ATE300300T1 - Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel - Google Patents
Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittelInfo
- Publication number
- ATE300300T1 ATE300300T1 AT97908038T AT97908038T ATE300300T1 AT E300300 T1 ATE300300 T1 AT E300300T1 AT 97908038 T AT97908038 T AT 97908038T AT 97908038 T AT97908038 T AT 97908038T AT E300300 T1 ATE300300 T1 AT E300300T1
- Authority
- AT
- Austria
- Prior art keywords
- benzamides
- inflammatory agents
- compositions
- nicotinamides
- benzamide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1307296P | 1996-03-08 | 1996-03-08 | |
PCT/US1997/003515 WO1997032582A1 (en) | 1996-03-08 | 1997-03-03 | Compositions and use of benzamides and nicotinamides as anti-inflammatory agents |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE300300T1 true ATE300300T1 (de) | 2005-08-15 |
Family
ID=21758161
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97915884T ATE285231T1 (de) | 1996-03-08 | 1997-03-03 | Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren |
AT97908038T ATE300300T1 (de) | 1996-03-08 | 1997-03-03 | Zusammensetzungen und verwendungvon benzamiden als entzuendungshemmende mittel |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97915884T ATE285231T1 (de) | 1996-03-08 | 1997-03-03 | Verwendung von aryl-n-substituierten carboxamiden zum töten von tumoren |
Country Status (10)
Country | Link |
---|---|
US (1) | US6028111A (de) |
EP (2) | EP0927030B1 (de) |
JP (2) | JP2000507223A (de) |
AT (2) | ATE285231T1 (de) |
AU (2) | AU723706B2 (de) |
CA (2) | CA2248109A1 (de) |
DE (2) | DE69732036D1 (de) |
IL (2) | IL126110A0 (de) |
WO (2) | WO1997032576A1 (de) |
ZA (2) | ZA971892B (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
US6100299A (en) * | 1996-03-08 | 2000-08-08 | Oxigene, Inc. | N-acetyl 3-chloroprocainamide, acid addition salts thereof, and methods of use |
SI20691B (sl) | 1999-01-11 | 2008-10-31 | Agouron Pharma | Triciklični inhibitorji poli(ADP-riboza) polimeraz |
IT1306141B1 (it) * | 1999-05-17 | 2001-05-30 | Giampiero Valletta | Composizione per il trattamento del prurito uremico e di forme diprurito non riconducibili a lesioni organiche. |
AU2001231143A1 (en) * | 2000-01-27 | 2001-08-07 | Cytovia, Inc. | Substituted nicotinamides and analogs as activators of caspases and inducers of apoptosis and the use thereof |
CN1509462A (zh) | 2001-05-21 | 2004-06-30 | NF-κB抑制剂在治疗干眼疾病中的用途 | |
US20040067985A1 (en) * | 2002-10-04 | 2004-04-08 | Fortuna Haviv | Method of inhibiting angiogenesis |
US7332479B2 (en) * | 2003-09-10 | 2008-02-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Extracellular NAD+ and cADPR as potent anti-inflammatory agents |
DE102004011720B4 (de) * | 2004-03-10 | 2008-04-03 | Bayer Schering Pharma Aktiengesellschaft | Radiohalogenierte Benzamidderivate und deren Verwendung in der Tumordiagnostik und Tumortherapie |
US7126009B2 (en) * | 2004-03-16 | 2006-10-24 | Boehringer Ingelheim International, Gmbh | Palladium catalyzed indolization of 2-bromo or chloroanilines |
EP1858500A4 (de) * | 2005-03-16 | 2013-01-16 | Genetic Health Entpr Pty Ltd | Medizinische zusammensetzungen von salzen, chelaten und/oder freien säuren organischer alpha-hydroxyl-säuren und damit zusammenhängende vorgänge und verfahren |
US20070014833A1 (en) * | 2005-03-30 | 2007-01-18 | Sirtris Pharmaceuticals, Inc. | Treatment of eye disorders with sirtuin modulators |
US20060229265A1 (en) * | 2005-03-30 | 2006-10-12 | Sirtris Pharmaceuticals, Inc. | Nicotinamide riboside and analogues thereof |
US20060292099A1 (en) * | 2005-05-25 | 2006-12-28 | Michael Milburn | Treatment of eye disorders with sirtuin modulators |
US20070149466A1 (en) * | 2005-07-07 | 2007-06-28 | Michael Milburn | Methods and related compositions for treating or preventing obesity, insulin resistance disorders, and mitochondrial-associated disorders |
AU2019322564A1 (en) | 2018-08-15 | 2021-03-25 | Pharmacyl Ab | A new medical treatment for pathologic inflammation |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3055891A (en) * | 1960-03-21 | 1962-09-25 | Searle & Co | N-(aminoalkylcarbamoylpiperidinoalkyl)phenothiazines |
CH481132A (de) * | 1966-06-09 | 1969-11-15 | Ciba Geigy | Verfahren zur Herstellung von neuen Isoxazolen |
FR8287M (de) * | 1968-12-31 | 1970-11-09 | ||
DE2623228C3 (de) * | 1976-05-24 | 1981-09-10 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | N-Acyl-substituierte Benzamide, Verfahren zu ihrer Herstellung und Arzneimittel, enthaltend solche Benzamide |
GB1573186A (en) * | 1977-09-14 | 1980-08-20 | Wyeth John & Brother Ltd | 4-aminoquinoline derivatives |
US4394389A (en) * | 1979-03-01 | 1983-07-19 | Riet Bartholomeus Van T | Hydroxybenzohydroxamic acids, benzamides and esters as ribonucleotide reductase inhibitors |
US4263322A (en) * | 1979-03-01 | 1981-04-21 | Riet Bartholomeus Van T | Hydroxy benzohydroxamic acids and benzamides |
US4448730A (en) * | 1981-03-24 | 1984-05-15 | Riet Bartholomeus Van T | Hydroxybenzohydroxamic acids, benzamides and esters and related compounds as ribonucleotide reductase inhibitors |
DE3480762D1 (de) * | 1983-04-21 | 1990-01-25 | Howard L Elford | Onkolytische arzneimittelkombinationen. |
US4942253A (en) * | 1983-05-23 | 1990-07-17 | Riet Bartholomeus Van T | Polyhydroxybenzoic acid derivatives |
US4623659A (en) * | 1983-05-23 | 1986-11-18 | Riet Bartholomeus Van T | Polyhydroxybenzoic acid derivatives |
US5183828A (en) * | 1983-05-23 | 1993-02-02 | Riet Bartholomeus Van T | Polyhydroxybenzoic acid derivatives |
US5215738A (en) * | 1985-05-03 | 1993-06-01 | Sri International | Benzamide and nicotinamide radiosensitizers |
ZA885929B (en) * | 1987-08-25 | 1989-04-26 | Oxi Gene Inc | Agents for use in tumor or cancer cell killing therapy |
US5281623A (en) * | 1990-08-27 | 1994-01-25 | Eli Lilly And Company | Method for treating inflammation |
EP0610444B1 (de) * | 1991-10-31 | 2003-01-29 | ELFORD, Howard L. | Verwendung eines polyhydroxybenzamids oder dessen Derivat zur Herstellung eines Medikaments für die Behandlung von viralen Infektionen |
US5350770A (en) * | 1992-07-28 | 1994-09-27 | Elford Howard L | Therapeutic process for the treatment of septic shock |
US5366996A (en) * | 1992-12-07 | 1994-11-22 | Elford Howard L | Method of treating hemoglobinopathies |
FR2712809B1 (fr) * | 1993-11-26 | 1996-04-12 | Union Pharma Scient Appl | Nouvelle composition pharmaceutique destinée à la préparation d'une poudre stable contenant, à titre d'ingrédient actif, une association d'acide acétylsalicylique et de métoclopramide. |
US5563143A (en) * | 1994-09-21 | 1996-10-08 | Pfizer Inc. | Catechol diether compounds as inhibitors of TNF release |
USRE39088E1 (en) * | 1995-08-22 | 2006-05-02 | Japan Tobacco, Inc. | Amide compounds and use of the same |
TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
-
1997
- 1997-02-27 US US08/807,071 patent/US6028111A/en not_active Expired - Fee Related
- 1997-03-03 AT AT97915884T patent/ATE285231T1/de not_active IP Right Cessation
- 1997-03-03 CA CA002248109A patent/CA2248109A1/en not_active Abandoned
- 1997-03-03 WO PCT/US1997/003659 patent/WO1997032576A1/en active IP Right Grant
- 1997-03-03 DE DE69732036T patent/DE69732036D1/de not_active Expired - Lifetime
- 1997-03-03 IL IL12611097A patent/IL126110A0/xx unknown
- 1997-03-03 IL IL12610997A patent/IL126109A0/xx unknown
- 1997-03-03 CA CA002248125A patent/CA2248125A1/en not_active Abandoned
- 1997-03-03 AU AU19884/97A patent/AU723706B2/en not_active Ceased
- 1997-03-03 EP EP97915884A patent/EP0927030B1/de not_active Expired - Lifetime
- 1997-03-03 WO PCT/US1997/003515 patent/WO1997032582A1/en active IP Right Grant
- 1997-03-03 AT AT97908038T patent/ATE300300T1/de not_active IP Right Cessation
- 1997-03-03 DE DE69733843T patent/DE69733843T2/de not_active Expired - Fee Related
- 1997-03-03 JP JP9531937A patent/JP2000507223A/ja not_active Ceased
- 1997-03-03 AU AU23196/97A patent/AU724909B2/en not_active Ceased
- 1997-03-03 JP JP9531993A patent/JP2000506169A/ja not_active Ceased
- 1997-03-03 EP EP97908038A patent/EP1009402B1/de not_active Expired - Lifetime
- 1997-03-05 ZA ZA971892A patent/ZA971892B/xx unknown
- 1997-03-05 ZA ZA971891A patent/ZA971891B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2248109A1 (en) | 1997-09-12 |
AU723706B2 (en) | 2000-09-07 |
EP1009402A4 (de) | 2000-06-21 |
WO1997032582A1 (en) | 1997-09-12 |
EP1009402B1 (de) | 2005-07-27 |
IL126110A0 (en) | 1999-05-09 |
JP2000507223A (ja) | 2000-06-13 |
ZA971891B (en) | 1998-09-07 |
EP1009402A1 (de) | 2000-06-21 |
US6028111A (en) | 2000-02-22 |
AU1988497A (en) | 1997-09-22 |
ZA971892B (en) | 1998-09-07 |
AU2319697A (en) | 1997-09-22 |
WO1997032576A1 (en) | 1997-09-12 |
AU724909B2 (en) | 2000-10-05 |
EP0927030A4 (de) | 2000-01-26 |
DE69733843D1 (de) | 2005-09-01 |
JP2000506169A (ja) | 2000-05-23 |
DE69732036D1 (de) | 2005-01-27 |
EP0927030A1 (de) | 1999-07-07 |
IL126109A0 (en) | 1999-05-09 |
CA2248125A1 (en) | 1997-09-12 |
ATE285231T1 (de) | 2005-01-15 |
DE69733843T2 (de) | 2006-06-01 |
EP0927030B1 (de) | 2004-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |