ATE289748T1 - Verwendung eines tiermodells, das p53-defizient ist und dessen erinnerungsvermögen und/oder verhalten gestört ist, zur entwicklung von therapeutika - Google Patents

Verwendung eines tiermodells, das p53-defizient ist und dessen erinnerungsvermögen und/oder verhalten gestört ist, zur entwicklung von therapeutika

Info

Publication number
ATE289748T1
ATE289748T1 AT99932972T AT99932972T ATE289748T1 AT E289748 T1 ATE289748 T1 AT E289748T1 AT 99932972 T AT99932972 T AT 99932972T AT 99932972 T AT99932972 T AT 99932972T AT E289748 T1 ATE289748 T1 AT E289748T1
Authority
AT
Austria
Prior art keywords
therapeutics
deficiency
behavior
development
animal model
Prior art date
Application number
AT99932972T
Other languages
English (en)
Inventor
Robert Amson
Jean-Michel Lassalle
Adam Telerman
Original Assignee
Molecular Engines Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Engines Lab filed Critical Molecular Engines Lab
Application granted granted Critical
Publication of ATE289748T1 publication Critical patent/ATE289748T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Generation (AREA)
  • Surgical Instruments (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99932972T 1998-08-05 1999-07-26 Verwendung eines tiermodells, das p53-defizient ist und dessen erinnerungsvermögen und/oder verhalten gestört ist, zur entwicklung von therapeutika ATE289748T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9810076A FR2781979B1 (fr) 1998-08-05 1998-08-05 Modele animal presentant une deficience de la memoire et/ou des troubles comportementaux
PCT/FR1999/001828 WO2000007438A1 (fr) 1998-08-05 1999-07-26 Utilisation d'un modele animal deficient en p53 et presentant une deficience de la memoire et/ou des troubles comportementaux a des fins therapeutiques

Publications (1)

Publication Number Publication Date
ATE289748T1 true ATE289748T1 (de) 2005-03-15

Family

ID=9529432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99932972T ATE289748T1 (de) 1998-08-05 1999-07-26 Verwendung eines tiermodells, das p53-defizient ist und dessen erinnerungsvermögen und/oder verhalten gestört ist, zur entwicklung von therapeutika

Country Status (8)

Country Link
US (1) US6921845B1 (de)
EP (1) EP1102530B1 (de)
JP (1) JP2002521073A (de)
AT (1) ATE289748T1 (de)
CA (1) CA2339876A1 (de)
DE (1) DE69923976T2 (de)
FR (1) FR2781979B1 (de)
WO (1) WO2000007438A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186879B2 (en) * 2000-09-21 2007-03-06 Baylor College Of Medicine Screening systems and methods for identifying modulators of xenobiotic metabolism
CA2422921A1 (en) * 2000-09-21 2002-03-28 David D. Moore Screening systems and methods for identifying modulators of xenobiotic metabolism
CA2465337A1 (en) * 2001-11-14 2003-05-22 Yamanouchi Pharmaceutical Co., Ltd. Transgenic animal
US7705198B2 (en) 2006-05-10 2010-04-27 Board Of Regents Of The University Of Nebraska KSR2 knockout mice and methods of use thereof
US7723564B2 (en) 2006-05-10 2010-05-25 Board Of Regents Of The University Of Nebraska Compositions and methods for modulation of KSR1 and KSR2 interactions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0565638A1 (de) * 1991-01-04 1993-10-20 Baylor College Of Medicine Tumoranfällige nicht-menschliche tiere
FR2710846B1 (fr) * 1993-10-04 1995-12-22 Rhone Poulenc Rorer Sa Compositions pharmaceutiques et leur utilisation, notamment dans le traitement des maladies neurogénératives.
US5659024A (en) * 1994-01-14 1997-08-19 The Burnham Institute Promotors that regulate the expression of genes involved in cell death

Also Published As

Publication number Publication date
DE69923976T2 (de) 2006-04-06
WO2000007438A1 (fr) 2000-02-17
CA2339876A1 (fr) 2000-02-17
FR2781979B1 (fr) 2001-06-08
JP2002521073A (ja) 2002-07-16
EP1102530B1 (de) 2005-03-02
US6921845B1 (en) 2005-07-26
FR2781979A1 (fr) 2000-02-11
DE69923976D1 (de) 2005-04-07
EP1102530A1 (de) 2001-05-30

Similar Documents

Publication Publication Date Title
Miner A Review of the Literature on the Nature and Control of Odors from Pork Production Facilities: Bibliography
DE69528888D1 (de) Regulierung von nf-kappa-b aktivität durch proteasome
LV12283A (lv) Naaladazes kompozicijas un to pielietojums dzivnieku glutamata vielmainas anomalijas arstesanai un neironu aktivitates ietekmesanai
Gadzama Attenuation of the effects of desertification through sustainable development of Great Green Wall in the Sahel of Africa
Round Feedback effects in interregional input-output models: What have we learned?
ATE289748T1 (de) Verwendung eines tiermodells, das p53-defizient ist und dessen erinnerungsvermögen und/oder verhalten gestört ist, zur entwicklung von therapeutika
DE69121113D1 (de) Verfahren zur bestimmung von benutzerschnittstellen und programmiersystem fur einen rechner mit mehreren benutzerschnittstellen
Gelbach The lifecycle welfare migration hypothesis: Evidence from the 1980 and 1990 censuses
Michelson Public policy in temporal perspective
DE69423979D1 (de) Verwendung von mindestens einem terpen und/oder seiner derivate als zusatz zu einem herbizidbrei oder coformulierungsmittel einer herbizidkomposition
DE69936779D1 (de) Verwendung von ngali nussöl zur behandlung/linderung der arthritisschmerzen und anderer ähnlichen störungen
Gade The influence of basic design variables on the acoustics of concert halls; new results derived from analysing a large number of existing halls
ATE342372T1 (de) Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln
Kondaparthi et al. Identification of Novel Molecular Scaffolds as Inhibitors of SP2 Protein-An Insilico Approach
Swallow Artificial selection for high voluntary activity in house mice: a study in evolutionary physiology
ATE349544T1 (de) Verfahren zur herstellung von d-pantothensäure und/oder deren salze als zusatz zu tierfuttermitteln
Kato et al. The Productivity Effects of Participatory Employment Practices: Evidence from New Japanese Panel Data
Konings et al. Union wage bargaining and European antidumping policy in imperfectly competitive markets
EP0919606A3 (de) Verfahren zur Behandlung von Kühlschmiermitteln gegen Mikroorganismen
DE69216236D1 (de) Mittel zur abwehr von tieren, verfahren zu ihrer herstellung und ihre verwendung
Lee et al. Effect of drinking and smoking on skin health and make-up
Dickinson Religious practices of adolescents in a southern community: 1964-1974
Pahuja et al. Samriddhii: A Case of Integrated Social Entrepreneurship in Bihar
DE60303296D1 (de) Verwendung von (3-(2-ethylphenyl)-5-methoxyphenyl)-1h-(1,2,4)-triazol zur behandung von autoimmunkrankheiten
Krishnamurthi Simulation of gravitational water movement in soil

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties