (zh) * 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
WO2006126010A2 (en) * 2005-05-26 2006-11-30 Kudos Pharmaceuticals Limited Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
BR112021022536A2 (pt) * 2019-05-10 2021-12-28 Shanghai Haiyan Pharmaceutical Tech Co Ltd Derivado de fenilpropenilpiridina substituída e método de preparação do mesmo e uso médico do mesmo

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* Cited by examiner, † Cited by third party
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GB1303724A (enExample) 1969-05-14 1973-01-17
JPH0753725B2 (ja) 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US5284856A (en) 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
FI912995A7 (fi) 1988-12-21 1991-06-19 Upjohn Co Antiateroskleroottisia ja antitromboottisia 1-bentsopyran-4-oneja ja 2 -amino-1,3-bentsoksatsin-4-oneja
US5703075A (en) 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
JPH03215423A (ja) 1990-01-18 1991-09-20 Kyowa Hakko Kogyo Co Ltd 血管拡張剤
ES2106783T3 (es) 1990-06-20 1997-11-16 Upjohn Co 1-benzopiran-4-onas y 2-amino-1,3-benzoxacin-4-onas antiarterosclerosis y antitromboticas.
US5302613A (en) 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
WO1992000290A1 (en) 1990-06-29 1992-01-09 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4h-pyran-4-ones
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JP3215423B2 (ja) 1992-01-18 2001-10-09 ザ・ユニバーシティ・オブ・ニューキャッスル・アポン・タイン 導電性ポリマーの製法
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US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
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US6632789B1 (en) 1994-04-29 2003-10-14 The United States Of America As Represented By The Secretary Of The Navy Methods for modulating T cell responses by manipulating intracellular signal transduction
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IL121306A0 (en) 1995-11-16 1998-01-04 Icos Corp Cell cycle checkpoint pik-related kinase materials and methods
GB2302021A (en) 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption
EP0990028A4 (en) 1997-06-06 2000-09-27 Mayo Foundation For Medical SCREENING OF PHOSPHATIDILYNOSITOL-LINKED KINASE INHIBITORS
AU8068198A (en) 1997-06-13 1998-12-30 President And Fellows Of Harvard College Methods for treating human cancers
FR2776291B1 (fr) 1998-03-18 2000-06-16 Pf Medicament Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6348311B1 (en) 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
DE60128655T2 (de) 2000-01-24 2008-02-07 Astrazeneca Ab Durch einen morpholinrest substituierte therapeutische verbindungen
WO2002020500A2 (en) 2000-09-01 2002-03-14 Icos Corporation Materials and methods to potentiate cancer treatment
DE60203260T2 (de) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
AU2002349912A1 (en) 2001-10-24 2003-05-06 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
WO2003034997A2 (en) 2001-10-24 2003-05-01 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
CN100358891C (zh) 2002-02-25 2008-01-02 库多斯药物有限公司 可用作atm抑制剂的吡喃酮
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
ES2357057T3 (es) 2002-04-30 2011-04-15 Kudos Pharmaceuticals Limited Derivados de ftalazinona.

Also Published As

Publication number Publication date
DE60204468D1 (de) 2005-07-07
DE60204468T2 (de) 2006-04-27
WO2003015790A1 (en) 2003-02-27
US20050107367A1 (en) 2005-05-19
JP4299666B2 (ja) 2009-07-22
EP1416936B1 (en) 2005-06-01
ES2243750T3 (es) 2005-12-01
US7105518B2 (en) 2006-09-12
JP2005502656A (ja) 2005-01-27
EP1416936A1 (en) 2004-05-12
GB0119863D0 (en) 2001-10-10

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