ATE285231T1 - Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren - Google Patents
Verwendung von aryl-n-substituierten carboxamiden zum töten von tumorenInfo
- Publication number
- ATE285231T1 ATE285231T1 AT97915884T AT97915884T ATE285231T1 AT E285231 T1 ATE285231 T1 AT E285231T1 AT 97915884 T AT97915884 T AT 97915884T AT 97915884 T AT97915884 T AT 97915884T AT E285231 T1 ATE285231 T1 AT E285231T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- substituted carboxamides
- kill tumors
- substituted
- kill
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 150000003857 carboxamides Chemical class 0.000 title 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 abstract 2
- -1 N-substituted benzamides Chemical class 0.000 abstract 2
- 150000005480 nicotinamides Chemical class 0.000 abstract 2
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940054066 benzamide antipsychotics Drugs 0.000 abstract 1
- 150000003936 benzamides Chemical class 0.000 abstract 1
- 235000005152 nicotinamide Nutrition 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1307296P | 1996-03-08 | 1996-03-08 | |
| PCT/US1997/003659 WO1997032576A1 (en) | 1996-03-08 | 1997-03-03 | Use of aryl n-substituted carboxamides to kill tumors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE285231T1 true ATE285231T1 (de) | 2005-01-15 |
Family
ID=21758161
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97915884T ATE285231T1 (de) | 1996-03-08 | 1997-03-03 | Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren |
| AT97908038T ATE300300T1 (de) | 1996-03-08 | 1997-03-03 | Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97908038T ATE300300T1 (de) | 1996-03-08 | 1997-03-03 | Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6028111A (de) |
| EP (2) | EP0927030B1 (de) |
| JP (2) | JP2000507223A (de) |
| AT (2) | ATE285231T1 (de) |
| AU (2) | AU723706B2 (de) |
| CA (2) | CA2248109A1 (de) |
| DE (2) | DE69732036D1 (de) |
| IL (2) | IL126110A0 (de) |
| WO (2) | WO1997032576A1 (de) |
| ZA (2) | ZA971892B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
| US6100299A (en) * | 1996-03-08 | 2000-08-08 | Oxigene, Inc. | N-acetyl 3-chloroprocainamide, acid addition salts thereof, and methods of use |
| PL190755B1 (pl) * | 1999-01-07 | 2006-01-31 | Pharmena Sp Z Oo | Preparat do leczenia i profilaktyki chorób skóry |
| WO2000042040A1 (en) | 1999-01-11 | 2000-07-20 | Agouron Pharmaceuticals, Inc. | Tricyclic inhibitors of poly(adp-ribose) polymerases |
| IT1306141B1 (it) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche. |
| CA2397493A1 (en) | 2000-01-27 | 2001-08-02 | Cytovia, Inc. | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| AU2002309963B2 (en) | 2001-05-21 | 2007-03-01 | Alcon, Inc. | Use of NF-KAPPA-B inhibitors to treat dry eye disorders |
| US20040067985A1 (en) * | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
| US7332479B2 (en) * | 2003-09-10 | 2008-02-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular NAD+ and cADPR as potent anti-inflammatory agents |
| DE102004011720B4 (de) * | 2004-03-10 | 2008-04-03 | Bayer Schering Pharma Aktiengesellschaft | Radiohalogenierte Benzamidderivate und deren Verwendung in der Tumordiagnostik und Tumortherapie |
| WO2005090302A2 (en) * | 2004-03-16 | 2005-09-29 | Boehringer Ingelheim International Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
| CA2609615A1 (en) * | 2005-03-16 | 2006-09-28 | Genetic Health Enterprises (Pty), Ltd. | Medicinal compositions of salts, chelates and/or free acids of alpha hydroxyl organic acids and related processes and methods |
| EP1877054A2 (de) * | 2005-03-30 | 2008-01-16 | Sirtris Pharmaceuticals, Inc. | Nicotinamidribosid und analoge davon |
| US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
| US20060292099A1 (en) * | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
| US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
| EP3836912B1 (de) | 2018-08-15 | 2024-05-01 | Pharmacyl AB | Kombinationen von substitutierten benzamiden und 5-asa-wirkstoffen |
| US12280132B2 (en) * | 2021-11-29 | 2025-04-22 | The Procter & Gamble Company | Skin care composition |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3055891A (en) * | 1960-03-21 | 1962-09-25 | Searle & Co | N-(aminoalkylcarbamoylpiperidinoalkyl)phenothiazines |
| CH481132A (de) * | 1966-06-09 | 1969-11-15 | Ciba Geigy | Verfahren zur Herstellung von neuen Isoxazolen |
| FR8287M (de) * | 1968-12-31 | 1970-11-09 | ||
