ATE231142T1 - Cyclopropachromencarbonsäure derivate - Google Patents
Cyclopropachromencarbonsäure derivateInfo
- Publication number
- ATE231142T1 ATE231142T1 AT95934860T AT95934860T ATE231142T1 AT E231142 T1 ATE231142 T1 AT E231142T1 AT 95934860 T AT95934860 T AT 95934860T AT 95934860 T AT95934860 T AT 95934860T AT E231142 T1 ATE231142 T1 AT E231142T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- carbon atoms
- substituted
- hydrogen atom
- atom
- Prior art date
Links
- VUAKCICNISMYQX-UHFFFAOYSA-N cyclopropa[h]chromene-6-carboxylic acid Chemical class C1=CC2=CC2=C2OC(C(=O)O)=CC=C21 VUAKCICNISMYQX-UHFFFAOYSA-N 0.000 title abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 hydroxyimino group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP25646894 | 1994-10-21 | ||
| JP22536595A JP3993651B2 (ja) | 1994-10-21 | 1995-09-01 | シクロプロパクロメンカルボン酸誘導体 |
| PCT/JP1995/002163 WO1996012715A1 (en) | 1994-10-21 | 1995-10-20 | Cyclopropachromenecarboxylate derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE231142T1 true ATE231142T1 (de) | 2003-02-15 |
Family
ID=26526593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95934860T ATE231142T1 (de) | 1994-10-21 | 1995-10-20 | Cyclopropachromencarbonsäure derivate |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5843988A (de) |
| EP (1) | EP0787723B1 (de) |
| JP (1) | JP3993651B2 (de) |
| AT (1) | ATE231142T1 (de) |
| DE (1) | DE69529418T2 (de) |
| ES (1) | ES2191063T3 (de) |
| WO (1) | WO1996012715A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19801646A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte alpha,beta-annellierte Butyrolactone |
| DE19801647A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte beta,gamma-annellierte Lactone |
| DE19801636A1 (de) | 1998-01-17 | 1999-07-22 | Bayer Ag | Substituierte bicyclische Lactone |
| AU2642699A (en) * | 1998-03-03 | 1999-09-20 | Yamanouchi Pharmaceutical Co., Ltd. | Remedies for brain infarction |
| GB9823845D0 (en) * | 1998-11-02 | 1998-12-23 | Lilly Co Eli | Pharmaceutical compounds |
| AU2241400A (en) | 1999-04-06 | 2000-10-12 | Yamanouchi Pharmaceutical Co., Ltd. | Novel thiazolobenzoimidazole derivative |
| GB0007193D0 (en) * | 2000-03-25 | 2000-05-17 | Univ Manchester | Treatment of movrmrnt disorders |
| US6660858B2 (en) * | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
| US20060166972A1 (en) * | 2003-07-11 | 2006-07-27 | Conn P J | Treatment of movement disorders with a metabotropic glutamate 4 receptor positive allosteric modulator |
| BRPI0513672A (pt) | 2004-07-30 | 2008-05-13 | Torrent Pharmaceuticals Limita | processo aperfeiçoado para a preparação de 2h-1-benzopiran-2metanol, (alfa). (alfa)' [iminobis (metileno)] bis [6-fluoro-3, 4-dihidro, [2r* [r* [r* (s*)]]]], composição farmacêutica, forma t1 amorfa, e processo para a preparação da forma t1 de hidrocloreto de nebivolol |
| DE102005011534A1 (de) * | 2005-03-10 | 2006-09-21 | Merck Patent Gmbh | Chromen-4-on-Derivate |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| EP2314289A1 (de) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
| DE102005062990A1 (de) * | 2005-12-28 | 2007-07-05 | Grünenthal GmbH | Substituierte Thiazole und ihre Verwendung zur Herstellung von Arzneimitteln |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2651862A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| WO2008030651A1 (en) * | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| DK2493871T3 (da) * | 2009-10-30 | 2014-11-10 | Prestwick Chemical Sas | Nye oximderivater samt deres anvendelse som allosteriske modulatorer af metabotropiske glutamatreceptorer |
| LT3186257T (lt) | 2014-08-27 | 2019-04-25 | Prexton Therapeutics Sa | Nauji chromono oksimo dariniai ir jų panaudojimas kaip metabotropinių gliutamato receptorių alosterinių moduliatorių |
| CN108349993A (zh) | 2015-08-27 | 2018-07-31 | 普雷克斯顿医疗股份公司 | 用于左旋多巴诱导的运动障碍疗法的脑-穿透剂色酮肟衍生物 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0723367B2 (ja) * | 1986-02-27 | 1995-03-15 | サントリー株式会社 | オキサビシクロヘプタン誘導体 |
| CA2037187A1 (en) * | 1990-06-06 | 1991-12-07 | Toshio Tatsuoka | Cyclopropachromen derivatives |
| JP3089040B2 (ja) * | 1990-06-06 | 2000-09-18 | サントリー株式会社 | 脳神経変性性疾患治療剤 |
| DE4018468A1 (de) * | 1990-06-08 | 1991-12-12 | Ultrakust Electronic Gmbh | Verfahren und vorrichtung zur entnahme einer repraesentativen milchprobe |
-
1995
- 1995-09-01 JP JP22536595A patent/JP3993651B2/ja not_active Expired - Fee Related
- 1995-10-20 DE DE69529418T patent/DE69529418T2/de not_active Expired - Lifetime
- 1995-10-20 ES ES95934860T patent/ES2191063T3/es not_active Expired - Lifetime
- 1995-10-20 AT AT95934860T patent/ATE231142T1/de not_active IP Right Cessation
- 1995-10-20 US US08/817,389 patent/US5843988A/en not_active Expired - Lifetime
- 1995-10-20 EP EP95934860A patent/EP0787723B1/de not_active Expired - Lifetime
- 1995-10-20 WO PCT/JP1995/002163 patent/WO1996012715A1/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP3993651B2 (ja) | 2007-10-17 |
| ES2191063T3 (es) | 2003-09-01 |
| EP0787723A4 (de) | 1998-02-04 |
| EP0787723B1 (de) | 2003-01-15 |
| DE69529418T2 (de) | 2003-08-14 |
| EP0787723A1 (de) | 1997-08-06 |
| JPH08169884A (ja) | 1996-07-02 |
| WO1996012715A1 (en) | 1996-05-02 |
| DE69529418D1 (de) | 2003-02-20 |
| US5843988A (en) | 1998-12-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE231142T1 (de) | Cyclopropachromencarbonsäure derivate | |
| ATE131479T1 (de) | 1,3-dihydro-2h-imidano 4,5-b-quinolin-2-ein derivate als phosphodiestenase hemmer | |
| MY131297A (en) | Herbicides | |
| DK0590919T3 (da) | Terapeutiske midler mod Parkinsons sygdom | |
| DK0870768T3 (da) | Azaindol-ethylaminderivater som nikotinacetylcholinreceptor-bindingsmidler | |
| NZ509045A (en) | Intermediates in the formation of antivirally active heterocyclic azahexane derivatives | |
| MY110447A (en) | New herbicides | |
| FI942635A0 (fi) | Piperatsiinijohdannaiset 5HT1A-antagonisteina | |
| DK0572093T3 (da) | Herbicide 2,6-substituerede pyridiner | |
| ATE144511T1 (de) | Tetrahydrobenzimidazol-derivate | |
| EP1110961A4 (de) | Sauerstoffhaltige heterocyclische verbindungen | |
| EP1004573A4 (de) | Aryloxyanilin-derivate | |
| MX9101232A (es) | Derivados de benceno,piridina y pirimidina | |
| DE69733308D1 (de) | Aktivsauerstoffaufnehmer enthaltende pterinderivate | |
| ATE143661T1 (de) | Imidazonaphthyridinderivate | |
| NZ221699A (en) | Pyridazinone derivatives; pharmaceutical compositions and intermediates | |
| DE60016384D1 (de) | Chondrogonese promotoren und indolin-2-on derivate | |
| ATE185806T1 (de) | Oxopyridylchinoxalin derivate | |
| DK0806413T3 (da) | 2-substituerede viatmin D3-derivater | |
| EP0878196A4 (de) | Inhibitoren der kainsäure-neurotoxizität sowie pyridothiazinderivate | |
| ATE504572T1 (de) | Derivate von aromatische heterocyclen enthaltende integraseinhibitoren | |
| EP0719773A4 (de) | Imidazolidinon-derivate, deren säure-additionssalze und her mittel gegen senile demenz | |
| MX9202178A (es) | Nuevos derivados de 2-piperacinil bencimidazol. | |
| ATE151750T1 (de) | 3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind | |
| ATE105565T1 (de) | Pradimicinderivate. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |