ATE285231T1 - Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren - Google Patents

Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren

Info

Publication number
ATE285231T1
ATE285231T1 AT97915884T AT97915884T ATE285231T1 AT E285231 T1 ATE285231 T1 AT E285231T1 AT 97915884 T AT97915884 T AT 97915884T AT 97915884 T AT97915884 T AT 97915884T AT E285231 T1 ATE285231 T1 AT E285231T1
Authority
AT
Austria
Prior art keywords
aryl
substituted carboxamides
kill tumors
substituted
kill
Prior art date
Application number
AT97915884T
Other languages
English (en)
Inventor
Ronald W Pero
Anders Olsson
Tomas Ekberg
Alan Schwartz
David Chaplin
Original Assignee
Oxigene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxigene Inc filed Critical Oxigene Inc
Application granted granted Critical
Publication of ATE285231T1 publication Critical patent/ATE285231T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97915884T 1996-03-08 1997-03-03 Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren ATE285231T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1307296P 1996-03-08 1996-03-08
PCT/US1997/003659 WO1997032576A1 (en) 1996-03-08 1997-03-03 Use of aryl n-substituted carboxamides to kill tumors

Publications (1)

Publication Number Publication Date
ATE285231T1 true ATE285231T1 (de) 2005-01-15

Family

ID=21758161

Family Applications (2)

Application Number Title Priority Date Filing Date
AT97915884T ATE285231T1 (de) 1996-03-08 1997-03-03 Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren
AT97908038T ATE300300T1 (de) 1996-03-08 1997-03-03 Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT97908038T ATE300300T1 (de) 1996-03-08 1997-03-03 Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel

Country Status (10)

Country Link
US (1) US6028111A (de)
EP (2) EP1009402B1 (de)
JP (2) JP2000507223A (de)
AT (2) ATE285231T1 (de)
AU (2) AU724909B2 (de)
CA (2) CA2248125A1 (de)
DE (2) DE69732036D1 (de)
IL (2) IL126110A0 (de)
WO (2) WO1997032582A1 (de)
ZA (2) ZA971891B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases
US6100299A (en) * 1996-03-08 2000-08-08 Oxigene, Inc. N-acetyl 3-chloroprocainamide, acid addition salts thereof, and methods of use
CZ302941B6 (cs) 1999-01-11 2012-01-25 Agouron Pharmaceuticals, Inc. Tricyklická sloucenina a farmaceutický prostredek s jejím obsahem
IT1306141B1 (it) * 1999-05-17 2001-05-30 Giampiero Valletta Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche.
EP1257536A1 (de) * 2000-01-27 2002-11-20 Cytovia, Inc. Substituierte nicotinamiden und analoge als caspaseaktivatoren und apoptose-induzierende mittel und ihre verwendung
CN1509462A (zh) 2001-05-21 2004-06-30 NF-κB抑制剂在治疗干眼疾病中的用途
US20040067985A1 (en) * 2002-10-04 2004-04-08 Fortuna Haviv Method of inhibiting angiogenesis
US7332479B2 (en) * 2003-09-10 2008-02-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Extracellular NAD+ and cADPR as potent anti-inflammatory agents
DE102004011720B4 (de) * 2004-03-10 2008-04-03 Bayer Schering Pharma Aktiengesellschaft Radiohalogenierte Benzamidderivate und deren Verwendung in der Tumordiagnostik und Tumortherapie
WO2005090302A2 (en) * 2004-03-16 2005-09-29 Boehringer Ingelheim International Gmbh Palladium catalyzed indolization of 2-bromo or chloroanilines
JP2008533163A (ja) * 2005-03-16 2008-08-21 ロナルド・ドゥッベルヴェー・ペロ αヒドロキシル有機酸の塩、キレートおよび／または遊離酸の医薬組成物、および関連したプロセスおよび方法
US20070014833A1 (en) * 2005-03-30 2007-01-18 Sirtris Pharmaceuticals, Inc. Treatment of eye disorders with sirtuin modulators
WO2006105440A2 (en) * 2005-03-30 2006-10-05 Sirtris Pharmaceuticals, Inc. Nicotinamide riboside and analogues thereof
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
US20070149466A1 (en) * 2005-07-07 2007-06-28 Michael Milburn Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders
CN112770736A (zh) 2018-08-15 2021-05-07 法玛西尔有限公司 病理性炎症的新医学治疗

