DE60106961D1 - Verfahren zur darstellung von clavulansäure - Google Patents

Verfahren zur darstellung von clavulansäure

Info

Publication number
DE60106961D1
DE60106961D1 DE60106961T DE60106961T DE60106961D1 DE 60106961 D1 DE60106961 D1 DE 60106961D1 DE 60106961 T DE60106961 T DE 60106961T DE 60106961 T DE60106961 T DE 60106961T DE 60106961 D1 DE60106961 D1 DE 60106961D1
Authority
DE
Germany
Prior art keywords
acid
clavulic
presenting
selective adsorption
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60106961T
Other languages
English (en)
Other versions
DE60106961T2 (de
Inventor
Klaus Mosbach
Lei Ye
Yihua Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE60106961D1 publication Critical patent/DE60106961D1/de
Publication of DE60106961T2 publication Critical patent/DE60106961T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/268—Polymers created by use of a template, e.g. molecularly imprinted polymers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE60106961T 2000-09-18 2001-09-17 Verfahren zur Herstellung von Clavulansäure Expired - Lifetime DE60106961T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0022841.1A GB0022841D0 (en) 2000-09-18 2000-09-18 Process
GB0022841 2000-09-18
PCT/EP2001/010742 WO2002022846A1 (en) 2000-09-18 2001-09-17 Process

Publications (2)

Publication Number Publication Date
DE60106961D1 true DE60106961D1 (de) 2004-12-09
DE60106961T2 DE60106961T2 (de) 2005-11-24

Family

ID=9899649

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60106961T Expired - Lifetime DE60106961T2 (de) 2000-09-18 2001-09-17 Verfahren zur Herstellung von Clavulansäure

Country Status (9)

Country Link
US (1) US7087748B2 (de)
EP (1) EP1319086B1 (de)
JP (1) JP4944350B2 (de)
AT (1) ATE281530T1 (de)
AU (1) AU2001295569A1 (de)
DE (1) DE60106961T2 (de)
ES (1) ES2231558T3 (de)
GB (1) GB0022841D0 (de)
WO (1) WO2002022846A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4541715B2 (ja) * 2004-01-23 2010-09-08 北越紀州製紙株式会社 分子吸着機能を有するシート
CN101415808B (zh) * 2006-04-10 2011-10-05 R.J.雷诺兹烟草公司 从肉豆蔻油选择性除去黄樟素的方法
AU2010207887B2 (en) * 2009-01-29 2015-05-21 Commonwealth Scientific And Industrial Research Organisation Molecularly imprinted polymers

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
ES537158A0 (es) * 1984-10-27 1985-12-01 Antibioticos Sa Procedimiento para mejorar la extraccion del acido clavulanico
SE9102622L (sv) 1991-09-06 1993-03-07 Klaus Mosbach Saett att aastadkomma specifikt adsorptionsmaterial laempligt foer biologiska makromolekyler genom prearrangemang av immobiliserbara till makromolekylen i fraaga bindande funktionella grupper
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT404728B (de) 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
DK0867515T3 (da) 1997-03-24 2000-06-13 Cipan Comp Ind Prod Fremgangsmåde til isolering af et farmaceutisk acceptabelt alkalimetalsalt af clavulansyre
WO1998042858A1 (en) 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid

Also Published As

Publication number Publication date
WO2002022846A1 (en) 2002-03-21
EP1319086B1 (de) 2004-11-03
JP4944350B2 (ja) 2012-05-30
EP1319086A1 (de) 2003-06-18
DE60106961T2 (de) 2005-11-24
ES2231558T3 (es) 2005-05-16
JP2004509136A (ja) 2004-03-25
US7087748B2 (en) 2006-08-08
ATE281530T1 (de) 2004-11-15
AU2001295569A1 (en) 2002-03-26
GB0022841D0 (en) 2000-11-01
US20040063930A1 (en) 2004-04-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition