ATE286128T1 - Conotoxine - Google Patents

Conotoxine

Info

Publication number
ATE286128T1
ATE286128T1 AT03075795T AT03075795T ATE286128T1 AT E286128 T1 ATE286128 T1 AT E286128T1 AT 03075795 T AT03075795 T AT 03075795T AT 03075795 T AT03075795 T AT 03075795T AT E286128 T1 ATE286128 T1 AT E286128T1
Authority
AT
Austria
Prior art keywords
conotoxins
plant
assays
peptides
vivo
Prior art date
Application number
AT03075795T
Other languages
English (en)
Inventor
Baldomero M Olivera
Jean E F Rivier
Lourdes J Cruz
Fe Abogadie
Chris E Hopkins
John Dykert
Josep L Torres
Original Assignee
Salk Inst For Biological Studi
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi, Univ Utah Res Found filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of ATE286128T1 publication Critical patent/ATE286128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
AT03075795T 1993-06-29 1994-06-27 Conotoxine ATE286128T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/084,848 US5432155A (en) 1993-06-29 1993-06-29 Conotoxins I

Publications (1)

Publication Number Publication Date
ATE286128T1 true ATE286128T1 (de) 2005-01-15

Family

ID=22187605

Family Applications (2)

Application Number Title Priority Date Filing Date
AT94920316T ATE248222T1 (de) 1993-06-29 1994-06-27 Conotoxine, die an den acetylcholinrezeptor anbinden
AT03075795T ATE286128T1 (de) 1993-06-29 1994-06-27 Conotoxine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT94920316T ATE248222T1 (de) 1993-06-29 1994-06-27 Conotoxine, die an den acetylcholinrezeptor anbinden

Country Status (6)

Country Link
US (3) US5432155A (de)
EP (2) EP0706566B1 (de)
AT (2) ATE248222T1 (de)
CA (1) CA2165566C (de)
DE (2) DE69434217T2 (de)
WO (1) WO1995001436A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) * 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
WO1992006191A1 (en) * 1990-09-28 1992-04-16 Protein Engineering Corporation Proteinaceous anti-dental plaque agents
ES2287206T3 (es) * 1991-03-01 2007-12-16 Dyax Corporation Proceso para el desarrollo de mini-proteinas de union.
US5854217A (en) 1992-09-28 1998-12-29 Bearsden Bio, Inc. Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function
US5514774A (en) * 1993-06-29 1996-05-07 University Of Utah Research Foundation Conotoxin peptides
US5589340A (en) * 1993-06-29 1996-12-31 University Of Utah Research Foundation Process and primers for identifying nucleic acids encoding A-lineage conotoxin peptides
US5739276A (en) * 1994-10-07 1998-04-14 University Of Utah Research Foundation Conotoxin peptides
CA2216751A1 (en) * 1995-04-17 1996-10-24 Doju Yoshikami Conotoxin peptides
US5670622A (en) * 1996-02-15 1997-09-23 University Of Utah Research Foundation Conotoxin peptide PIIIA
US6054429A (en) * 1996-03-08 2000-04-25 Elan Pharmaceuticals, Inc. Epidural method of producing analgesia
US5965534A (en) * 1995-11-22 1999-10-12 Alcon Laboratories, Inc. Use of ω-conotoxin analogs for treating retinal and optic nerve head damage
US5672682A (en) * 1996-03-18 1997-09-30 University Of Utah Research Foundation Conotoxin peptide PVIIA
JP2002513380A (ja) * 1996-07-22 2002-05-08 コグネティックス・インコーポレイテッド コナントキンの使用
US6277825B1 (en) 1996-07-22 2001-08-21 University Of Utah Research Foundation Use of conantokins for treating pain
CA2261568A1 (en) * 1996-07-22 1998-01-29 University Of Utah Research Foundation Conantokins
WO1998037191A1 (de) * 1997-02-20 1998-08-27 Forssmann Wolf Georg Humanes zirkulierendes hnlp (humanes neutrophilen-lymphocyten-peptid)
US5844077A (en) * 1997-04-28 1998-12-01 Cytotherapeutics, Inc. Use of conantokins for producing analgesia or for neuroprotection
US5866682A (en) * 1997-05-15 1999-02-02 University Of Utah Research Foundation Conopeptides AuIA, AuIB and AuIC
US6624288B1 (en) 1997-12-16 2003-09-23 Cognetix, Inc. Gamma-conopeptides
US6265541B1 (en) 1997-12-31 2001-07-24 University Of Utah Research Foundation Uses of α-conotoxin peptides
US5969096A (en) * 1998-06-26 1999-10-19 The Salk Institute For Biological Studies Conotoxin peptides
US6525021B1 (en) 1998-10-20 2003-02-25 Cognetix, Inc. Contulakin-G, analogs thereof and uses therefor
US6369193B1 (en) * 1998-10-20 2002-04-09 University Of Utah Research Foundation Contulakin-G, analogs thereof and uses therefor
FR2785613B1 (fr) * 1998-11-10 2001-01-05 Commissariat Energie Atomique Conotoxine isolee a partir du venin de conus ermineus, ses analogues et ses applications
US6399575B1 (en) * 1998-11-10 2002-06-04 Auburn University Methods and compositions for targeting compounds to the central nervous system
AU778353B2 (en) 1999-01-22 2004-12-02 Cognetix, Inc. Alpha-conotoxin peptides
US20040204362A1 (en) * 1999-01-22 2004-10-14 The University Of Utah Research Foundation Alpha-conotoxin peptides
US6855805B2 (en) 1999-01-22 2005-02-15 University Of Utah Research Foundation α-conotoxin peptides
CA2361534C (en) * 1999-01-29 2011-08-30 University Of Utah Research Foundation Alpha-conotoxin peptides
US6797808B1 (en) * 1999-01-29 2004-09-28 University Of Utah Research Foundation α-conotoxin peptides
WO2000044769A1 (en) * 1999-01-29 2000-08-03 University Of Utah Research Foundation Conotoxin peptides
WO2000046371A1 (en) 1999-02-04 2000-08-10 University Of Utah Research Foundation Tau-conotoxin peptides
JP2003520199A (ja) 1999-08-10 2003-07-02 ユーエイビー リサーチ ファンデーション 非ステロイド性抗炎症薬及び天然産コノトキシンを使用する外傷性脳及び脊髄損傷、並びに他の神経原性症状の治療方法
US6399574B1 (en) 2000-03-22 2002-06-04 University Of Utah Research Foundation Use of conantokins
WO2002002590A2 (en) * 2000-06-30 2002-01-10 University Of Utah Research Foundation I-superfamily conotoxins
GB0021306D0 (en) * 2000-08-30 2000-10-18 Zeneca Mogen B V Control of crop pests and animal parasites through direct neuronal uptake
US20030109670A1 (en) * 2001-02-09 2003-06-12 University Of Utah Research Foundation Cone snail peptides
AUPR409401A0 (en) 2001-03-29 2001-04-26 University Of Melbourne, The Analgesic compound
US20090062211A1 (en) * 2003-03-05 2009-03-05 Florida Atlantic University Conopeptides and methods of use
US20040176303A1 (en) * 2003-03-05 2004-09-09 Frank Mari Conopeptides and methods of use
US20060019892A1 (en) * 2003-03-05 2006-01-26 Florida Atlantic University Conopeptides and methods of use
JP4095494B2 (ja) * 2003-05-30 2008-06-04 キヤノン株式会社 眼科画像処理装置及び処理方法
AU2011348220B2 (en) 2010-12-22 2017-09-07 The Salk Institute For Biological Studies Cyclic CRF antagonist peptides
BR112013023674A2 (pt) 2011-03-16 2016-12-13 Amgen Inc inibidores potentes e seletivos de nav1.3 e nav1.7
AR096927A1 (es) 2013-03-12 2016-02-10 Amgen Inc INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7
WO2014165277A2 (en) 2013-03-12 2014-10-09 Amgen Inc. POTENT AND SELECTIVE INHIBITORS OF Nav1.7
CN105377286B (zh) * 2013-05-31 2021-07-02 犹他大学研究基金会 芋螺毒素(conotoxin)肽，其医药组合物和用途
WO2016101274A1 (zh) * 2014-12-26 2016-06-30 深圳华大基因研究院 芋螺毒素肽κ-CPTx-btl01、其制备方法及应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4447356A (en) * 1981-04-17 1984-05-08 Olivera Baldomero M Conotoxins
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
FR2647677B1 (fr) * 1989-05-31 1991-09-27 Roussel Uclaf Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
US5231011A (en) * 1991-04-18 1993-07-27 University Of Utah Segregated folding determinants for small disulfide-rich peptides
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method

Also Published As

Publication number Publication date
DE69434217D1 (de) 2005-02-03
EP1336617B1 (de) 2004-12-29
ATE248222T1 (de) 2003-09-15
US5432155A (en) 1995-07-11
DE69433090T2 (de) 2004-02-26
EP1336617A2 (de) 2003-08-20
EP1336617A3 (de) 2003-12-10
AU7115894A (en) 1995-01-24
CA2165566C (en) 2003-06-24
DE69433090D1 (de) 2003-10-02
DE69434217T2 (de) 2006-05-11
CA2165566A1 (en) 1995-01-12
WO1995001436A1 (en) 1995-01-12
USRE39240E1 (en) 2006-08-15
US5700778A (en) 1997-12-23
EP0706566B1 (de) 2003-08-27
AU678837B2 (en) 1997-06-12
EP0706566A1 (de) 1996-04-17

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