ATE255115T1 - Robustaflavone, zwischenprodukte und ähnliche verbindungen und verfahren zu deren herstellung - Google Patents
Robustaflavone, zwischenprodukte und ähnliche verbindungen und verfahren zu deren herstellungInfo
- Publication number
- ATE255115T1 ATE255115T1 AT98944520T AT98944520T ATE255115T1 AT E255115 T1 ATE255115 T1 AT E255115T1 AT 98944520 T AT98944520 T AT 98944520T AT 98944520 T AT98944520 T AT 98944520T AT E255115 T1 ATE255115 T1 AT E255115T1
- Authority
- AT
- Austria
- Prior art keywords
- robustaflavone
- apigenin
- analogues
- aflavones
- robust
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- BORWSEZUWHQTOK-UHFFFAOYSA-N robustaflavone Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C(C=3C(=CC=C(C=3)C=3OC4=CC(O)=CC(O)=C4C(=O)C=3)O)=C(O)C=C2O1 BORWSEZUWHQTOK-UHFFFAOYSA-N 0.000 abstract 6
- 229940117893 apigenin Drugs 0.000 abstract 2
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 abstract 2
- 235000008714 apigenin Nutrition 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- VTMYAMANLDGIMR-QFIPXVFZSA-N Rhusflavone Natural products O=C1c2c(O)cc(O)c(-c3c(O)c4C(=O)C[C@@H](c5ccc(O)cc5)Oc4cc3O)c2OC(c2ccc(O)cc2)=C1 VTMYAMANLDGIMR-QFIPXVFZSA-N 0.000 abstract 1
- 238000006069 Suzuki reaction reaction Methods 0.000 abstract 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001472 apigenin derivatives Chemical class 0.000 abstract 1
- -1 apigenin ethers Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- ZOCHARZZJNPSEU-UHFFFAOYSA-N diboron Chemical compound B#B ZOCHARZZJNPSEU-UHFFFAOYSA-N 0.000 abstract 1
- 230000026045 iodination Effects 0.000 abstract 1
- 238000006192 iodination reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/22—Tin compounds
- C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5713197P | 1997-08-28 | 1997-08-28 | |
| US8169998P | 1998-04-14 | 1998-04-14 | |
| US09/137,767 US6225481B1 (en) | 1997-08-28 | 1998-08-21 | Robustaflavone, intermediates and analogues and method for preparation thereof |
| PCT/US1998/017590 WO1999010292A2 (en) | 1997-08-28 | 1998-08-21 | Robustaflavone, intermediates and analogues and method for preparation thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE255115T1 true ATE255115T1 (de) | 2003-12-15 |
Family
ID=27369169
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98944520T ATE255115T1 (de) | 1997-08-28 | 1998-08-21 | Robustaflavone, zwischenprodukte und ähnliche verbindungen und verfahren zu deren herstellung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6225481B1 (de) |
| EP (1) | EP1007528B1 (de) |
| JP (1) | JP2001514156A (de) |
| CN (1) | CN1274354A (de) |
| AT (1) | ATE255115T1 (de) |
| AU (1) | AU744173B2 (de) |
| DE (1) | DE69820069D1 (de) |
| WO (1) | WO1999010292A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100579974C (zh) * | 2004-12-31 | 2010-01-13 | 台盐实业股份有限公司 | 罗汉松属萃取物及其制造方法 |
| LV13736B (en) * | 2006-12-28 | 2008-09-20 | Vjaceslavs Tribulovics | Method for manufacturing 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphtoic acid |
| JP4559531B1 (ja) * | 2009-12-03 | 2010-10-06 | ウシオケミックス株式会社 | ノビレチンの製造方法 |
| CN102558127B (zh) * | 2011-12-15 | 2014-04-02 | 江南大学 | 一种微波辅助合成多羟基黄酮化合物的方法 |
| CN103087025A (zh) * | 2013-02-22 | 2013-05-08 | 天津科技大学 | 次生代谢活性成分穗花杉双黄酮的全合成方法 |
-
1998
- 1998-08-21 US US09/137,767 patent/US6225481B1/en not_active Expired - Fee Related
- 1998-08-21 WO PCT/US1998/017590 patent/WO1999010292A2/en not_active Ceased
- 1998-08-21 DE DE69820069T patent/DE69820069D1/de not_active Expired - Lifetime
- 1998-08-21 AT AT98944520T patent/ATE255115T1/de not_active IP Right Cessation
- 1998-08-21 CN CN98809992A patent/CN1274354A/zh active Pending
- 1998-08-21 EP EP98944520A patent/EP1007528B1/de not_active Expired - Lifetime
- 1998-08-21 AU AU92046/98A patent/AU744173B2/en not_active Ceased
- 1998-08-21 JP JP2000507626A patent/JP2001514156A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1007528B1 (de) | 2003-11-26 |
| WO1999010292A3 (en) | 1999-06-17 |
| WO1999010292A2 (en) | 1999-03-04 |
| EP1007528A2 (de) | 2000-06-14 |
| CN1274354A (zh) | 2000-11-22 |
| AU9204698A (en) | 1999-03-16 |
| AU744173B2 (en) | 2002-02-14 |
| US6225481B1 (en) | 2001-05-01 |
| JP2001514156A (ja) | 2001-09-11 |
| DE69820069D1 (de) | 2004-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |