ATE281530T1 - Verfahren zur darstellung von clavulansäure - Google Patents

Verfahren zur darstellung von clavulansäure

Info

Publication number
ATE281530T1
ATE281530T1 AT01976230T AT01976230T ATE281530T1 AT E281530 T1 ATE281530 T1 AT E281530T1 AT 01976230 T AT01976230 T AT 01976230T AT 01976230 T AT01976230 T AT 01976230T AT E281530 T1 ATE281530 T1 AT E281530T1
Authority
AT
Austria
Prior art keywords
clavulanic acid
selective adsorption
preparing clavulanic
preparing
novel
Prior art date
Application number
AT01976230T
Other languages
English (en)
Inventor
Klaus Mosbach
Lei Ye
Yihua Yu
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Application granted granted Critical
Publication of ATE281530T1 publication Critical patent/ATE281530T1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT01976230T 2000-09-18 2001-09-17 Verfahren zur darstellung von clavulansäure ATE281530T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0022841.1A GB0022841D0 (en) 2000-09-18 2000-09-18 Process
PCT/EP2001/010742 WO2002022846A1 (en) 2000-09-18 2001-09-17 Process

Publications (1)

Publication Number Publication Date
ATE281530T1 true ATE281530T1 (de) 2004-11-15

Family

ID=9899649

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01976230T ATE281530T1 (de) 2000-09-18 2001-09-17 Verfahren zur darstellung von clavulansäure

Country Status (9)

Country Link
US (1) US7087748B2 (de)
EP (1) EP1319086B1 (de)
JP (1) JP4944350B2 (de)
AT (1) ATE281530T1 (de)
AU (1) AU2001295569A1 (de)
DE (1) DE60106961T2 (de)
ES (1) ES2231558T3 (de)
GB (1) GB0022841D0 (de)
WO (1) WO2002022846A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4541715B2 (ja) * 2004-01-23 2010-09-08 北越紀州製紙株式会社 分子吸着機能を有するシート
US7985818B2 (en) * 2006-04-10 2011-07-26 R.J. Reynolds Tobacco Company Method to selectively remove safrole from nutmeg oil
CN102369223A (zh) * 2009-01-29 2012-03-07 国家科学和工业研究组织 分子印记聚合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ213963A (en) * 1984-10-27 1989-01-06 Antibioticos Sa Production of clavulanic acid
ES8601999A1 (es) * 1984-10-27 1985-12-01 Antibioticos Sa Procedimiento para mejorar la extraccion del acido clavulanico
SE9102622L (sv) 1991-09-06 1993-03-07 Klaus Mosbach Saett att aastadkomma specifikt adsorptionsmaterial laempligt foer biologiska makromolekyler genom prearrangemang av immobiliserbara till makromolekylen i fraaga bindande funktionella grupper
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DK0867515T3 (da) * 1997-03-24 2000-06-13 Cipan Comp Ind Prod Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre

Also Published As

Publication number Publication date
DE60106961D1 (de) 2004-12-09
EP1319086B1 (de) 2004-11-03
GB0022841D0 (en) 2000-11-01
EP1319086A1 (de) 2003-06-18
ES2231558T3 (es) 2005-05-16
JP2004509136A (ja) 2004-03-25
US7087748B2 (en) 2006-08-08
US20040063930A1 (en) 2004-04-01
AU2001295569A1 (en) 2002-03-26
DE60106961T2 (de) 2005-11-24
JP4944350B2 (ja) 2012-05-30
WO2002022846A1 (en) 2002-03-21

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Legal Events

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