ATE282088T1 - Aminopeptidase, welche von bacillus licheniformis abstammt und verfahren zur herstellung von proteinen des natürlichen typs - Google Patents

Aminopeptidase, welche von bacillus licheniformis abstammt und verfahren zur herstellung von proteinen des natürlichen typs

Info

Publication number
ATE282088T1
ATE282088T1 AT98905849T AT98905849T ATE282088T1 AT E282088 T1 ATE282088 T1 AT E282088T1 AT 98905849 T AT98905849 T AT 98905849T AT 98905849 T AT98905849 T AT 98905849T AT E282088 T1 ATE282088 T1 AT E282088T1
Authority
AT
Austria
Prior art keywords
natural type
proteins
bacillus licheniformis
present
type proteins
Prior art date
Application number
AT98905849T
Other languages
English (en)
Inventor
Young-Phil Lee
Kyuboem Han
Se-Hoon Kim
Soon-Jae Park
Seung-Joo Lee
Original Assignee
Lg Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Chemical Ltd filed Critical Lg Chemical Ltd
Application granted granted Critical
Publication of ATE282088T1 publication Critical patent/ATE282088T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
AT98905849T 1997-02-28 1998-02-16 Aminopeptidase, welche von bacillus licheniformis abstammt und verfahren zur herstellung von proteinen des natürlichen typs ATE282088T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR19970006756 1997-02-28
PCT/KR1998/000032 WO1998038290A1 (en) 1997-02-28 1998-02-16 Aminopeptidase derived from bacillus licheniformis and process for preparation of natural type proteins

Publications (1)

Publication Number Publication Date
ATE282088T1 true ATE282088T1 (de) 2004-11-15

Family

ID=19498475

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98905849T ATE282088T1 (de) 1997-02-28 1998-02-16 Aminopeptidase, welche von bacillus licheniformis abstammt und verfahren zur herstellung von proteinen des natürlichen typs

Country Status (14)

Country Link
US (1) US6428997B1 (de)
EP (1) EP0975742B1 (de)
JP (1) JP3518868B2 (de)
KR (1) KR100369839B1 (de)
AT (1) ATE282088T1 (de)
AU (1) AU6122498A (de)
BR (1) BR9807616A (de)
CA (1) CA2282734C (de)
DE (1) DE69827486T2 (de)
DK (1) DK0975742T3 (de)
ES (1) ES2231962T3 (de)
PL (1) PL191247B1 (de)
PT (1) PT975742E (de)
WO (1) WO1998038290A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2451528C (en) * 2001-07-06 2011-08-16 Lg Life Sciences Ltd. Novel aminopeptidase derived from bacillus licheniformis, gene encoding the aminopeptidase, expression vector containing the gene, transformant and method for preparation thereof
KR100477062B1 (ko) * 2001-07-06 2005-03-17 주식회사 엘지생명과학 바실러스 리케니포미스 유래의 신규한 아미노펩티다아제, 이를 코딩하는 유전자, 이 유전자를 포함하는 발현벡터, 이 발현벡터로 형질전환된 형질전환체 및 이를 이용하는 천연형 단백질의 제조방법
PL206286B1 (pl) * 2001-09-13 2010-07-30 Genentech Incgenentech Inc Komórka Gram-ujemnej bakterii, sposób wytwarzania heterologicznego peptydu, sposób zapobiegania odcinaniu N-końcowego aminokwasu, sposób odcinania N-końcowego aminokwasu i sposób wytwarzania skróconego polipeptydu
MX2009005764A (es) * 2006-11-30 2009-08-24 Biocon Ltd Metodo para producir polipeptidos libres de metionina n-terminal en celulas huesped microbianas.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE122004000009I1 (de) * 1984-08-16 2004-11-18 Savient Pharmaceuticals Inc Methode zur Herstellung von menschlichen Wachstumshormonen.
US5763215A (en) * 1984-08-16 1998-06-09 Bio-Technology General Corporation Method of removing N-terminal amino acid residues from eucaryotic polypeptide analogs and polypeptides produced thereby
US4870017A (en) * 1985-09-20 1989-09-26 Cetus Corporation Bacterial methionine N-terminal peptidase
US5013662A (en) * 1985-09-20 1991-05-07 Cetus Corporation Bacterial methionine n-terminal peptidase
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
AU4213489A (en) * 1988-09-13 1990-04-02 General Hospital Corporation, The Isolation, purification, and characterization of the aminopeptidases: ap1 and ap122
JP2845558B2 (ja) * 1990-03-30 1999-01-13 ダイセル化学工業株式会社 メチオニンアミノペプチダーゼのｄｎａ配列
US5753465A (en) * 1994-08-30 1998-05-19 Carnegie Mellon University Unmodified recombinant human adult hemoglobin production
US6071718A (en) * 1996-11-27 2000-06-06 Abbott Laboratories Methods of producing a recombinant protein

Also Published As

Publication number Publication date
EP0975742A1 (de) 2000-02-02
EP0975742B1 (de) 2004-11-10
JP2000516479A (ja) 2000-12-12
PL335459A1 (en) 2000-04-25
PT975742E (pt) 2005-03-31
WO1998038290A1 (en) 1998-09-03
DE69827486D1 (de) 2004-12-16
BR9807616A (pt) 2000-02-22
ES2231962T3 (es) 2005-05-16
DE69827486T2 (de) 2005-10-13
KR100369839B1 (ko) 2003-06-12
PL191247B1 (pl) 2006-04-28
CA2282734C (en) 2004-10-19
KR19980071239A (ko) 1998-10-26
CA2282734A1 (en) 1998-09-03
US6428997B1 (en) 2002-08-06
JP3518868B2 (ja) 2004-04-12
AU6122498A (en) 1998-09-18
DK0975742T3 (da) 2005-02-14

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