| DE2623228C3 (de) * | 1976-05-24 | 1981-09-10 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | N-Acyl-substituierte Benzamide, Verfahren zu ihrer Herstellung und Arzneimittel, enthaltend solche Benzamide |
| GB1573186A (en) * | 1977-09-14 | 1980-08-20 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
| US4263322A (en) * | 1979-03-01 | 1981-04-21 | Riet Bartholomeus Van T | Hydroxy benzohydroxamic acids and benzamides |
| US4394389A (en) * | 1979-03-01 | 1983-07-19 | Riet Bartholomeus Van T | Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors |
| US4448730A (en) * | 1981-03-24 | 1984-05-15 | Riet Bartholomeus Van T | Hydroxybenzohydroxamic acids, benzamides and esters and related compounds as ribonucleotide reductase inhibitors |
| WO1984004246A1 (en) * | 1983-04-21 | 1984-11-08 | Howard L Elford | Oncolytic drug combinations |
| US4623659A (en) * | 1983-05-23 | 1986-11-18 | Riet Bartholomeus Van T | Polyhydroxybenzoic acid derivatives |
| US4942253A (en) * | 1983-05-23 | 1990-07-17 | Riet Bartholomeus Van T | Polyhydroxybenzoic acid derivatives |
| US5183828A (en) * | 1983-05-23 | 1993-02-02 | Riet Bartholomeus Van T | Polyhydroxybenzoic acid derivatives |
| US5215738A (en) * | 1985-05-03 | 1993-06-01 | Sri International | Benzamide and nicotinamide radiosensitizers |
| ZA885929B (en) * | 1987-08-25 | 1989-04-26 | Oxi Gene Inc | Agents for use in tumor or cancer cell killing therapy |
| US5281623A (en) * | 1990-08-27 | 1994-01-25 | Eli Lilly And Company | Method for treating inflammation |
| EP0610444B1 (de) * | 1991-10-31 | 2003-01-29 | ELFORD, Howard L. | Verwendung eines polyhydroxybenzamids oder dessen Derivat zur Herstellung eines Medikaments für die Behandlung von viralen Infektionen |
| US5350770A (en) * | 1992-07-28 | 1994-09-27 | Elford Howard L | Therapeutic process for the treatment of septic shock |
| US5366996A (en) * | 1992-12-07 | 1994-11-22 | Elford Howard L | Method of treating hemoglobinopathies |
| FR2712809B1 (fr) * | 1993-11-26 | 1996-04-12 | Union Pharma Scient Appl | Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide. |
| US5563143A (en) * | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
| EP1304322A3 (de) * | 1995-08-22 | 2003-11-19 | Japan Tobacco Inc. | Karbonsäureverbindung und ihre Verwendung |
| TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
-
1997
- 1997-02-27 US US08/807,071 patent/US6028111A/en not_active Expired - Fee Related
- 1997-03-03 IL IL12611097A patent/IL126110A0/xx unknown
- 1997-03-03 CA CA002248109A patent/CA2248109A1/en not_active Abandoned
- 1997-03-03 JP JP9531937A patent/JP2000507223A/ja not_active Ceased
- 1997-03-03 AU AU19884/97A patent/AU723706B2/en not_active Ceased
- 1997-03-03 WO PCT/US1997/003659 patent/WO1997032576A1/en not_active Ceased
- 1997-03-03 IL IL12610997A patent/IL126109A0/xx unknown
- 1997-03-03 DE DE69732036T patent/DE69732036D1/de not_active Expired - Lifetime
- 1997-03-03 AU AU23196/97A patent/AU724909B2/en not_active Ceased
- 1997-03-03 EP EP97915884A patent/EP0927030B1/de not_active Expired - Lifetime
- 1997-03-03 AT AT97915884T patent/ATE285231T1/de not_active IP Right Cessation
- 1997-03-03 WO PCT/US1997/003515 patent/WO1997032582A1/en not_active Ceased
- 1997-03-03 EP EP97908038A patent/EP1009402B1/de not_active Expired - Lifetime
- 1997-03-03 AT AT97908038T patent/ATE300300T1/de not_active IP Right Cessation
- 1997-03-03 JP JP9531993A patent/JP2000506169A/ja not_active Ceased
- 1997-03-03 DE DE69733843T patent/DE69733843T2/de not_active Expired - Fee Related
- 1997-03-03 CA CA002248125A patent/CA2248125A1/en not_active Abandoned
- 1997-03-05 ZA ZA971892A patent/ZA971892B/xx unknown
- 1997-03-05 ZA ZA971891A patent/ZA971891B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1009402A1 (de) | 2000-06-21 |
| AU723706B2 (en) | 2000-09-07 |
| EP0927030B1 (de) | 2004-12-22 |
| CA2248109A1 (en) | 1997-09-12 |
| ATE300300T1 (de) | 2005-08-15 |
| ZA971892B (en) | 1998-09-07 |
| EP1009402B1 (de) | 2005-07-27 |
| DE69733843T2 (de) | 2006-06-01 |
| AU724909B2 (en) | 2000-10-05 |
| EP0927030A4 (de) | 2000-01-26 |
| DE69732036D1 (de) | 2005-01-27 |
| AU2319697A (en) | 1997-09-22 |
| JP2000506169A (ja) | 2000-05-23 |
| ZA971891B (en) | 1998-09-07 |
| DE69733843D1 (de) | 2005-09-01 |
| JP2000507223A (ja) | 2000-06-13 |
| WO1997032582A1 (en) | 1997-09-12 |
| EP0927030A1 (de) | 1999-07-07 |
| EP1009402A4 (de) | 2000-06-21 |
| CA2248125A1 (en) | 1997-09-12 |
| IL126110A0 (en) | 1999-05-09 |
| AU1988497A (en) | 1997-09-22 |
| WO1997032576A1 (en) | 1997-09-12 |
| IL126109A0 (en) | 1999-05-09 |
| US6028111A (en) | 2000-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |