DE69529464T2 - Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung - Google Patents

Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung

Info

Publication number
DE69529464T2
DE69529464T2 DE69529464T DE69529464T DE69529464T2 DE 69529464 T2 DE69529464 T2 DE 69529464T2 DE 69529464 T DE69529464 T DE 69529464T DE 69529464 T DE69529464 T DE 69529464T DE 69529464 T2 DE69529464 T2 DE 69529464T2
Authority
DE
Germany
Prior art keywords
alkaloids
arylisoqhinoline
dimere
production
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69529464T
Other languages
English (en)
Other versions
DE69529464D1 (de
Inventor
Gerhard Bringmann
R Boyd
Roland Gotz
Ross Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Health and Human Services
Boston College
Original Assignee
US Department of Health and Human Services
Boston College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/279,291 external-priority patent/US5552550A/en
Priority claimed from US08/279,339 external-priority patent/US5571919A/en
Application filed by US Department of Health and Human Services, Boston College filed Critical US Department of Health and Human Services
Application granted granted Critical
Publication of DE69529464D1 publication Critical patent/DE69529464D1/de
Publication of DE69529464T2 publication Critical patent/DE69529464T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE69529464T 1994-07-22 1995-07-19 Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung Expired - Fee Related DE69529464T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/279,291 US5552550A (en) 1994-07-22 1994-07-22 Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US08/279,339 US5571919A (en) 1994-07-22 1994-07-22 Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof
US30521194A 1994-09-13 1994-09-13
US08/363,684 US5578729A (en) 1994-07-22 1994-12-23 Dimeric arylisoquinoline alkaloid compounds
PCT/US1995/009070 WO1996003381A1 (en) 1994-07-22 1995-07-19 Dimeric arylisoquinoline alkaloids and synthesis methods thereof

Publications (2)

Publication Number Publication Date
DE69529464D1 DE69529464D1 (de) 2003-02-27
DE69529464T2 true DE69529464T2 (de) 2003-10-30

Family

ID=27501247

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529464T Expired - Fee Related DE69529464T2 (de) 1994-07-22 1995-07-19 Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung

Country Status (10)

Country Link
US (2) US5578729A (de)
EP (1) EP0775115B1 (de)
JP (1) JPH10506377A (de)
AT (1) ATE231493T1 (de)
AU (1) AU699121B2 (de)
CA (1) CA2195646A1 (de)
DE (1) DE69529464T2 (de)
DK (1) DK0775115T3 (de)
ES (1) ES2191056T3 (de)
WO (1) WO1996003381A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639761A (en) 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US6140339A (en) * 1994-02-14 2000-10-31 The United States Of America As Represented By The Department Of Health And Human Services Monomeric and dimeric arylisoquinoline alkaloids and derivatives thereof
US5578729A (en) * 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
US7402594B2 (en) * 2003-05-19 2008-07-22 Virginia Commonwealth University Sulfated bis-cyclic agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH541609A (de) * 1970-02-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung von Bi-isochinolinonen und deren Verwendung als Fluoreszenzfarbstoffe in Kunststoffen
US4096190A (en) * 1976-11-26 1978-06-20 Ici Americas Inc. Oxidative coupling of alkylphenols catalyzed by metal ammonia complexes
JPS5646923A (en) * 1979-12-24 1981-04-28 Sanyo Electric Co Ltd Fuel control circuit for liquid combustor
ATE213231T1 (de) * 1991-04-12 2002-02-15 Us Secretary United States Dep Michellamine zur verwendung als antivirale wirkstoffe, zusammensetzung und behandlungsverfahren
DE4117080A1 (de) * 1991-05-25 1992-11-26 Basf Ag Anwendung von dioncophyllinen als fungizide
JP3093008B2 (ja) * 1991-11-29 2000-10-03 オリンパス光学工業株式会社 レボルバ回転駆動装置
WO1994024108A1 (en) * 1993-04-19 1994-10-27 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Michellamines useful as antiviral agents
US5639761A (en) * 1994-02-14 1997-06-17 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antimalarial naphthylisoquinoline alkaloids and pharmaceutical compositions and medical uses thereof
US5578729A (en) * 1994-07-22 1996-11-26 The United States Of America As Represented By The Department Of Health And Human Services Dimeric arylisoquinoline alkaloid compounds
US5552550A (en) * 1994-07-22 1996-09-03 The United States Of America, As Represented By The Department Of Health And Human Services Monomeric Naphthylisoquinoline alkaloids and synthesis methods thereof
US5409938A (en) * 1994-02-14 1995-04-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof
US5571919A (en) * 1994-07-22 1996-11-05 The United States Of America As Represented By The Department Of Health And Human Services Dimeric naphthylisoquinoline alkaloids and synthesis methods thereof

Also Published As

Publication number Publication date
ES2191056T3 (es) 2003-09-01
US5578729A (en) 1996-11-26
WO1996003381A1 (en) 1996-02-08
DE69529464D1 (de) 2003-02-27
EP0775115B1 (de) 2003-01-22
JPH10506377A (ja) 1998-06-23
AU699121B2 (en) 1998-11-26
ATE231493T1 (de) 2003-02-15
CA2195646A1 (en) 1996-02-08
AU3135195A (en) 1996-02-22
EP0775115A1 (de) 1997-05-28
DK0775115T3 (da) 2003-05-26
US5786482A (en) 1998-07-28

Similar Documents

Publication Publication Date Title
ATA312987A (de) Brenzkatechin-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneistoffe
DE69819699D1 (de) Verfahren zur Herstellung von multiaxialen Vliesstoffen
DE3683466D1 (de) Verfahren zur kontinuierlichen herstellung von propylen-ethylen-blockcopolymeren.
ATA376284A (de) Verfahren zur herstellung von neuen 2,6-disubstituierten naphthalin-derivaten
DE3582110D1 (de) Verdickungsmittel, verfahren zur herstellung und ihre verwendung.
LU80601A1 (de) Neue kondensierte pyrimidin-derivate und verfahren zu ihrer herstellung
DE3581090D1 (de) 1-cyclopropyl-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carbonsaeure, ihre derivate und verfahren zu ihrer herstellung.
ATE231493T1 (de) Dimere arylisoqhinoline alkaloide und verfahren zu deren herstellung
ATE38512T1 (de) Phenylen-substituierte, spergualinaehnliche derivate, verfahren zu ihrer herstellung und ihre verwendung als heilmittel.
ATA50989A (de) Antiviral und immunstimulierend wirkende neue salze, sowie verfahren zu deren herstellung und verwendung der salze
DE3680227D1 (de) N-cyklohexyl-polycarboxamide verbindung und ihre derivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von acceptor-donor-komplexen.
ATE10739T1 (de) Substituierte heterocyclische phenoxyamine, verfahren zu ihrer herstellung und ihre verwendung als mittel fuer lokale anaesthesie.
DE3586324D1 (de) Tetrahydrophthalimidderivate, verfahren zu ihrer herstellung und ihre verwendung.
ATA218185A (de) Verfahren zur herstellung von neuen 6-substituierten mitomycinderivaten
AT399880B (de) Neue thienothiazinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3780417D1 (de) Verfahren zur verminderung der breite von brammen.
FI870315A0 (fi) Välituotteita -laktaami-yhdisteiden sekä 1 -metyylikarbapeneemi-yhdisteiden synteeseissä, ja näiden valmistusmenetelmä
DE3667657D1 (de) N-substituierte glutaminsaeurederivate, verfahren zu ihrer herstellung und ihre verwendung.
DE3575002D1 (de) Verfahren zur herstellung von filzfest ausgeruesteter, gegebenenfalls gefaerbter wolle.
AT382377B (de) Verfahren zur herstellung von neuen 7-substituierten aminopyrazolo(4,3-b)pyridinen
ATA257987A (de) Urdamycin g und dessen derivate, verfahren zu ihrer herstellung und ihre verwendung
ATE236127T1 (de) Monomer und dimer naphthylisochinoline alkaloide und verfahren zu deren synthese
ATA8088A (de) Verfahren zur herstellung von neuen 6-substituierten mitomycinderivaten
AT358198B (de) Verfahren zur herstellung von neuen pyrimidin- -derivaten
ATE45158T1 (de) Neue 12-amino-pyridazino(4',5':3,4>pyrrolo-(2,1a>isochinoline, verfahren zu ihrer herstellung und ihre verwendung.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee