ATE231493T1 - Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung - Google Patents

Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung

Info

Publication number
ATE231493T1
ATE231493T1 AT95927269T AT95927269T ATE231493T1 AT E231493 T1 ATE231493 T1 AT E231493T1 AT 95927269 T AT95927269 T AT 95927269T AT 95927269 T AT95927269 T AT 95927269T AT E231493 T1 ATE231493 T1 AT E231493T1
Authority
AT
Austria
Prior art keywords
alkaloids
arylisoqhinoline
dimere
production
present
Prior art date
Application number
AT95927269T
Other languages
English (en)
Inventor
Gerhard Bringmann
Michael R Boyd
Roland Gotz
T Ross Kelly
Original Assignee
Us Health
Trustees Boston College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/279,291 external-priority patent/US5552550A/en
Priority claimed from US08/279,339 external-priority patent/US5571919A/en
Application filed by Us Health, Trustees Boston College filed Critical Us Health
Application granted granted Critical
Publication of ATE231493T1 publication Critical patent/ATE231493T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT95927269T 1994-07-22 1995-07-19 Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung ATE231493T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/279,291 US5552550A (en) 1994-07-22 1994-07-22 Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US08/279,339 US5571919A (en) 1994-07-22 1994-07-22 Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
US30521194A 1994-09-13 1994-09-13
US08/363,684 US5578729A (en) 1994-07-22 1994-12-23 Dimeric arylisoquinoline alkaloid compounds
PCT/US1995/009070 WO1996003381A1 (en) 1994-07-22 1995-07-19 Dimeric arylisoquinoline alkaloids and synthesis methods thereof

Publications (1)

Publication Number Publication Date
ATE231493T1 true ATE231493T1 (de) 2003-02-15

Family

ID=27501247

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927269T ATE231493T1 (de) 1994-07-22 1995-07-19 Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung

Country Status (10)

Country Link
US (2) US5578729A (de)
EP (1) EP0775115B1 (de)
JP (1) JPH10506377A (de)
AT (1) ATE231493T1 (de)
AU (1) AU699121B2 (de)
CA (1) CA2195646A1 (de)
DE (1) DE69529464T2 (de)
DK (1) DK0775115T3 (de)
ES (1) ES2191056T3 (de)
WO (1) WO1996003381A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578729A (en) * 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
US5639761A (en) 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US6140339A (en) 1994-02-14 2000-10-31 The United States Of America As Represented By The Department Of Health And Human Services Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
US7402594B2 (en) * 2003-05-19 2008-07-22 Virginia Commonwealth University Sulfated bis-cyclic agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH541609A (de) * 1970-02-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen
US4096190A (en) * 1976-11-26 1978-06-20 Ici Americas Inc. Oxidative coupling of alkylphenols catalyzed by metal ammonia complexes
JPS5646923A (en) * 1979-12-24 1981-04-28 Sanyo Electric Co Ltd Fuel control circuit for liquid combustor
DE69232417T2 (de) * 1991-04-12 2002-10-24 The United States Of America, Represented By The Secretary Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren
DE4117080A1 (de) * 1991-05-25 1992-11-26 Basf Ag Anwendung von dioncophyllinen als fungizide
JP3093008B2 (ja) * 1991-11-29 2000-10-03 オリンパス光学工業株式会社 レボルバ回転駆動装置
WO1994024108A1 (en) * 1993-04-19 1994-10-27 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Michellamines useful as antiviral agents
US5578729A (en) * 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
US5639761A (en) * 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US5552550A (en) * 1994-07-22 1996-09-03 The United States Of America, As Represented By The Department Of Health And Human Services Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US5409938A (en) * 1994-02-14 1995-04-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof
US5571919A (en) * 1994-07-22 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof

Also Published As

Publication number Publication date
JPH10506377A (ja) 1998-06-23
AU699121B2 (en) 1998-11-26
US5786482A (en) 1998-07-28
WO1996003381A1 (en) 1996-02-08
AU3135195A (en) 1996-02-22
CA2195646A1 (en) 1996-02-08
ES2191056T3 (es) 2003-09-01
DE69529464D1 (de) 2003-02-27
EP0775115B1 (de) 2003-01-22
DE69529464T2 (de) 2003-10-30
EP0775115A1 (de) 1997-05-28
US5578729A (en) 1996-11-26
DK0775115T3 (da) 2003-05-26

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