ATE291096T1 - Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen - Google Patents

Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen

Info

Publication number
ATE291096T1
ATE291096T1 AT00950764T AT00950764T ATE291096T1 AT E291096 T1 ATE291096 T1 AT E291096T1 AT 00950764 T AT00950764 T AT 00950764T AT 00950764 T AT00950764 T AT 00950764T AT E291096 T1 ATE291096 T1 AT E291096T1
Authority
AT
Austria
Prior art keywords
lumi
hydrolytic enzymes
phosphatases
attached
hydrolytic
Prior art date
Application number
AT00950764T
Other languages
English (en)
Inventor
Qingping Jiang
Anand Natrajan
David J Sharpe
Wen-Jee Wong
Say-Jong Law
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE291096T1 publication Critical patent/ATE291096T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/64—Acridine or hydrogenated acridine ring systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT00950764T 1999-07-30 2000-07-27 Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen ATE291096T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14664899P 1999-07-30 1999-07-30
PCT/US2000/020429 WO2001009372A1 (en) 1999-07-30 2000-07-27 Chemiluminescent substrates of hydrolytic enzymes such as phosphatases

Publications (1)

Publication Number Publication Date
ATE291096T1 true ATE291096T1 (de) 2005-04-15

Family

ID=22518335

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00950764T ATE291096T1 (de) 1999-07-30 2000-07-27 Chemilumineszenz-substrate von hydrolytischen enzymen wie phosphatasen

Country Status (6)

Country Link
EP (1) EP1203091B1 (de)
JP (1) JP3819294B2 (de)
AT (1) ATE291096T1 (de)
AU (1) AU6381900A (de)
DE (1) DE60018758T2 (de)
WO (1) WO2001009372A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6783948B1 (en) 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
CA2448824A1 (en) * 2001-06-01 2002-12-12 F. Hoffmann-La Roche Ag Novel compounds for chemiluminescense procedures
US6664043B2 (en) * 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
US6723851B2 (en) * 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
GB0208987D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring protein kinase and phosphatase activity
ATE553089T1 (de) * 2002-08-20 2012-04-15 Quest Diagnostics Invest Inc Hydrophile, chemilumineszente acridiniummarkierungsreagenzien
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
US7319041B2 (en) * 2002-09-27 2008-01-15 Siemens Medical Solutions Diagnostic Applications of acridinium compounds and derivatives in homogeneous assays
FR2850378B1 (fr) * 2003-01-29 2005-03-04 Bio Merieux Substrats enzymatiques, milieux de culture les contenant, utilisation pour detecter une activite aminopeptidase et/ou differencier des bacteries a gram+ par rapport a des bacteries a gram-
CN103868913B (zh) * 2014-02-11 2017-07-14 中生北控生物科技股份有限公司 碱性磷酸酶的酶促化学发光底物液
CN110003106B (zh) * 2019-04-24 2020-11-06 郑州原理生物科技有限公司 一种吖啶的制备方法
CN114245830A (zh) * 2019-08-07 2022-03-25 深圳华大基因科技有限公司 含吖啶酯的化合物及将其用于基于化学发光的单色测序的方法
CN116789701A (zh) * 2023-05-30 2023-09-22 湖南超亟检测技术有限责任公司 一种检测碱性磷酸酯酶的近红外荧光分子探针及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4810636A (en) * 1986-12-09 1989-03-07 Miles Inc. Chromogenic acridinone enzyme substrates
US5656426A (en) * 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
CA2140661A1 (en) * 1992-07-20 1994-02-03 Sharat Singh Novel chemiluminescent compounds and methods of use
US5772926A (en) * 1997-05-13 1998-06-30 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
AU5473999A (en) * 1998-08-11 2000-03-06 Bayer Corporation Near infrared chemiluminescent acridinium compounds and uses thereof

Also Published As

Publication number Publication date
EP1203091B1 (de) 2005-03-16
JP3819294B2 (ja) 2006-09-06
DE60018758D1 (de) 2005-04-21
DE60018758T2 (de) 2006-01-19
JP2003528938A (ja) 2003-09-30
WO2001009372A1 (en) 2001-02-08
AU6381900A (en) 2001-02-19
EP1203091A1 (de) 2002-05-08
WO2001009372B1 (en) 2001-06-14

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