ATE227294T1 - Selektive inhibitoren für den n-terminalen site der ace - Google Patents

Selektive inhibitoren für den n-terminalen site der ace

Info

Publication number
ATE227294T1
ATE227294T1 AT99926580T AT99926580T ATE227294T1 AT E227294 T1 ATE227294 T1 AT E227294T1 AT 99926580 T AT99926580 T AT 99926580T AT 99926580 T AT99926580 T AT 99926580T AT E227294 T1 ATE227294 T1 AT E227294T1
Authority
AT
Austria
Prior art keywords
selective inhibitors
terminal site
ace
po2ch2
amino acid
Prior art date
Application number
AT99926580T
Other languages
English (en)
Inventor
Vincent Dive
Joel Cotton
Philippe Cuniasse
Athanasios Yiotakis
Pierre Corvol
Annie Michaud
Marie-Therese Chauvet
Joel Menard
Eric Ezan
Original Assignee
Commissariat Energie Atomique
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Inst Nat Sante Rech Med filed Critical Commissariat Energie Atomique
Application granted granted Critical
Publication of ATE227294T1 publication Critical patent/ATE227294T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/30Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301Acyclic saturated acids which can have further substituents on alkyl
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT99926580T 1998-07-02 1999-07-01 Selektive inhibitoren für den n-terminalen site der ace ATE227294T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9808464A FR2781230B1 (fr) 1998-07-02 1998-07-02 Derives de peptides utilisables comme inhibiteur selectif du site n-terminal de l'enzyme de conversion de l'angiotensine humaine
PCT/FR1999/001581 WO2000001706A1 (fr) 1998-07-02 1999-07-01 Inhibiteurs selectifs de site n-terminal de l'eca

Publications (1)

Publication Number Publication Date
ATE227294T1 true ATE227294T1 (de) 2002-11-15

Family

ID=9528171

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99926580T ATE227294T1 (de) 1998-07-02 1999-07-01 Selektive inhibitoren für den n-terminalen site der ace

Country Status (11)

Country Link
US (1) US6482797B1 (de)
EP (1) EP1091966B1 (de)
JP (1) JP2002519430A (de)
AT (1) ATE227294T1 (de)
CA (1) CA2335918A1 (de)
DE (1) DE69903816T2 (de)
DK (1) DK1091966T3 (de)
ES (1) ES2186366T3 (de)
FR (1) FR2781230B1 (de)
PT (1) PT1091966E (de)
WO (1) WO2000001706A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2834989B1 (fr) 2002-01-18 2005-05-20 Commissariat Energie Atomique Derives de pseudo-peptides phosphiniques inhibant selectivement le site actif c-terminal de l'enzyme de conversion de l'angiotensine i(ace)
US20110104175A1 (en) * 2008-06-03 2011-05-05 Cedars-Sinai Medical Center Methods of treatment for pulmonary fibrosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0209848A3 (de) * 1985-07-24 1988-07-27 Merck & Co. Inc. Enzyminhibitoren
FR2676059B1 (fr) * 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
FR2730235A1 (fr) * 1995-02-06 1996-08-09 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
JP2002519430A (ja) 2002-07-02
DE69903816D1 (de) 2002-12-12
WO2000001706A1 (fr) 2000-01-13
DE69903816T2 (de) 2003-09-11
FR2781230A1 (fr) 2000-01-21
CA2335918A1 (fr) 2000-01-13
FR2781230B1 (fr) 2000-09-01
EP1091966B1 (de) 2002-11-06
DK1091966T3 (da) 2003-03-03
ES2186366T3 (es) 2003-05-01
US6482797B1 (en) 2002-11-19
EP1091966A1 (de) 2001-04-18
PT1091966E (pt) 2003-03-31

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