ATE277075T1 - Tripeptidische verbindungen mit wirksamkeit als selektive inhibitoren der aminopeptidase a und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Tripeptidische verbindungen mit wirksamkeit als selektive inhibitoren der aminopeptidase a und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE277075T1
ATE277075T1 AT00900616T AT00900616T ATE277075T1 AT E277075 T1 ATE277075 T1 AT E277075T1 AT 00900616 T AT00900616 T AT 00900616T AT 00900616 T AT00900616 T AT 00900616T AT E277075 T1 ATE277075 T1 AT E277075T1
Authority
AT
Austria
Prior art keywords
alkyl
cycloalkyl
group
heterocycloalkyl
aminoopeptidase
Prior art date
Application number
AT00900616T
Other languages
English (en)
Inventor
Bernard Roques
Marie-Claude Fournie-Zaluski
Laurent Bischoff
Christelle David-Basei
Catherine Llorens-Cortes
Original Assignee
Inst Nat Sante Rech Med
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med, Centre Nat Rech Scient filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of ATE277075T1 publication Critical patent/ATE277075T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00900616T 1999-01-20 2000-01-19 Tripeptidische verbindungen mit wirksamkeit als selektive inhibitoren der aminopeptidase a und sie enthaltende pharmazeutische zusammensetzungen ATE277075T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9900587A FR2788526B1 (fr) 1999-01-20 1999-01-20 Composes tripeptidiques utiles a titre d'hinhibiteurs selectifs de l'aminopeptidase a et compositions pharmaceutiques correspondantes
PCT/FR2000/000112 WO2000043414A1 (fr) 1999-01-20 2000-01-19 Composes tripeptidiques utiles a titre d'inhibiteurs selectifs de l'aminopeptidase a et compositions pharmaceutiques correspondantes

Publications (1)

Publication Number Publication Date
ATE277075T1 true ATE277075T1 (de) 2004-10-15

Family

ID=9541040

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900616T ATE277075T1 (de) 1999-01-20 2000-01-19 Tripeptidische verbindungen mit wirksamkeit als selektive inhibitoren der aminopeptidase a und sie enthaltende pharmazeutische zusammensetzungen

Country Status (8)

Country Link
US (1) US20020061840A1 (de)
EP (1) EP1140981B1 (de)
JP (1) JP2003506313A (de)
AT (1) ATE277075T1 (de)
CA (1) CA2359096A1 (de)
DE (1) DE60014029T2 (de)
FR (1) FR2788526B1 (de)
WO (1) WO2000043414A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777443B2 (en) 2001-05-15 2004-08-17 Novartis Ag Dipeptide derivatives
US20030165574A1 (en) * 2002-03-01 2003-09-04 Ward Loren Spencer Compositions and methods for treatment of body weight conditions
WO2005077401A1 (fr) * 2004-02-09 2005-08-25 Jianrong Miao Cardiotonique contenant un tripeptide ou un derive de celui-ci en tant qu'ingredient actif
KR100641076B1 (ko) 2004-08-27 2006-11-02 연세대학교 산학협력단 신규한 아미노펩티다아제 ｎ 억제제
WO2007141005A1 (en) * 2006-06-09 2007-12-13 Bayer Healthcare Ag Use of glutamyl aminopeptidase (enpep) as a therapeutic or diagnostic target
FR2931151A1 (fr) * 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
CN102171185A (zh) 2008-08-01 2011-08-31 拜奥西尼斯医药股份有限公司 甲硫氨酸类似物及其使用方法
WO2018151285A1 (ja) * 2017-02-20 2018-08-23 学校法人順天堂 掻痒性皮膚疾患の予防又は治療薬

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4636560A (en) * 1984-11-16 1987-01-13 E. R. Squibb & Sons, Inc. Amino thiol peptides
FR2770844A1 (fr) * 1997-11-10 1999-05-14 Inst Nat Sante Rech Med Inhibiteurs de toxines clostridiales et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
FR2788526B1 (fr) 2002-07-05
EP1140981B1 (de) 2004-09-22
CA2359096A1 (fr) 2000-07-27
EP1140981A1 (de) 2001-10-10
WO2000043414A1 (fr) 2000-07-27
DE60014029T2 (de) 2005-10-06
DE60014029D1 (de) 2004-10-28
US20020061840A1 (en) 2002-05-23
JP2003506313A (ja) 2003-02-18
FR2788526A1 (fr) 2000-07-21

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