ATE26215T1 - Steigerung der intranasalen absorption von calcitonin durch dessen formulierung mit oberflaechenaktiven mitteln. - Google Patents
Steigerung der intranasalen absorption von calcitonin durch dessen formulierung mit oberflaechenaktiven mitteln.Info
- Publication number
- ATE26215T1 ATE26215T1 AT83113070T AT83113070T ATE26215T1 AT E26215 T1 ATE26215 T1 AT E26215T1 AT 83113070 T AT83113070 T AT 83113070T AT 83113070 T AT83113070 T AT 83113070T AT E26215 T1 ATE26215 T1 AT E26215T1
- Authority
- AT
- Austria
- Prior art keywords
- surface active
- calcitonin
- formulating
- enhancement
- active agents
- Prior art date
Links
- 239000004094 surface-active agent Substances 0.000 title abstract 2
- 102000055006 Calcitonin Human genes 0.000 title 1
- 108060001064 Calcitonin Proteins 0.000 title 1
- 238000010521 absorption reaction Methods 0.000 title 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 title 1
- 229960004015 calcitonin Drugs 0.000 title 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000004097 bone metabolism Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45412882A | 1982-12-29 | 1982-12-29 | |
| EP83113070A EP0115627B1 (de) | 1982-12-29 | 1983-12-23 | Steigerung der intranasalen Absorption von Calcitonin durch dessen Formulierung mit oberflächenaktiven Mitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE26215T1 true ATE26215T1 (de) | 1987-04-15 |
Family
ID=23803421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83113070T ATE26215T1 (de) | 1982-12-29 | 1983-12-23 | Steigerung der intranasalen absorption von calcitonin durch dessen formulierung mit oberflaechenaktiven mitteln. |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0115627B1 (de) |
| JP (1) | JPS59130820A (de) |
| AT (1) | ATE26215T1 (de) |
| AU (1) | AU572815B2 (de) |
| CA (1) | CA1222948A (de) |
| DE (1) | DE3370586D1 (de) |
| DK (1) | DK602783A (de) |
| IE (1) | IE56441B1 (de) |
| IL (1) | IL70489A0 (de) |
| MX (1) | MX7547E (de) |
| NZ (1) | NZ206728A (de) |
| PH (1) | PH20444A (de) |
| ZA (1) | ZA839655B (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH657779A5 (de) * | 1982-10-05 | 1986-09-30 | Sandoz Ag | Galenische zusammensetzungen enthaltend calcitonin. |
| BE897904A (fr) * | 1982-10-05 | 1984-04-04 | Sandoz Sa | Nouvelles compositions galeniques a base de calcitonine |
| GB8514090D0 (en) * | 1985-06-04 | 1985-07-10 | Sandoz Ltd | Organic compounds |
| JPS61267528A (ja) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
| JPS61194034A (ja) * | 1985-02-25 | 1986-08-28 | Teijin Ltd | 経鼻投与用粉末状組成物 |
| JPH0651637B2 (ja) * | 1985-03-28 | 1994-07-06 | エーザイ株式会社 | ペプタイドの吸着防止組成物 |
| GB2177914B (en) * | 1985-06-04 | 1989-10-25 | Chugai Pharmaceutical Co Ltd | A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia |
| US4731360A (en) * | 1985-08-16 | 1988-03-15 | Merck & Co., Inc. | Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments |
| US4692441A (en) * | 1985-08-16 | 1987-09-08 | Merck & Co., Inc. | Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities |
| DE3601923A1 (de) * | 1986-01-23 | 1987-07-30 | Behringwerke Ag | Nasal applizierbares arzneimittel, verfahren zu seiner herstellung und seine verwendung |
| CA1291036C (en) * | 1986-04-23 | 1991-10-22 | Edwin I. Stoltz | Nasal administration of drugs |
| MY102411A (en) * | 1986-12-23 | 1992-06-17 | Ciba Geigy Ag | Nasal solutions |
| WO1988004926A1 (en) * | 1987-01-08 | 1988-07-14 | Nastech Pharmaceutical Company, Inc. | Nasal delivery of amino acids |
| HU203204B (en) * | 1987-09-15 | 1991-06-28 | Sandoz Ag | Process for producing suppository containing calcitonin and taurocholic acid |
| ES2061688T3 (es) * | 1987-11-13 | 1994-12-16 | Smithkline Beecham Farma | Composiciones farmaceuticas que comprenden una calcitonina y un glicirricinato como mejorador de la absorcion. |
| HU206367B (en) * | 1988-04-30 | 1992-10-28 | Sandoz Ag | Process for producing acid addition salts of steroid carboxylic acid-amidated taurine and glycine, as well as pharmaceutical compositions comprising such salts |
| GR880100604A (el) * | 1988-09-14 | 1994-03-31 | Sandoz Ag | Βελτιώσεις σε ή σχετικά με καλσιτονίνες. |
| US5514365A (en) * | 1988-10-11 | 1996-05-07 | Schiapparelli Salute S.P.A. | Pharmaceutical compositions comprising calcitonin for intranasal administration |
| US5182258A (en) * | 1989-03-20 | 1993-01-26 | Orbon Corporation | Systemic delivery of polypeptides through the eye |
| IT8920486A0 (it) * | 1989-05-12 | 1989-05-12 | Isf Spa | Composizioni farmaceutiche. |
| JP2514249B2 (ja) * | 1989-05-23 | 1996-07-10 | 帝人株式会社 | 安定化されたカルシトニン類医薬組成物 |
| JP2911496B2 (ja) * | 1989-09-11 | 1999-06-23 | 帝國製薬株式会社 | 生理活性ポリペプチド含有高吸収性経膣剤 |
| JPH0643339B2 (ja) * | 1990-05-25 | 1994-06-08 | 旭化成工業株式会社 | カルシトニン類水溶液組成物の安定化法 |
| JPH078806B2 (ja) * | 1990-08-16 | 1995-02-01 | 旭化成工業株式会社 | カルシトニン類含有経鼻投与用乳剤 |
| IT1242019B (it) * | 1990-11-20 | 1994-02-02 | Ripari Gero Ist Farm Biolog | Composizioni farmaceutiche acquose a base di calcitonina, da somministrarsi per via nasale. |
| DE4222647A1 (de) * | 1991-07-15 | 1993-01-21 | Sandoz Ag | Peptid-zubereitungen |
| JPH06305952A (ja) * | 1993-04-27 | 1994-11-01 | Sumitomo Pharmaceut Co Ltd | スレオ−３−（３，４−ジヒドロキシフェニル）セリン経鼻投与製剤 |
| US5744155A (en) * | 1993-08-13 | 1998-04-28 | Friedman; Doron | Bioadhesive emulsion preparations for enhanced drug delivery |
| US5514670A (en) * | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
| JPH11292787A (ja) * | 1995-08-15 | 1999-10-26 | Asahi Chem Ind Co Ltd | 生理活性ペプチドを含有する経粘膜投与製剤 |
| IT1282374B1 (it) * | 1996-01-31 | 1998-03-20 | Therapicon Srl | Composizioni farmaceutiche parenterali a base di calcitonine sintetiche a ph controllato con basso indice di dolorosita' |
| WO1998046269A1 (en) | 1997-04-14 | 1998-10-22 | Tt Pharmaceuticals, Inc. | Permucous preparation |
| TWI243687B (en) | 1998-04-21 | 2005-11-21 | Teijin Ltd | Pharmaceutical composition for application to mucosa |
| JP2000247911A (ja) | 1999-02-26 | 2000-09-12 | Hisamitsu Pharmaceut Co Inc | 大腸用吸収促進剤 |
| AR026073A1 (es) | 1999-10-20 | 2002-12-26 | Nycomed Gmbh | Composicion farmaceutica acuosa que contiene ciclesonida |
| CN1183965C (zh) | 2000-02-04 | 2005-01-12 | 尤尼金实验室公司 | 鼻内降钙素制剂 |
| JP4493594B2 (ja) | 2003-03-04 | 2010-06-30 | 田辺三菱製薬株式会社 | 粉末経鼻投与製剤 |
| WO2004084859A2 (en) | 2003-03-21 | 2004-10-07 | Nastech Pharmaceutical Company Inc. | Nasal calcitonin formulations containing chlorobutanol |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2254061A1 (de) * | 1972-11-04 | 1974-05-16 | Hoechst Ag | Lh-releasing hormon zur nasalen applikation |
| CA1098444A (en) * | 1975-05-26 | 1981-03-31 | Leo Geller | Peptide preparations with prolonged action |
| GB1527605A (en) * | 1975-08-20 | 1978-10-04 | Takeda Chemical Industries Ltd | Insulin preparation for intranasal administration |
| US4241051A (en) * | 1977-11-04 | 1980-12-23 | Christie Robert B | Calcitonin |
| JPS56122309A (en) * | 1980-03-03 | 1981-09-25 | Teijin Ltd | Calcitonin pharmaceutical for rectal administration |
| AU538311B2 (en) * | 1981-01-02 | 1984-08-09 | Aktien Henkel Kommanditgesellschaft Auf | Treatment of disorders of calcium metabolism |
| CH657779A5 (de) * | 1982-10-05 | 1986-09-30 | Sandoz Ag | Galenische zusammensetzungen enthaltend calcitonin. |
| BE897904A (fr) * | 1982-10-05 | 1984-04-04 | Sandoz Sa | Nouvelles compositions galeniques a base de calcitonine |
-
1983
- 1983-12-20 IL IL70489A patent/IL70489A0/xx unknown
- 1983-12-20 AU AU22596/83A patent/AU572815B2/en not_active Ceased
- 1983-12-22 CA CA000444099A patent/CA1222948A/en not_active Expired
- 1983-12-23 DE DE8383113070T patent/DE3370586D1/de not_active Expired
- 1983-12-23 EP EP83113070A patent/EP0115627B1/de not_active Expired
- 1983-12-23 AT AT83113070T patent/ATE26215T1/de not_active IP Right Cessation
- 1983-12-26 MX MX8310951U patent/MX7547E/es unknown
- 1983-12-27 JP JP58244931A patent/JPS59130820A/ja active Pending
- 1983-12-28 ZA ZA839655A patent/ZA839655B/xx unknown
- 1983-12-28 DK DK602783A patent/DK602783A/da not_active Application Discontinuation
- 1983-12-29 PH PH30054A patent/PH20444A/en unknown
- 1983-12-29 IE IE3071/83A patent/IE56441B1/xx unknown
-
1984
- 1984-01-05 NZ NZ206728A patent/NZ206728A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK602783A (da) | 1984-06-30 |
| EP0115627B1 (de) | 1987-04-01 |
| IE56441B1 (en) | 1991-07-31 |
| PH20444A (en) | 1987-01-09 |
| AU572815B2 (en) | 1988-05-19 |
| MX7547E (es) | 1989-09-14 |
| EP0115627A1 (de) | 1984-08-15 |
| JPS59130820A (ja) | 1984-07-27 |
| ZA839655B (en) | 1984-08-29 |
| DK602783D0 (da) | 1983-12-28 |
| IE833071L (en) | 1984-06-29 |
| IL70489A0 (en) | 1984-03-30 |
| NZ206728A (en) | 1986-02-21 |
| DE3370586D1 (en) | 1987-05-07 |
| AU2259683A (en) | 1984-07-05 |
| CA1222948A (en) | 1987-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |