ATE25679T1 - Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung. - Google Patents

Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.

Info

Publication number
ATE25679T1
ATE25679T1 AT83108697T AT83108697T ATE25679T1 AT E25679 T1 ATE25679 T1 AT E25679T1 AT 83108697 T AT83108697 T AT 83108697T AT 83108697 T AT83108697 T AT 83108697T AT E25679 T1 ATE25679 T1 AT E25679T1
Authority
AT
Austria
Prior art keywords
compounds
processes
production
pharmaceutical preparations
preparations based
Prior art date
Application number
AT83108697T
Other languages
German (de)
English (en)
Inventor
Elmar Dr Konz
Joachim Dr Kaiser
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of ATE25679T1 publication Critical patent/ATE25679T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT83108697T 1982-09-09 1983-09-03 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung. ATE25679T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823233424 DE3233424A1 (de) 1982-09-09 1982-09-09 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
EP83108697A EP0105210B1 (de) 1982-09-09 1983-09-03 Isochinolinderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate auf Basis dieser Verbindungen und ihre Verwendung

Publications (1)

Publication Number Publication Date
ATE25679T1 true ATE25679T1 (de) 1987-03-15

Family

ID=6172780

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83108697T ATE25679T1 (de) 1982-09-09 1983-09-03 Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung.

Country Status (19)

Country Link
US (1) US4673682A (instruction)
EP (1) EP0105210B1 (instruction)
JP (1) JPS5967270A (instruction)
KR (1) KR840006206A (instruction)
AT (1) ATE25679T1 (instruction)
AU (1) AU1891683A (instruction)
CA (1) CA1211445A (instruction)
DE (2) DE3233424A1 (instruction)
DK (1) DK408083A (instruction)
ES (1) ES8404852A1 (instruction)
FI (1) FI833200A7 (instruction)
GR (1) GR79382B (instruction)
HU (1) HU191094B (instruction)
IL (1) IL69683A0 (instruction)
NO (1) NO833217L (instruction)
NZ (1) NZ205513A (instruction)
PH (1) PH18186A (instruction)
PT (1) PT77309B (instruction)
ZA (1) ZA836663B (instruction)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
ES2152938T3 (es) * 1992-09-28 2001-02-16 Hoechst Ag 1(2h)-isoquinolinas sustituidas antiarritmicas y cardioprotectoras, procedimiento para su produccion, medicamento que las contiene y su uso para la produccion de un medicamento para combatir fallos cardiacos.
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
NZ543448A (en) * 2003-06-06 2009-02-28 Fibrogen Inc Nitrogen-containing heteroaryl compounds and their use in increasing endogeneous erythropoietin
CN103382216B (zh) * 2006-01-27 2016-04-20 菲布罗根有限公司 使低氧诱导因子（hif）稳定的氰基异喹啉化合物
US7696223B2 (en) * 2006-04-04 2010-04-13 Fibrogen, Inc. Pyrrolo- and Thiazolo-pyridine compounds, and methods of use thereof
US8927591B2 (en) 2008-11-14 2015-01-06 Fibrogen, Inc. Thiochromene derivatives as HIF hydroxylase inhibitors
AU2013229922B2 (en) 2012-03-09 2017-09-28 Fibrogen, Inc. 4 -hydroxy- isoquinoline compounds as HIF hydroxylase inhibitors
US8883823B2 (en) 2012-07-16 2014-11-11 Fibrogen, Inc. Crystalline forms of a prolyl hydroxylase inhibitor
KR20210130849A (ko) 2012-07-16 2021-11-01 피브로겐, 인크. 프롤릴 하이드록실라제 억제제 [(4-하이드록시-1-메틸-7-페녹시-아이소퀴놀린-3-카보닐)-아미노]-아세트산의 결정형
US9340511B2 (en) 2012-07-16 2016-05-17 Fibrogen, Inc. Process for making isoquinoline compounds
WO2014116849A1 (en) 2013-01-24 2014-07-31 Fibrogen, Inc. Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2054482B1 (instruction) * 1969-07-11 1973-06-08 Anvar
FR2424270A1 (fr) * 1978-04-24 1979-11-23 Rhone Poulenc Ind Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent
DE2818423A1 (de) * 1978-04-27 1979-11-08 Hoechst Ag Neue isochinolinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0105210A3 (en) 1984-10-10
KR840006206A (ko) 1984-11-22
IL69683A0 (en) 1983-12-30
AU1891683A (en) 1984-03-15
DE3369983D1 (en) 1987-04-09
FI833200A7 (fi) 1984-03-10
PT77309B (de) 1986-04-18
FI833200A0 (fi) 1983-09-07
DK408083D0 (da) 1983-09-08
ES525441A0 (es) 1984-05-16
JPS5967270A (ja) 1984-04-16
ZA836663B (en) 1984-04-25
CA1211445A (en) 1986-09-16
PT77309A (de) 1983-10-01
HU191094B (en) 1987-01-28
DK408083A (da) 1984-03-10
DE3233424A1 (de) 1984-03-15
GR79382B (instruction) 1984-10-22
ES8404852A1 (es) 1984-05-16
NZ205513A (en) 1986-05-09
US4673682A (en) 1987-06-16
NO833217L (no) 1984-03-12
EP0105210A2 (de) 1984-04-11
EP0105210B1 (de) 1987-03-04
PH18186A (en) 1985-04-12

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