ATE228120T1 - Biphenylsulfonylarylcarbonsäuren verwendbar zur behandlung von insulin resistenz und hyperglycemia - Google Patents

Biphenylsulfonylarylcarbonsäuren verwendbar zur behandlung von insulin resistenz und hyperglycemia

Info

Publication number
ATE228120T1
ATE228120T1 AT99921830T AT99921830T ATE228120T1 AT E228120 T1 ATE228120 T1 AT E228120T1 AT 99921830 T AT99921830 T AT 99921830T AT 99921830 T AT99921830 T AT 99921830T AT E228120 T1 ATE228120 T1 AT E228120T1
Authority
AT
Austria
Prior art keywords
carbon atoms
alkyl
nitrogen
trifluoromethyl
alkoxy
Prior art date
Application number
AT99921830T
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Folake Oluwemimo Adebayo
Paul Jeffrey Dollings
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE228120T1 publication Critical patent/ATE228120T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT99921830T 1998-05-12 1999-05-10 Biphenylsulfonylarylcarbonsäuren verwendbar zur behandlung von insulin resistenz und hyperglycemia ATE228120T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7659798A 1998-05-12 1998-05-12
PCT/US1999/010213 WO1999058520A1 (en) 1998-05-12 1999-05-10 Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia

Publications (1)

Publication Number Publication Date
ATE228120T1 true ATE228120T1 (de) 2002-12-15

Family

ID=22133045

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99921830T ATE228120T1 (de) 1998-05-12 1999-05-10 Biphenylsulfonylarylcarbonsäuren verwendbar zur behandlung von insulin resistenz und hyperglycemia

Country Status (8)

Country Link
EP (1) EP1077966B1 (de)
JP (1) JP2002514637A (de)
CN (1) CN1308620A (de)
AT (1) ATE228120T1 (de)
AU (1) AU3894099A (de)
CA (1) CA2330599A1 (de)
DE (1) DE69904041D1 (de)
WO (1) WO1999058520A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911468B2 (en) 2000-05-22 2005-06-28 Takeda Chemical Industries, Ltd. Tyrosine phosphatase inhibitors
WO2003048140A1 (fr) 2001-12-03 2003-06-12 Japan Tobacco Inc. Compose azole et utilisation medicinale de celui-ci
EP1620420A2 (de) 2003-04-30 2006-02-01 The Institutes for Pharmaceutical Discovery, LLC Substituierte carbonsäuren
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
CN107033122B (zh) * 2017-05-19 2019-06-14 南方医科大学 一种n-芳基-2-噻吩酰胺类衍生物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58183676A (ja) * 1982-04-19 1983-10-26 Takeda Chem Ind Ltd オキサゾ−ル誘導体
DE3700732A1 (de) * 1987-01-13 1988-07-21 Boehringer Mannheim Gmbh Neue carbonsaeurederivate, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
AU3719997A (en) * 1996-07-01 1998-01-21 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds

Also Published As

Publication number Publication date
AU3894099A (en) 1999-11-29
DE69904041D1 (de) 2003-01-02
WO1999058520A1 (en) 1999-11-18
JP2002514637A (ja) 2002-05-21
EP1077966B1 (de) 2002-11-20
CN1308620A (zh) 2001-08-15
EP1077966A1 (de) 2001-02-28
CA2330599A1 (en) 1999-11-18

Similar Documents

Publication Publication Date Title
ATE229015T1 (de) Zur behandlung von insulin-resistenz und hyperglycemie geeignete biphenyl-oxo-essigsäuren
ECSP941146A (es) Derivados de benzofurano
ATE334973T1 (de) Chinazolinverbindungen
DE69738740D1 (de) Verwendung von Oestrogen Antagonisten und Oestrogen Agonisten zur Behandlung von pathologischen Zuständen
DE69705480D1 (de) Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung
EA200600358A1 (ru) Фенил- или пиридиламидные соединения в качестве антагонистов простагландина е2
DE69736642D1 (de) Heterocyclische Verbindungen, ihre Herstellung und Verwendung
PL346345A1 (en) Heterocyclic compounds and methods to treat cardiac failure and other disorders
EE04310B1 (et) Bensimidasooli ühendid, neid ühendeid sisaldavad farmatseutilised kompositsioonid ja nende kasutamine
DE69332792D1 (de) 4,1-Benzoxazepinderivate als Squalen-Synthetase Inhibitoren und ihre Verwendung zur Behandlung von Hypercholesterämie und als Fungizide
DE68906183D1 (de) 2'-desoxy-5-fluoruridinderivate.
PT1280809E (pt) Derivados antitumorais de ecteinascidina
ATE378046T1 (de) Carbamatverbindungen zur vorbeugung oder behandlung bipolarer erkrankungen
ATE228120T1 (de) Biphenylsulfonylarylcarbonsäuren verwendbar zur behandlung von insulin resistenz und hyperglycemia
ATE324107T1 (de) Carbamat-verbindungen zur prävention oder behandlung von angstzuständen
KR880000381A (ko) 치환 3-아미노-2-벤조일시클로헥스-2-에논과 이를 이용한 제초제 조성물 및 식물체 억제방법
ATE268328T1 (de) Neue diazol-derivate und ihre verwendung als serotonergische wirkstoffe
DE69228877D1 (de) Benzoaxole,benzothiazol und benzimidazol derivate als fungizide
DK59693A (da) Fremgangsmaade til fremstilling af en 16,17-acetalsubstitueret androstan-17beta-(2-oxoethylenoxy)-forbindelse
ATE71370T1 (de) 2-amino-5-hydroxy-4-pyrimidone.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties