ATE287893T1 - Zusamensetzungen mit schädlicher vasculärer wirkung - Google Patents
Zusamensetzungen mit schädlicher vasculärer wirkungInfo
- Publication number
- ATE287893T1 ATE287893T1 AT01955467T AT01955467T ATE287893T1 AT E287893 T1 ATE287893 T1 AT E287893T1 AT 01955467 T AT01955467 T AT 01955467T AT 01955467 T AT01955467 T AT 01955467T AT E287893 T1 ATE287893 T1 AT E287893T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- alkyl
- compound
- formula
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title 1
- 230000002792 vascular Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 150000001875 compounds Chemical class 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004414 alkyl thio group Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 101100243950 Arabidopsis thaliana PIE1 gene Proteins 0.000 abstract 1
- JHKPPUKSLOYWRN-UHFFFAOYSA-N N-hydrazinylnitramide Chemical compound NNN[N+]([O-])=O JHKPPUKSLOYWRN-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/30—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to nitro or nitroso groups
- C07C279/32—N-nitroguanidines
- C07C279/36—Substituted N-nitroguanidines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0019944.8A GB0019944D0 (en) | 2000-08-15 | 2000-08-15 | Compositions with vascular damaging activity |
| PCT/GB2001/003668 WO2002014329A1 (en) | 2000-08-15 | 2001-08-15 | Compositions with vascular damaging activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE287893T1 true ATE287893T1 (de) | 2005-02-15 |
Family
ID=9897553
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01955467T ATE287893T1 (de) | 2000-08-15 | 2001-08-15 | Zusamensetzungen mit schädlicher vasculärer wirkung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7105501B2 (de) |
| EP (1) | EP1311514B1 (de) |
| AT (1) | ATE287893T1 (de) |
| AU (1) | AU2001277629A1 (de) |
| DE (1) | DE60108647T2 (de) |
| GB (1) | GB0019944D0 (de) |
| PT (1) | PT1311514E (de) |
| WO (1) | WO2002014329A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6670344B2 (en) | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| US20050153939A1 (en) | 2003-09-10 | 2005-07-14 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono-and di-organic amine salts, mono-and di-amino acid salts, and mono-and di-amino acid ester salts |
| WO2003035008A2 (en) | 2001-10-26 | 2003-05-01 | Oxigene, Inc. | Functionalized stilbene derivatives as improved vascular targeting agents |
| EP1601348A4 (de) | 2003-02-28 | 2008-12-10 | Oxigene Inc | Zusammensetzungen und verfahren mit verbesserter therapeutischer aktivität |
| CN101085743B (zh) * | 2006-06-06 | 2012-02-15 | 浙江大德药业集团有限公司 | 含氟烷氧基康普立停衍生物及制法和用途 |
| US20080114021A1 (en) * | 2006-11-09 | 2008-05-15 | University Of Maryland Baltimore | Use Of 5,6-Dimethylxanthenone-4-Acetic Acid as an Antimicrobial Agent |
| US20080114695A1 (en) * | 2006-11-10 | 2008-05-15 | Semantic Components S.L. | Process for implementing a method for the on-line sale of software product use licenses through a data network, and software component which allows carrying out said process |
| SI2219451T1 (sl) | 2007-11-21 | 2015-02-27 | Oxigene, Inc. | Postopek za zdravljenje hematopoetskih neoplazem |
| US9353150B2 (en) | 2012-12-04 | 2016-05-31 | Massachusetts Institute Of Technology | Substituted pyrazino[1′,2′:1 ,5]pyrrolo[2,3-b]-indole-1,4-diones for cancer treatment |
| US10201623B2 (en) | 2013-03-15 | 2019-02-12 | Memorial Sloan Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
| EP3337495A4 (de) | 2015-08-18 | 2019-04-10 | Mateon Therapeutics, Inc. | Verwendung von vdas zur verbesserung von immunmodulierenden therapien gegen tumoren |
| WO2017197045A1 (en) | 2016-05-11 | 2017-11-16 | Movassaghi Mohammad | Convergent and enantioselective total synthesis of communesin analogs |
| WO2018209239A1 (en) | 2017-05-11 | 2018-11-15 | Massachusetts Institute Of Technology | Potent agelastatin derivatives as modulators for cancer invasion and metastasis |
| US10640508B2 (en) | 2017-10-13 | 2020-05-05 | Massachusetts Institute Of Technology | Diazene directed modular synthesis of compounds with quaternary carbon centers |
| US11535634B2 (en) | 2019-06-05 | 2022-12-27 | Massachusetts Institute Of Technology | Compounds, conjugates, and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines and uses thereof |
| WO2022182415A1 (en) | 2021-02-24 | 2022-09-01 | Massachusetts Institute Of Technology | Himastatin derivatives, and processes of preparation thereof, and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4996237A (en) * | 1987-01-06 | 1991-02-26 | Arizona Board Of Regents | Combretastatin A-4 |
| GB9106177D0 (en) * | 1991-03-22 | 1991-05-08 | Aston Molecules Ltd | Substituted diphenylethylenes and analogues or derivatives thereof |
| US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| US5554638A (en) * | 1993-05-24 | 1996-09-10 | Duke University | Methods for improving therapeutic effectiveness of agents for the treatment of solid tumors and other disorders |
| US5561122A (en) * | 1994-12-22 | 1996-10-01 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Combretastatin A-4 prodrug |
| DE69942645D1 (en) * | 1998-01-09 | 2010-09-16 | Body Corporate Of The State Of | Synthese von combretastatin a-4 prodrugs |
| JP2002537262A (ja) * | 1999-02-18 | 2002-11-05 | オキシジェン，インコーポレイティド | 血管破壊のターゲッティングに使用するための組成物および方法 |
| GB9918912D0 (en) * | 1999-08-12 | 1999-10-13 | Angiogene Pharm Ltd | New stilbenes with vascular damaging activity |
| US6670344B2 (en) * | 2000-09-14 | 2003-12-30 | Bristol-Myers Squibb Company | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di- amino acid salts, and mono- and di-amino acid ester salts |
| US6670334B2 (en) * | 2001-01-05 | 2003-12-30 | University Of Virginia Patent Foundation | Method and compositions for treating the inflammatory response |
-
2000
- 2000-08-15 GB GBGB0019944.8A patent/GB0019944D0/en not_active Ceased
-
2001
- 2001-08-15 EP EP01955467A patent/EP1311514B1/de not_active Expired - Lifetime
- 2001-08-15 WO PCT/GB2001/003668 patent/WO2002014329A1/en active IP Right Grant
- 2001-08-15 PT PT01955467T patent/PT1311514E/pt unknown
- 2001-08-15 AU AU2001277629A patent/AU2001277629A1/en not_active Abandoned
- 2001-08-15 DE DE60108647T patent/DE60108647T2/de not_active Expired - Lifetime
- 2001-08-15 AT AT01955467T patent/ATE287893T1/de not_active IP Right Cessation
-
2003
- 2003-02-14 US US10/367,606 patent/US7105501B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002014329A1 (en) | 2002-02-21 |
| GB0019944D0 (en) | 2000-09-27 |
| US7105501B2 (en) | 2006-09-12 |
| PT1311514E (pt) | 2005-08-31 |
| AU2001277629A1 (en) | 2002-02-25 |
| US20030181424A1 (en) | 2003-09-25 |
| EP1311514A1 (de) | 2003-05-21 |
| DE60108647D1 (de) | 2005-03-03 |
| EP1311514B1 (de) | 2005-01-26 |
| DE60108647T2 (de) | 2005-12-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |