ATE236152T1 - Benzothiophenverbindungen, zwischenprodukte, verfahren und verwendungsmethode - Google Patents

Benzothiophenverbindungen, zwischenprodukte, verfahren und verwendungsmethode

Info

Publication number
ATE236152T1
ATE236152T1 AT97304458T AT97304458T ATE236152T1 AT E236152 T1 ATE236152 T1 AT E236152T1 AT 97304458 T AT97304458 T AT 97304458T AT 97304458 T AT97304458 T AT 97304458T AT E236152 T1 ATE236152 T1 AT E236152T1
Authority
AT
Austria
Prior art keywords
alkyl
optionally substituted
substituted phenyl
benzothiophene compounds
intermediate products
Prior art date
Application number
AT97304458T
Other languages
English (en)
Inventor
George Joseph Cullinan
Kennan Joseph Fahey
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE236152T1 publication Critical patent/ATE236152T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97304458T 1996-07-02 1997-06-25 Benzothiophenverbindungen, zwischenprodukte, verfahren und verwendungsmethode ATE236152T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2102696P 1996-07-02 1996-07-02

Publications (1)

Publication Number Publication Date
ATE236152T1 true ATE236152T1 (de) 2003-04-15

Family

ID=21801903

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97304458T ATE236152T1 (de) 1996-07-02 1997-06-25 Benzothiophenverbindungen, zwischenprodukte, verfahren und verwendungsmethode

Country Status (7)

Country Link
US (1) US6432983B1 (de)
EP (1) EP0816360B1 (de)
JP (1) JPH1067776A (de)
AT (1) ATE236152T1 (de)
CA (1) CA2206752A1 (de)
DE (1) DE69720326T2 (de)
ES (1) ES2196262T3 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9308264B2 (en) 2000-11-08 2016-04-12 Fxs Ventures, Llc Ophthalmic contact lens solutions containing forms of vitamin B
DE60202954T2 (de) 2001-05-22 2006-01-05 Eli Lilly And Co., Indianapolis Tetrahydrochinolin-derivate zur behandlung von krankheiten ausgelöst durch zu hohem oder zu niedrigem oestrogenspiegel
DE60210283T2 (de) 2001-05-22 2006-11-09 Eli Lilly And Co., Indianapolis 2-substituierte 1,2,3,4-tetrahydrochinoline und derivate davon, zusammensetzungen und verfahren
US9962362B2 (en) 2012-03-29 2018-05-08 Children's Hospital Medical Center Use of small molecule inhibitors targeting EYA tyrosine phosphatase
US9725430B2 (en) * 2013-01-16 2017-08-08 Children's Hospital Medical Center Use of small molecule inhibitors targeting EYA tyrosine phosphatase

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1138163A (en) 1965-05-21 1968-12-27 Bristol Myers Co Benzothiophene derivatives having anti-fertility properties
US3394125A (en) 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
US4230862A (en) 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4133814A (en) 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
US4358593A (en) 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
GB2097788B (en) * 1981-04-03 1985-04-24 Lilly Co Eli Benzothiophene compounds and process for preparing them
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
WO1989002893A1 (en) 1987-09-30 1989-04-06 The University Of Tennessee Research Corporation Certain 3-substituted 2-alkyl benzothiophene derivatives
US5395842A (en) 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
TW366342B (en) * 1992-07-28 1999-08-11 Lilly Co Eli The use of 2-phenyl-3-aroylbenzothiophenes in inhibiting bone loss
TW383306B (en) * 1992-12-22 2000-03-01 Lilly Co Eli New use of 2-phenyl-3-aroylbenzothiophenes in lowering serum cholesterol
US5482949A (en) * 1993-03-19 1996-01-09 Eli Lilly And Company Sulfonate derivatives of 3-aroylbenzo[b]thiophenes
US6756388B1 (en) 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5457113A (en) * 1993-10-15 1995-10-10 Eli Lilly And Company Methods for inhibiting vascular smooth muscle cell proliferation and restinosis
CA2176130A1 (en) * 1993-12-21 1995-06-29 Thomas Alan Crowell Non-peptide tachykinin receptor antagonists
WO1995017095A1 (en) * 1993-12-21 1995-06-29 Eli Lilly And Company Methods for the treatment or prevention of conditions associated with amyloidogenic reptides
US6399634B1 (en) * 1994-09-20 2002-06-04 Eli Lilly And Company Benzothiophene compounds, compositions, and methods
IL115582A0 (en) * 1994-10-14 1996-01-19 Lilly Co Eli Methods for treating resistant tumors
EP0707852A3 (de) * 1994-10-20 1998-08-19 Eli Lilly And Company Bizyklische Bradykinin-Rezeptor-Antagoniste
US5663192A (en) * 1994-10-20 1997-09-02 Eli Lilly And Company Heterocyclic neuropeptide Y receptor antagonists
IL115613A0 (en) * 1994-10-20 1996-01-19 Lilly Co Eli Bicyclic neuropeptide y receptor antagonists
US5552412A (en) * 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis

Also Published As

Publication number Publication date
JPH1067776A (ja) 1998-03-10
US6432983B1 (en) 2002-08-13
EP0816360A1 (de) 1998-01-07
DE69720326D1 (de) 2003-05-08
CA2206752A1 (en) 1998-01-02
ES2196262T3 (es) 2003-12-16
DE69720326T2 (de) 2003-11-27
EP0816360B1 (de) 2003-04-02

Similar Documents

Publication Publication Date Title
NO971278L (no) Naftylforbindelser, mellomprodukter, fremgangsmåter, sammensetninger og metoder
DE69705480D1 (de) Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung
PT85607A (en) Process for preparing dihydropyride anti allergic and anti-inflammatory agents
DE69010285T2 (de) Als Spasmolytica geeignete Dibenzothiazepin-Derivate.
ATE236152T1 (de) Benzothiophenverbindungen, zwischenprodukte, verfahren und verwendungsmethode
ATE207473T1 (de) Dihydronaphthalen- und naphthalenderivate, zwischenverbindungen, zusammensetzungen und deren herstellungsverfahren
ES2043834T3 (es) Un procedimiento para preparar nuevos derivados de androsta-1,4-dien-3-ona sustituida en la posicion 17.
ATE255574T1 (de) Benzo(b)thiophenverbindungen,zwischenprodukte, verfahren,zusammensetzungen und methode
NZ334184A (en) Naphthyl compounds, intermediates, compositions for the prevention of bone loss or bone resorption and lower cholesterol
IE901314L (en) 2- substituted-n,n'-di(trimethoxybenzoyl)piperazines
DK0556813T3 (da) Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler
ATE215536T1 (de) Benzofluorenverbindungen, zwischenverbindungen, zusammensetzungen und verfahren
EP0806412A4 (de)
GB9407637D0 (en) Serotoninergic abeo-ergoline derivatives
HUP0303349A2 (hu) Szubsztituált bifenilszármazékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyszerészeti készítmények
ATE148099T1 (de) Tri(c1-c6 alkoxy)benzolderivat
DK163922C (da) 2,3-dihydro-3-phenyl-2-benzofuranonderivater, fremgangsmaader til deres fremstilling og farmaceutiske midler indeholdende dem
TW254937B (en) Benzocycloheptene derivative and process for preparation thereof
MX9703112A (es) Nitro-benzamidas utiles como agentes antiarritmicos.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties