ATE236192T1 - 3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften - Google Patents
3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaftenInfo
- Publication number
- ATE236192T1 ATE236192T1 AT96943062T AT96943062T ATE236192T1 AT E236192 T1 ATE236192 T1 AT E236192T1 AT 96943062 T AT96943062 T AT 96943062T AT 96943062 T AT96943062 T AT 96943062T AT E236192 T1 ATE236192 T1 AT E236192T1
- Authority
- AT
- Austria
- Prior art keywords
- amidino
- aminoethyl
- arginine mimetic
- mimetic properties
- derivatives
- Prior art date
Links
- YDRVFCVPWICTOV-UHFFFAOYSA-N 3-(2-aminoethyl)-2,5-dihydropyrrole-1-carboximidamide Chemical class NCCC1=CCN(C(N)=N)C1 YDRVFCVPWICTOV-UHFFFAOYSA-N 0.000 title 1
- 239000004475 Arginine Substances 0.000 title 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 title 1
- MJSQLVQCYKAPNT-UHFFFAOYSA-N 2,3-dihydropyrrole-1-carboximidamide Chemical class NC(=N)N1CCC=C1 MJSQLVQCYKAPNT-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19546018 | 1995-12-09 | ||
DE19614179 | 1996-04-11 | ||
PCT/EP1996/005494 WO1997021725A1 (en) | 1995-12-09 | 1996-12-09 | 3-aminoethyl-n-amidino-2,5-dihydropyrrole derivatives having arginine mimetic properties |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE236192T1 true ATE236192T1 (de) | 2003-04-15 |
Family
ID=26021108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96943062T ATE236192T1 (de) | 1995-12-09 | 1996-12-09 | 3-aminoethyl-n-amidino-2,5-dihydropyrrol derivative mit arginine-mimetischen eigenschaften |
Country Status (9)
Country | Link |
---|---|
US (1) | US20020026034A1 (de) |
EP (1) | EP0865445B1 (de) |
JP (1) | JP2000502078A (de) |
AT (1) | ATE236192T1 (de) |
AU (1) | AU1192097A (de) |
CA (1) | CA2239908A1 (de) |
DE (1) | DE69627184D1 (de) |
TW (1) | TW455580B (de) |
WO (1) | WO1997021725A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0902036A1 (de) * | 1997-09-05 | 1999-03-17 | Roche Diagnostics GmbH | Peptide mit einem Arginine-Substitut für die Behandlung von Osteoporosis, deren Herstellung und diese enthaltende Verbindungen |
US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
CN117164932B (zh) * | 2023-10-31 | 2024-01-26 | 汕头市虹桥包装实业有限公司 | 一种注塑发泡聚丙烯材料及其制备方法和在轻量化高性能瓶盖中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
SE9301912D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | Process for the production of aminoalkylguandines |
-
1996
- 1996-12-09 EP EP96943062A patent/EP0865445B1/de not_active Expired - Lifetime
- 1996-12-09 US US09/077,879 patent/US20020026034A1/en not_active Abandoned
- 1996-12-09 WO PCT/EP1996/005494 patent/WO1997021725A1/en active IP Right Grant
- 1996-12-09 AU AU11920/97A patent/AU1192097A/en not_active Abandoned
- 1996-12-09 TW TW085115198A patent/TW455580B/zh not_active IP Right Cessation
- 1996-12-09 AT AT96943062T patent/ATE236192T1/de not_active IP Right Cessation
- 1996-12-09 DE DE69627184T patent/DE69627184D1/de not_active Expired - Lifetime
- 1996-12-09 CA CA002239908A patent/CA2239908A1/en not_active Abandoned
- 1996-12-09 JP JP09521726A patent/JP2000502078A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20020026034A1 (en) | 2002-02-28 |
AU1192097A (en) | 1997-07-03 |
CA2239908A1 (en) | 1997-06-19 |
EP0865445B1 (de) | 2003-04-02 |
TW455580B (en) | 2001-09-21 |
WO1997021725A1 (en) | 1997-06-19 |
EP0865445A1 (de) | 1998-09-23 |
JP2000502078A (ja) | 2000-02-22 |
DE69627184D1 (de) | 2003-05-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |