ATE289748T1 - USE OF AN ANIMAL MODEL THAT IS P53 DEFICIENCY AND HAS IMPROPER MEMORY AND/OR BEHAVIOR FOR THE DEVELOPMENT OF THERAPEUTICS - Google Patents

USE OF AN ANIMAL MODEL THAT IS P53 DEFICIENCY AND HAS IMPROPER MEMORY AND/OR BEHAVIOR FOR THE DEVELOPMENT OF THERAPEUTICS

Info

Publication number
ATE289748T1
ATE289748T1 AT99932972T AT99932972T ATE289748T1 AT E289748 T1 ATE289748 T1 AT E289748T1 AT 99932972 T AT99932972 T AT 99932972T AT 99932972 T AT99932972 T AT 99932972T AT E289748 T1 ATE289748 T1 AT E289748T1
Authority
AT
Austria
Prior art keywords
therapeutics
deficiency
behavior
development
animal model
Prior art date
Application number
AT99932972T
Other languages
German (de)
Inventor
Robert Amson
Jean-Michel Lassalle
Adam Telerman
Original Assignee
Molecular Engines Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Engines Lab filed Critical Molecular Engines Lab
Application granted granted Critical
Publication of ATE289748T1 publication Critical patent/ATE289748T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Image Generation (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Surgical Instruments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Mice that are deficient in p53 are found to have memory disorders and/or behavioral disorders such as increased anxiety. A method of using p53-deficient mice to screen compounds for memory restoring activity and/or anti-anxiety activity is described.
AT99932972T 1998-08-05 1999-07-26 USE OF AN ANIMAL MODEL THAT IS P53 DEFICIENCY AND HAS IMPROPER MEMORY AND/OR BEHAVIOR FOR THE DEVELOPMENT OF THERAPEUTICS ATE289748T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9810076A FR2781979B1 (en) 1998-08-05 1998-08-05 ANIMAL MODEL WITH DEFICIENCY OF MEMORY AND / OR BEHAVIORAL DISORDERS
PCT/FR1999/001828 WO2000007438A1 (en) 1998-08-05 1999-07-26 Use of an animal model deficient in p53 and having memory deficiency and/or behavioural disorders for therapeutic purposes

Publications (1)

Publication Number Publication Date
ATE289748T1 true ATE289748T1 (en) 2005-03-15

Family

ID=9529432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99932972T ATE289748T1 (en) 1998-08-05 1999-07-26 USE OF AN ANIMAL MODEL THAT IS P53 DEFICIENCY AND HAS IMPROPER MEMORY AND/OR BEHAVIOR FOR THE DEVELOPMENT OF THERAPEUTICS

Country Status (8)

Country Link
US (1) US6921845B1 (en)
EP (1) EP1102530B1 (en)
JP (1) JP2002521073A (en)
AT (1) ATE289748T1 (en)
CA (1) CA2339876A1 (en)
DE (1) DE69923976T2 (en)
FR (1) FR2781979B1 (en)
WO (1) WO2000007438A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186879B2 (en) * 2000-09-21 2007-03-06 Baylor College Of Medicine Screening systems and methods for identifying modulators of xenobiotic metabolism
AU2001291192B2 (en) * 2000-09-21 2006-11-30 Baylor College Of Medicine Screening systems and methods for identifying modulators of xenobiotic metabolism
WO2003041496A1 (en) * 2001-11-14 2003-05-22 Yamanouchi Pharmaceutical Co., Ltd. Transgenic animal
US7705198B2 (en) 2006-05-10 2010-04-27 Board Of Regents Of The University Of Nebraska KSR2 knockout mice and methods of use thereof
US7723564B2 (en) 2006-05-10 2010-05-25 Board Of Regents Of The University Of Nebraska Compositions and methods for modulation of KSR1 and KSR2 interactions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1236092A (en) * 1991-01-04 1992-08-17 Baylor College Of Medicine Tumor susceptible non-human animals
FR2710846B1 (en) * 1993-10-04 1995-12-22 Rhone Poulenc Rorer Sa Pharmaceutical compositions and their use, in particular in the treatment of neurogenerative diseases.
US5659024A (en) * 1994-01-14 1997-08-19 The Burnham Institute Promotors that regulate the expression of genes involved in cell death

Also Published As

Publication number Publication date
WO2000007438A1 (en) 2000-02-17
FR2781979B1 (en) 2001-06-08
FR2781979A1 (en) 2000-02-11
CA2339876A1 (en) 2000-02-17
EP1102530B1 (en) 2005-03-02
DE69923976D1 (en) 2005-04-07
EP1102530A1 (en) 2001-05-30
US6921845B1 (en) 2005-07-26
DE69923976T2 (en) 2006-04-06
JP2002521073A (en) 2002-07-16

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