ATE280822T1 - Toleranzinduzierendes gewebekonstrukt und organ zusammengesetzt aus thymus und knochenmark - Google Patents

Toleranzinduzierendes gewebekonstrukt und organ zusammengesetzt aus thymus und knochenmark

Info

Publication number
ATE280822T1
ATE280822T1 AT01938113T AT01938113T ATE280822T1 AT E280822 T1 ATE280822 T1 AT E280822T1 AT 01938113 T AT01938113 T AT 01938113T AT 01938113 T AT01938113 T AT 01938113T AT E280822 T1 ATE280822 T1 AT E280822T1
Authority
AT
Austria
Prior art keywords
tolerance
tissue construct
thymus
bone marrow
organ
Prior art date
Application number
AT01938113T
Other languages
English (en)
Inventor
Philip Lake
Victor Chengwei Shi
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE280822T1 publication Critical patent/ATE280822T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22—Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/38—Stomach; Intestine; Goblet cells; Oral mucosa; Saliva
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/065—Thymocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1185—Thymus cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1394—Bone marrow stromal cells; whole marrow
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/25—Urinary tract cells, renal cells
    • C12N2502/256—Renal cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
AT01938113T 2000-04-17 2001-04-12 Toleranzinduzierendes gewebekonstrukt und organ zusammengesetzt aus thymus und knochenmark ATE280822T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55014400A 2000-04-17 2000-04-17
PCT/EP2001/004239 WO2001079452A2 (en) 2000-04-17 2001-04-12 Tolerance-inducing thy-marrow composite tissue construct and organ

Publications (1)

Publication Number Publication Date
ATE280822T1 true ATE280822T1 (de) 2004-11-15

Family

ID=24195928

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01938113T ATE280822T1 (de) 2000-04-17 2001-04-12 Toleranzinduzierendes gewebekonstrukt und organ zusammengesetzt aus thymus und knochenmark

Country Status (7)

Country Link
EP (2) EP1428872A3 (de)
JP (1) JP2004500914A (de)
AT (1) ATE280822T1 (de)
AU (1) AU2001263856A1 (de)
DE (1) DE60106748T2 (de)
ES (1) ES2231499T3 (de)
WO (1) WO2001079452A2 (de)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5658564A (en) * 1992-02-19 1997-08-19 The General Hospital Corporation Xenograft thymus
WO1996014853A1 (en) * 1994-11-10 1996-05-23 University Of Washington Intrathymic stem cell implantation

Also Published As

Publication number Publication date
EP1276851A2 (de) 2003-01-22
DE60106748D1 (de) 2004-12-02
AU2001263856A1 (en) 2001-10-30
WO2001079452A2 (en) 2001-10-25
EP1428872A3 (de) 2004-12-01
JP2004500914A (ja) 2004-01-15
EP1428872A2 (de) 2004-06-16
DE60106748T2 (de) 2005-10-27
EP1276851B1 (de) 2004-10-27
WO2001079452A3 (en) 2002-04-18
ES2231499T3 (es) 2005-05-16

Similar Documents

Publication Publication Date Title
EP1082057A4 (de) Biologisch modellierte implantierbare prothesen
BR0207722A (pt) Material compósito de enxerto de medula óssea, método de preparação do mesmo, e, kit para a preparação do mesmo
ATE424147T1 (de) Biotechnisch erzeugte gefässprothese für die implantation
ES2300276T3 (es) P40 de interleuquina-12 de mamifero e interleuquina b30. sus combinaciones. anticuerpos. usos en composiciones farmaceuticas.
AU5035998A (en) Enhancement of xenograft tolerance and porcine cytokines therefor
DE69940504D1 (de)
ATE270906T1 (de) Kieferknochen-transplantat aus natürlichem knochenmaterial
IL143326A0 (en) Method of cloning porcine animals
BR0208456A (pt) Métodos para cultura de circovìrus
CA2121370A1 (en) Specific tolerance in transplantation
DE69221368D1 (de) Osteogenische Wachstumsfaktoren zur Abgabe an Zielorgan
DE60141964D1 (de) Bandscheibe
AU6842001A (en) Pluripotent mammalian cells
DE69113746T2 (de) Teilweise zementierte Femurprothese.
EP2287290A3 (de) Nestin-Exprimierende Haarfollikel Stammzellen
AU2002323526A1 (en) Use of recipient endothelial cells for enhanced vascularization of tissue and tissue-engineered construct transplants
EP0700297A4 (de) Die erzeugung von toleranz gegen fremdtransplantaten durch tolerogenese mit hilfe von ersatzlebewesen
NO20031860D0 (no) Kahalaolid F
DE60235835D1 (de) Zellkulturmedien
DK1274464T3 (da) Sammensætninger og fremgangsmåder til regulering af proteinekspression i tarm
ATE280822T1 (de) Toleranzinduzierendes gewebekonstrukt und organ zusammengesetzt aus thymus und knochenmark
DK0853942T3 (da) Anvendelse og fremstilling af ikke-humant embryonisk metanephritisk væv
WO1999061589A3 (en) Expansion of hematopoietic stem cells transduced with mdr-1 and methods of use thereof
DK0772465T3 (da) Alginatfibre, fremstilling og anvendelse deraf
ATE361975T1 (de) Tiermodell für hepatitis-virus infektion

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1276851

Country of ref document: EP

REN Ceased due to non-payment of the annual fee