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3055891A (en) * 1960-03-21 1962-09-25 Searle & Co N-(aminoalkylcarbamoylpiperidinoalkyl)phenothiazines
CH481132A (de) * 1966-06-09 1969-11-15 Ciba Geigy Verfahren zur Herstellung von neuen Isoxazolen
FR8287M (de) * 1968-12-31 1970-11-09
DE2623228C3 (de) * 1976-05-24 1981-09-10 Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren N-Acyl-substituierte Benzamide, Verfahren zu ihrer Herstellung und Arzneimittel, enthaltend solche Benzamide
GB1573186A (en) * 1977-09-14 1980-08-20 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
US4263322A (en) * 1979-03-01 1981-04-21 Riet Bartholomeus Van T Hydroxy benzohydroxamic acids and benzamides
US4394389A (en) * 1979-03-01 1983-07-19 Riet Bartholomeus Van T Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors
US4448730A (en) * 1981-03-24 1984-05-15 Riet Bartholomeus Van T Hydroxybenzohydroxamic acids, benzamides and esters and related compounds as ribonucleotide reductase inhibitors
EP0140958B1 (de) * 1983-04-21 1989-12-20 ELFORD, Howard L. Onkolytische arzneimittelkombinationen
US4942253A (en) * 1983-05-23 1990-07-17 Riet Bartholomeus Van T Polyhydroxybenzoic acid derivatives
US4623659A (en) * 1983-05-23 1986-11-18 Riet Bartholomeus Van T Polyhydroxybenzoic acid derivatives
US5183828A (en) * 1983-05-23 1993-02-02 Riet Bartholomeus Van T Polyhydroxybenzoic acid derivatives
US5215738A (en) * 1985-05-03 1993-06-01 Sri International Benzamide and nicotinamide radiosensitizers
ZA885929B (en) * 1987-08-25 1989-04-26 Oxi Gene Inc Agents for use in tumor or cancer cell killing therapy
US5281623A (en) * 1990-08-27 1994-01-25 Eli Lilly And Company Method for treating inflammation
EP0610444B1 (de) * 1991-10-31 2003-01-29 ELFORD, Howard L. Verwendung eines polyhydroxybenzamids oder dessen Derivat zur Herstellung eines Medikaments für die Behandlung von viralen Infektionen
US5350770A (en) * 1992-07-28 1994-09-27 Elford Howard L Therapeutic process for the treatment of septic shock
US5366996A (en) * 1992-12-07 1994-11-22 Elford Howard L Method of treating hemoglobinopathies
FR2712809B1 (fr) * 1993-11-26 1996-04-12 Union Pharma Scient Appl Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide.
US5563143A (en) * 1994-09-21 1996-10-08 Pfizer Inc. Catechol diether compounds as inhibitors of TNF release
EP1304322A3 (de) * 1995-08-22 2003-11-19 Japan Tobacco Inc. Karbonsäureverbindung und ihre Verwendung
TW429148B (en) * 1995-10-27 2001-04-11 Pfizer Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases

Also Published As

Publication number Publication date
AU1988497A (en) 1997-09-22
EP0927030A4 (de) 2000-01-26
IL126109A0 (en) 1999-05-09
EP1009402A1 (de) 2000-06-21
ATE300300T1 (de) 2005-08-15
CA2248109A1 (en) 1997-09-12
EP1009402B1 (de) 2005-07-27
JP2000507223A (ja) 2000-06-13
WO1997032582A1 (en) 1997-09-12
WO1997032576A1 (en) 1997-09-12
AU724909B2 (en) 2000-10-05
AU2319697A (en) 1997-09-22
ZA971891B (en) 1998-09-07
EP0927030B1 (de) 2004-12-22
IL126110A0 (en) 1999-05-09
AU723706B2 (en) 2000-09-07
EP0927030A1 (de) 1999-07-07
EP1009402A4 (de) 2000-06-21
DE69733843D1 (de) 2005-09-01
CA2248125A1 (en) 1997-09-12
US6028111A (en) 2000-02-22
DE69732036D1 (de) 2005-01-27
ZA971892B (en) 1998-09-07
DE69733843T2 (de) 2006-06-01
JP2000506169A (ja) 2000-05-23

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